Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats.

Sugimoto, Yukiko; Tarumi, Tadatsugu; Isayama, Shinji; Kawai, Nobuyuki; Sugimoto, Hiroyuki; Yamada, Hideo; Kamei, Chiaki

doi:10.1248/bpb.22.1237

Cited by 17 publications

(9 citation statements)

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“…These results agreed with Eraslan et al [42]. Results of liver enzymes activities support that propolis is able to induce hepatoprotective effects which are similar to those of the previous work on propolis that act as hepatoprotective against d-galactosamine, and paracetamol induced liver damage in rats and mice, respectively [44, 45]. The present results were confirmed by absence of histopathological changes in livers of groups (2) and (4) in comparison with liver of control group.…”

Section: Discussionsupporting

confidence: 91%

Protective Effect of Egyptian Propolis against Rabbit Pasteurellosis

Nassar

Mohamed

Soufy

et al. 2013

BioMed Research International

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The present study was conducted to study the protective effect of ethanolic extract of propolis given subcutaneously (S/C) either alone or in combination with inactivated formalized Pasteurella multocida (P. multocida) vaccine in rabbits challenged with virulent P. multocida strain. Twenty-eight New-Zealand rabbits, 6–8 weeks old and not vaccinated against pasteurellosis, were randomly divided into four equal groups. Group (1) was kept as nonvaccinated control. Group (2) was injected S/C with propolis. Group (3) was vaccinated (S/C) with P. multocida vaccine only. Group (4) was injected with vaccine mixed with propolis as adjuvant. Groups (2, 3, and 4) received the same doses of propolis and vaccine after 4 weeks as a booster dose. The experiment continued for six weeks during which clinical signs, body weight, and mortality rate were recorded. Blood samples were collected every 2 weeks of treatment for evaluating the erythrogram and biochemical parameters. At the end of six weeks, all groups were subjected to challenge with a virulent strain of P. multocida. Two weeks later, tissue specimens were collected from different organs for histopathological investigation. Results showed that before challenge all rabbits of different groups were apparently healthy and had good appetite. After challenge, control group (1) showed acute form of the disease, 100% mortality rate, and severe histopathological changes. Rabbits of groups (2 and 3) showed less severe clinical signs, mortality rate, and histopathological changes than control. Rabbits of group (4) were apparently healthy with normal histological picture. In conclusion, an ethanolic extract of propolis injected alone or combined with formalized inactivated P. multocida vaccine improved general health conditions, liver and kidney functions in addition to reduction of the severity of adverse clinical signs, mortality rates, and histopathological changes associated with challenge of rabbits with P. multocida strain.

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Section: Discussionsupporting

confidence: 91%

Protective Effect of Egyptian Propolis against Rabbit Pasteurellosis

Nassar

Mohamed

Soufy

et al. 2013

BioMed Research International

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“…Similarly, Cuban propolis was also reported to have a hepatoprotective effect against D-GalN-induced hepatitis in rats . Recently, Sugimoto et al (1999) studied the hepatoprotective effect of Brazilian propolis on D-GalN-induced hepatic injury in rats. When the 95% ethanol extract was administered p.o.…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Recent progress in pharmacological research of propolis

Banskota

Tezuka

Kadota

2001

Phytotherapy Research

736

553

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Propolis is a resinous hive product collected by honeybees from various plant sources. It is a popular folk medicine possessing a broad spectrum of biological activities. It has also been used as a health drink in various Asian, European and American countries. Several groups of researchers have focused their attention on the biological activity of propolis and its active principles. Many scientific articles are published every year in different international journals related to the pharmacological properties of propolis. This review article compiles recent findings (since 1995) on the pharmacological properties of propolis focusing on its antihepatotoxic, antitumour, antioxidative, antimicrobial and antiinflammatory properties. The possible mechanism of action of propolis as well as the active compounds are discussed.

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“…In those studies the dose ranged between 30 and 200 mg/kg/day [9,10] . In this study, we gave 100 mg/kg/day propolis to each rat.…”

Section: Preparation Of Propolis Extractmentioning

confidence: 99%

Effect of Propolis on Oxidative Stress and Histomorphology of Liver Tissue in Experimental Obstructive Jaundice

et al. 2008

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Background: Propolis is a natural product collected by honey bees from various plant sources. We aimed to determine the possible effects of propolis on oxidative stress and hepatocyte apoptosis in experimental obstructive jaundice. Methods:Thirty rats were divided into three groups: group I, sham-operated; group II, ligation and division of the common bile duct (BDL); group III, BDL followed by oral supplementation of propolis in a daily dose of 100 mg/kg. Liver samples were examined under the light microscope and transmission electron microscope. Hepatocyte apoptosis was quantitated using the transferase-mediated uridine nick end labeling (TUNEL) assay. Plasma and liver malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities were measured. Results: The plasma and liver levels of MDA were significantly lower in the propolis group than in the BDL group (p < 0.05 and 0.014, respectively). Although liver GSH-Px activities were significantly higher in the propolis group than in the BDL group (p < 0.001), there was no significant difference between the plasma GSH-Px activities of these groups (p > 0.05). In the propolis group, the enlargement of hepatocytes, dilatation of canaliculi and the edema regressed. The regenerating and normal hepatocytes were demonstrated. In the TUNEL assay, propolis administration reduced hepatocyte apoptosis. Conclusion: Propolis showed a significant hepatoprotective effect in this experimental obstructive jaundice model.

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Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats.

Cited by 17 publications

References 0 publications

Protective Effect of Egyptian Propolis against Rabbit Pasteurellosis

Protective Effect of Egyptian Propolis against Rabbit Pasteurellosis

Recent progress in pharmacological research of propolis

Effect of Propolis on Oxidative Stress and Histomorphology of Liver Tissue in Experimental Obstructive Jaundice

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