Effect of Propranolol on Hepatic Blood Flow in Normal and Portal Hypertensive Rats

Hillon, Patrick; Blanchet, L.; Lebrec, Didier

doi:10.1042/cs0630029

Cited by 44 publications

(17 citation statements)

References 8 publications

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“…This indicates that some organs of this territory have relative protection from the effects of propranolol. Similar hemodynamic effects were observed in normal conscious rabbits (24) and dogs ( 2 5 ) receiving propranolol, whereas in anesthetized portal hypertensive rats, the variations seemed to be of the same magnitude in all organs (16)(17)(18). In patients with portal hypertension, such hemodynamic effects of propranolol on splanchnic blood flow cannot be measured since no method is available.…”

Section: Discussionsupporting

confidence: 77%

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Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in a wake portal hypertensive rats

et al. 1989

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The effects of increasing doses of propranolol were studied in awake portal hypertensive rats in order to elucidate the relative effects of the beta-blocker on systemic and splanchnic circulation. Hemodynamic responses to 0.1, 0.2 and 0.4 mg per min infusions of propranolol were compared with placebo in awake rats with portal hypertension due to portal vein stenosis. Heart rate significantly and progressively decreased from 356 +/- 13 to 293 +/- 10 beats per min (mean +/- S.E.). Cardiac output significantly decreased from 54 +/- 3 to 42 +/- 3 ml per min per 100 gm body weight at the highest dose. Significant decrease in portal tributary blood flow from 27 +/- 1 to 18 +/- 1 ml per min, at 0.4 mg per min dose, was due not only to the decrease in cardiac output but also to a significant increase in portal tributary vascular resistance from 269 +/- 17 to 368 +/- 31 dyne per sec per cm5 x 10(3). However, portal pressure showed only an insignificant decrease from 14.9 +/- 1.1 to 14.1 +/- 1.4 mmHg. The reduction in portal pressure being minimal, in spite of a significant decrease in portal tributary blood flow, is explained by an increase in combined hepatic and collateral resistance from 44 +/- 2 to 66 +/- 4 dyne per sec per cm5 x 10(3), p less than 0.05, at 0.4 mg per min dose. We conclude that the systemic and splanchnic effects of propranolol show discrepancy at two levels.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 77%

“…These systemic hemodynamic responses are well established and were previously found in anesthetized rats with portal hypertension receiving propranolol (16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 64%

Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in a wake portal hypertensive rats

et al. 1989

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“…Since liver blood flow is the sum of portal venous and hepatic artery blood flows, the discrepancy between a marked reduction of azygos venous blood flow and a mild decrease of liver blood flow may be due to a relative increase of hepatic artery blood flow after @-blockade. This phenomenon has been observed in rats with experimental portal hypertension after acute administration of propranolol (17).…”

Section: Discussionmentioning

confidence: 92%

Effects of Propranolol on Azygos Venous Blood Flow and Hepatic and Systemic Hemodynamics in Cirrhosis

et al. 1984

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The effects of propranolol on blood flow through gastroesophageal collaterals and on systemic and hepatic hemodynamics were investigated in 23 cirrhotic patients with portal hypertension. Gastroesophageal collateral blood flow was evaluated by the measurement of azygos venous blood flow by continuous thermal dilution. Azygos venous blood flow was markedly increased in these patients (544 +/- 48 ml per min, as compared with 132 +/- 18 ml per min in subjects without portal hypertension (p less than 0.001). Propranolol at doses achieving effective beta-blockage (83 +/- 5 mg) (mean +/- S.E.M.) markedly reduced azygos venous blood flow (to 354 +/- 34 ml per min, p less than 0.001). Reduction of azygos venous blood flow (-34.2 +/- 3.6%) was significantly greater (p less than 0.01) than reductions in cardiac output (-22.6 +/- 1.9%), hepatic venous pressure gradient (-11.5 +/- 2.4%) and hepatic blood flow (-13.4 +/- 7.4%). The hemodynamic effects of propranolol were not related to plasma norepinephrine levels. Reduction of gastroesophageal collateral blood flow may be the mechanism by which oral propranolol therapy reduces the risk of repeated episodes of variceal bleeding in cirrhotic patients with portal hypertension.

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“…Several pharmacologic agents, including P-blockers, appear to reduce portal pressure by reducing portal blood flow (16)(17)(18)(19).…”

mentioning

confidence: 99%

Increased Portal Venous Resistance Hinders Portal Pressure Reduction During the Administration of β–Adrenergic Blocking Agents in A Portal Hypertensive Model

1985

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We have recently shown that maintenance of portal hypertension in rats is highly dependent on high portal blood flow. This study attempts to determine whether portal hypertension, induced in the rat by partial constriction of the portal vein, can be reduced by lowering portal blood flow with a beta blocking agent. Portal hypertensive rats treated with propranolol had a reduction in portal blood flow to 0.89 +/- 0.13 ml X min-1 X gm-1 accompanied by reduction in portal pressure to 12.6 +/- 1.00 mm Hg, disproportionately small because of a rise in portal-collateral vascular resistance to 12.52 +/- 1.63 dyne X sec X cm-5 X gm X 10(5) accompanying the portal blood flow reduction. Similarly, portal hypertensive rats receiving beta-blockade with H35-25, an experimental beta-blocker, demonstrated a 49% reduction in portal blood flow accompanied by only a 14% reduction in portal pressure, also disproportionately low because of a complicating 77% rise in portal-collateral vascular resistance. Normal rats were then given saline infusion to achieve similar blood flow elevations to that of portal hypertensive animals.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effect of Propranolol on Hepatic Blood Flow in Normal and Portal Hypertensive Rats

Cited by 44 publications

References 8 publications

Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in a wake portal hypertensive rats

Discrepancy between portal pressure and systemic hemodynamic changes after incremental doses of propranolol in a wake portal hypertensive rats

Effects of Propranolol on Azygos Venous Blood Flow and Hepatic and Systemic Hemodynamics in Cirrhosis

Increased Portal Venous Resistance Hinders Portal Pressure Reduction During the Administration of β–Adrenergic Blocking Agents in A Portal Hypertensive Model

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