Effect of Propofol on Arachidonate Cascade by Vasopressin in Aortic Smooth Muscle Cells

Tanabe, Kumiko; Kozawa, Osamu; Matsuno, Hiroyuki; Niwa, Masayuki; Dohi, Shuji

doi:10.1097/00000542-199901000-00028

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…anaesthetic drugs on coronary artery tone are virtually completely lacking. A number of authors have investigated the influence of propofol and thiopental on isolated segments of cerebral, mesenteric, femoral and renal arteries in different animal preparations [7,13,24–42]. Dilating effects were demonstrated for both drugs in most of these studies.…”

Section: Discussionmentioning

confidence: 99%

Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

et al. 2000

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The effects of propofol and thiopental on three vasoconstrictors, acetylcholine, histamine, and serotonin were studied in isolated porcine and human coronary artery rings. Propofol and thiopental attenuated the contractile response to all mediators in a dose-dependent manner. This dilating effect was fairly weak using low concentrations (propofol 1 microg mL-1 and 10 microg mL-1, thiopental 5 microg mL-1 and 10 microg mL-1). In the presence of high concentrations (propofol 100 microg mL-1, thiopental 50 microg mL-1) marked relaxation was observed (propofol -32% up to -49%, P < 0,05; thiopental -23% up to -67%, P < 0.05). These dilating effects were seen both in intact and denuded rings, the differences were not significant. Human coronary artery segments were relaxed by thiopental (-22% to -76%) and propofol (-11% to -67%) to a similar extent. Our data indicate that propofol and thiopental relax isolated coronary segments in a dose-dependent manner, and that there is no evidence that these effects are dependent of endothelial factors.

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Section: Discussionmentioning

confidence: 99%

Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

et al. 2000

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“…Previous Observations. 239, 240 In support of this finding, in VSMCs of isolated mesenteric arteries, propofol (Ն 30 M) inhibited norepinephrine-induced Ca 2ϩ release from the SR; however, it did not affect caffeineinduced Ca 2ϩ release even at 100 M. 145 Similarly, in VSMCs of isolated mesenteric arteries, midazolam (Ն 1 M) inhibited norepinephrine-induced, but not caffeineinduced, Ca 2ϩ release from the SR. 170 Interpretations. 139,140 However, ketamine (1 mM) did not affect the IICR in membrane-permeabilized VSMCs.…”

Section: Anesthetic Effects On the Intracellular Calcium Stores (Sr)mentioning

confidence: 93%

General Anesthetics and Vascular Smooth Muscle

Akata

2007

Anesthesiology

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General anesthetics threaten cardiovascular stability by causing changes in cardiac function, vascular reactivity, and cardiovascular reflexes and significantly alter distribution of cardiac output to various organs. Their overall impact is often systemic hypotension, which is attributable to myocardial depression, peripheral vasodilation, and attenuated sympathetic nervous system activity. However, one could be more causative than the others, depending on anesthetic agents and cardiovascular factors inherent in patients (e.g., coexisting heart disease). It is generally believed that most general anesthetics attenuate sympathetic nervous system outflow from the central nervous system, thereby decreasing vascular resistance in peripheral circulations. Indeed, in previous in vivo studies, during administration of various general anesthetics, vascular resistance was decreased in most peripheral circulations; however, it was unaffected or increased in some peripheral circulations. General anesthetics may act directly on vascular smooth muscle and/or endothelial cells in various vascular beds, influencing total peripheral and/or regional vascular resistance, and hence organ blood flow. This article reviews previously reported direct (i.e., nonneural) vascular actions of general anesthetics and discusses their underlying mechanisms, their in vivo relevance, and the future of research for general anesthetic vascular pharmacology.

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“…The results of this study and previous research [34] suggest that Propofol blocks the V 1a and may be unsuitable as an anesthetic for future vasopressin receptor PET imaging in non-human primates. The high variability of the radiotracer uptake in the Saffan and ketamine experiments demonstrated that these two anesthetics are not benign for V 1a receptor imaging and different classes of anesthetics should be considered.…”

Section: Resultsmentioning

confidence: 45%

“…Previous research established that common animal anesthetics such as Propofol [34] and NMDA antagonists [35] interact with the vasopressin receptor system and alter the binding of V 1a receptors. Because in our lab we commonly use Propofol and an NMDA antagonist Ketamine as anesthetics for baboon PET imaging, we investigated an effect of these anesthetics and another common animal anesthetic Saffan on the brain regional biodistribution of [ 11 CH 3 ](1 S, 5 R )- 1 in mice.…”

Section: Resultsmentioning

confidence: 99%

Development of a radioligand for imaging V 1a vasopressin receptors with PET

Naik

Valentine

Hall

et al. 2017

European Journal of Medicinal Chemistry

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A series of vasopressin receptor V ligands have been synthesized for positron emission tomography (PET) imaging. The lead compound (1S,5R)-1 ((4-(1H-indol-3-yl)-3-methoxyphenyl) ((1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)methanone) and its F-ethyl analog 6c exhibited the best combination of high binding affinity and optimal lipophilicity within the series. (1S,5R)-1 was radiolabeled with C for PET studies. [CH](1S,5R)-1 readily entered the mouse (4.7% ID/g tissue) and prairie vole brains (∼2% ID/g tissue) and specifically (30-34%) labeled V receptor. The common animal anesthetic Propofol significantly blocked the brain uptake of [CH](1S,5R)-1 in the mouse brain, whereas anesthetics Ketamine and Saffan increased the uptake variability. Future PET imaging studies with V radiotracers in non-human primates should be performed in awake animals or using anesthetics that do not affect the V receptor.

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Effect of Propofol on Arachidonate Cascade by Vasopressin in Aortic Smooth Muscle Cells

Cited by 8 publications

References 42 publications

Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

Propofol and thiopental attenuate the contractile response to vasoconstrictors in human and porcine coronary artery segments

General Anesthetics and Vascular Smooth Muscle

Development of a radioligand for imaging V 1a vasopressin receptors with PET

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