Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (<i>Danio rerio</i>)

Teng, Miaomiao; Zhao, Feng; Zhou, Yanmin; Yan, Sen; Tian, Sinuo; Yan, Jin; Meng, Zhiyuan; Bi, Sheng; Wang, Chengju

doi:10.1021/acs.jafc.9b00449

Cited by 65 publications

(16 citation statements)

References 71 publications

(115 reference statements)

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“…Hernández-Moreno et al (2011) argue that there is a great variability in the results of LC50 found for different species and even within the same species, therefore, comparisons of results should be interpreted with caution to avoid erroneous conclusions possibly due to the applied test, the testing conditions, stage of life of the exposed organisms, among other factors. However, the fact is that concentrations found in the environment of 12.90 mg L − 1 can be very harmful to sh (Teng et al 2019).…”

Section: Discussionmentioning

confidence: 99%

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Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Henriques

Rezende

Castilho‐Barros

et al. 2021

Fish Physiol Biochem

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The objective of this study was to analyze the sublethal effects of propiconazole on Deuterodon iguape a native sh common in Brazil, which has potential for aquaculture and use as a bioindicator. The hypothesis was to test whether D. iguape has a metabolism similar to Danio rerio so that its use in bioassays may be validated. Lethal concentration (LC50) and metabolic rates were studied in sh exposed to propiconazole. There was an increase and decrease in the metabolic rate at 0.01 and 0.1 µg L -1 , with a statistical difference from the control ratio for the two species. The same trend towards ammonia excretion was observed, initially increasing to a concentration of 0.01 µg L -1 and then decreasing as the concentration of propiconazole was increased. The averages of speci c ammonia excretion in all concentrations were signi cantly different compared to the control. It was concluded that exposure to propiconazole increased the metabolic rates of D. Iguape and D. rerio, up to 0.05 µg L -1 , and decreased the rates when the concentration was doubled (0.1 µg L -1 ); causing serious problems in sh metabolism. D. iguape proved to be a good and useful bioindicator for ichthyologists or ecologists in studies of moderate pesticide contamination in freshwater aquatic environments, as its metabolic response was similar to D. rerio.

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Section: Discussionmentioning

confidence: 99%

“…The zebra sh, Danio rerio, is the model sh most used in bioassays on genetics, neurophysiology, and biomedicine (Amsterdam and Hopkins 2006;Teng et al 2019). Other important aspect in zebra sh is the transparent embryo for an easy teratogenesis assessment (Keshari et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Henriques

Rezende

Castilho‐Barros

et al. 2021

Fish Physiol Biochem

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“…In the hazard classification, propiconazole is classified as reproductive toxicity 1B category and belongs to endocrine disrupting substances [4]. Related studies have confirmed that propiconazole can result in genetic toxicity, liver toxicity and growth toxicity [5][6][7]. The U.S. Environmental Protection Agency has included propiconazole in the list of possible human carcinogens [8].…”

Section: Introductionmentioning

confidence: 99%

Antibody Generation and Rapid Immunochromatography Using Time-Resolved Fluorescence Microspheres for Propiconazole: Fungicide Abused as Growth Regulator in Vegetable

Chen

Shen

et al. 2022

Foods

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Propiconazole (PCZ) is a fungicide popularly used to prevent and control wheat and rice bakanae disease, etc. However, it was recently found to be illegally employed as a plant regulator to induce thick stems and dark green leaves of Brassica campestris, a famous vegetable in Guangdong, South China. Due to a lack of available recognition molecules to the target analyte, it is still a big challenge to establish a rapid surveillance screening method. In this study, a novel chiral hapten was rationally designed, and an artificial immunogen was then prepared for the generation of a specific antibody against propiconazole for the first time. Using the obtained antibody, a highly sensitive time-resolved fluorescence microspheres lateral flow immunochromatographic assay (TRFMs-LFIA) was established with a visual limit of detection of 100 ng/mL and a quantitative limit of detection of 1.92 ng/mL for propiconazole. TRFMs-LFIA also exhibited good recoveries ranging from 78.6% to 110.7% with coefficients of variation below 16%. The analysis of blind real-life samples showed a good agreement with results obtained using HPLC-MS/MS. Therefore, the proposed method could be used as an ideal screening surveillance tool for the detection of propiconazole in vegetables.

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“…In particular, its high homology with mammalian genes is favorable for assessing developmental toxicity and neurotoxicity of chemical substances (Jia et al, 2020;Shen et al, 2020b). Besides, using zebra sh embryos to address scienti c questions is more suitable to meet current legislation (Teng et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae

Shen

Zhao

et al. 2022

Environ Sci Pollut Res

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Propylene glycol (PG) is widely used in the foods, pharmaceuticals, oil industry, animal feed, cosmetics and other industries. Because of the existence of a chiral carbon center, PG forms R (Rectus)-and S (Sinister)-enantiomers. Currently, the toxicity study of its R-, S-enantiomers is still very scarce. In this study, we have assessed the developmental toxicity and neurotoxicity of the R-, S-, and RS-PG enantiomers in zebra sh larvae. We found that exposure to R-, S-, and RS-PG enantiomers did not signi cantly affect the basic developmental endpoints of embryos or larvae (i.e., embryonic movement, hatching, mortality, malformation, heartbeat, body length), indicating that R-, S-, and RS-PG exposures did not exhibit the basic developmental toxicity in zebra sh larvae. The toxicity of the three enantiomers was lower than that of ethanol, and there was no signi cant difference between them. However, R-, S-, and RS-PG exposures with high doses could signi cantly change the eye diameter and the locomotor activity of larval zebra sh, indicating that R-, S-, and RS-PG enantiomers of high doses can potentially exhibit the neurotoxicity and ocular developmental toxicity in zebra sh larvae. Therefore, the potential neurotoxicity and ocular developmental toxicity of R-, S-, and RS-PG enantiomers for infants and toddlers should be considered.

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Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio)

Cited by 65 publications

References 71 publications

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil

Antibody Generation and Rapid Immunochromatography Using Time-Resolved Fluorescence Microspheres for Propiconazole: Fungicide Abused as Growth Regulator in Vegetable

Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae

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