Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy

Ma, Yu; Li, Siwen; Ye, Shuzi; Hu, Die; Luo, Sijia; Wei, Lai; Xiao, Fang

doi:10.1016/j.fct.2022.113354

Cited by 3 publications

(1 citation statement)

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“…In vitro data have evidenced that pesticide exposure favors malign breast cancer cells' capabilities as migration, angiogenesis (15) and proliferation (16), which are biological features linked to highly aggressive breast tumors in humans. Also, in vitro data has pointed out the immunogenotoxicity of pesticides (16)(17)(18)(19). However, little is known regarding the relationship between pesticide exposure, breast cancer behavior and immune response.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Santos,

da Silva,

Jaques

et al. 2023

Front. Immunol.

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Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1β, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer.

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