Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes

Baumgartel, Kelley L.; Groër, Maureen; Cohen, Susan M.; Ren, Dianxu; Spatz, Diane L.; Conley, Yvette P.

doi:10.1177/0890334416646725

Cited by 3 publications

(10 citation statements)

References 74 publications

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“…For example, functioning FUT2 (secretors) is often reported as occurring in 80% of Caucasians (Azad et al, 2018) and as low as 11% of Koreans (Park et al, 2005). Allele frequency, which is closely tied to geographic location, contributes to human milk composition, including among mothers who deliver preterm (Baumgartel et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

The Human Milk Metabolome: A Scoping Literature Review

et al. 2023

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Background: Human milk is a complex source of nutrition and other bioactives that protects infants from disease, holding a lifetime of beneficial effects. The field of metabolomics provides a robust platform through which we can better understand human milk at a level rarely examined. Research Aim: To Identify, describe, synthesize, and critically analyze the literature within the past 5 years related to the human milk metabolome. Methods: We conducted a scoping literature review and quality analysis of the recent science reflecting untargeted metabolomic approaches to examining human milk. We searched six databases using the terms “breast milk,” “metabolome,” “metabolite,” and “human milk,” Out of more than 1,069 abstracts, we screened and identified 22 articles that met our inclusion criteria. Results: We extracted data related to the study author, geographic location, research design, analyses, platform used, and results. We also extracted data related to human milk research activities, including collection protocol, infant/maternal considerations, and time. Selected studies focused on a variety of phenotypes, including maternal and infant disease. Investigators used varying approaches to evaluate the metabolome, and differing milk collection protocols were observed. Conclusion: The human milk metabolome is informed by many factors—which may contribute to infant health outcomes—that have resulted in disparate milk metabolomic profiles. Standardized milk collection and storage procedures should be implemented to minimize degradation. Investigators may use our findings to develop research questions that test a targeted metabolomic approach.

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Section: Discussionmentioning

confidence: 99%

The Human Milk Metabolome: A Scoping Literature Review

et al. 2023

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“…Maternal genomic DNA was extracted from breast milk whey using Qiagen DNA Extraction Mini Kit (Baumgartel, 2016). We collected genotype data using TaqMan allele discrimination assays to genotype seven functional promoter polymorphisms of IL4 (rs2070874, rs2243250), IL6 (rs1800795, rs1800796), and IL10 (rs1800871, rs1800872, rs1800896).…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%

Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants

Baumgartel

Groër

Cohen

et al. 2016

Biological Research For Nursing

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Background Maternal interleukin (IL) single nucleotide polymorphisms (SNPs) are associated with obstetrical outcomes. Conversely, infant SNPs are associated with subsequent neonatal intensive care unit (NICU) outcomes. Little is known about relationships between maternal SNPs and neonatal outcomes. Purpose To examine the relationships between maternal IL genotypes and neonatal outcomes. Methods An ancillary study was conducted among mothers (N = 63) who delivered very low-birth-weight infants (N = 74). Maternal DNA was extracted from breast milk and genotyped. Outcomes included fecal calprotectin, length of stay, scores for neonatal acute physiology with perinatal extension (SNAPPE-II), weight gain, oxygen needs, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, retinopathy of prematurity, blood transfusions, and feeding intolerance. Multivariate analyses examined the relationships between maternal IL SNPs and outcomes, controlling for gestational age and the ratio of maternal milk to total milk. Results Absence of a minor allele in 2 IL6 SNPs was associated with fecal calprotectin (p = .0222, p = .0429), length of stay (p = .0158), SNAPPE-II (p = .0497), weight gain (p = .0272), and days on oxygen (p = .0316). IL6 genotype GG (rs1800795) was associated with length of stay (p = .0034) and calprotectin (p = .0213). Minor-allele absence in 2 IL10 SNPs was associated with days on oxygen (p = .0320). There were associations between IL10 genotype TT (rs1800871) and calprotectin (p = .0270) and between IL10 genotypes AA (rs1800872 and rs1800896) and calprotectin (p = .0158, p = .0045). Conclusion Maternal IL SNPs are associated with NICU outcomes. A potential clinical application includes an antenatal risk profile to identify neonatal needs.

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“…We sought to describe longitudinal cytokine and CRP MOM profiles, choosing MOM cytokines previously reported in the limited literature to be associated with maternal inflammation. These included IL-1β, IL-1ra, and IL-8 which have been associated with pre-eclampsia (Erbağcı et al, 2005); IL-6 and TNF-α, which may be associated with maternal body mass index (BMI), pre-eclampsia, and infant adiposity (Baumgartel et al, 2016;Erbağcı et al, 2005;Fujimori et al, 2015;Young et al, 2017;Zambruni et al, 2017); anti-inflammatory IL-10, which may correlate with NEC risk (Baumgartel et al, 2016); interferon (INF)-γ, which may upregulate proinflammatory cytokines (Chatterton et al, 2013) and is found in high levels in colostrum (Moles et al, 2015); and CRP, which has been studied in normal and overweight maternal populations (Fujimori et al, 2015(Fujimori et al, , 2017. Finally, we studied free choline, which may negatively correlate with MOM CRP (Ozarda et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…MOM cytokines and their potential effect on the infant are a relatively new area of research. The presence of both pro- and anti-inflammatory cytokines in MOM suggests specific biologic roles that remain to be elucidated, and limited studies suggest a potential association with infant outcomes ( Baumgartel et al, 2016 ). Although limited research has focused on term infants, MOM cytokines appear to change over time and vary by term versus preterm delivery ( Baumgartel et al, 2016 ; Chollet-Hinton et al, 2014 ; Groer et al, 2014 ; Ustundag et al, 2005 ) and by geographic or socioeconomic setting ( Ruiz et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…There is little published research specific to the MOM cytokine profile of parents who deliver very low birth weight (VLBW, < 1500 g) infants admitted to neonatal intensive care (NICU) settings, for whom maternal risk factors may vary significantly from term infants. Early delivery is common with maternal diagnoses associated with inflammation, such as obesity and pre-eclampsia ( Jayaram et al, 2020 ; Liu et al, 2019 ), which affect maternal serum cytokine profiles and inflammatory markers such as C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) ( Catalano & Shankar, 2017 ; Chen et al, 2017 ; Gaillard et al, 2016 ; Kwiatkowski et al, 2016 ; Liu et al, 2019 ; Shin et al, 2017 ), and plausibly could affect the MOM fed to these infants ( Baumgartel et al, 2016 ; Erbağcı et al, 2005 ; Fujimori et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants

Hoban,

Nir,

Somerset

et al. 2023

J Hum Lact

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Background: Mother’s breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population. Research Aim: To assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant’s stool calprotectin. Method: This is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein [CRP], IFN-γ, IL-10, IL-1β, IL-1ra, IL-6, IL-8, TNF-α). Infant stools were collected for longitudinal calprotectin analysis. Generalized estimating equations quantified longitudinal profiles of milk markers and stool calprotectin, their associations, and the correlation between free choline and C-reactive protein over follow-up. Result: Participants included 92 parents and infants (median weeks of gestation 27.3, median birth weight 845 g, and prevalence of male infants 45%). In all, 212 milk samples and 94 corresponding stool calprotectin levels were collected 1–11 weeks postpartum. C-reactive protein was present in much higher concentrations than other markers, and was highest in Week 1 postpartum. It decreased over time. IL-8 and free choline also changed over time while other markers did not. There was no correlation between any milk markers and stool calprotectin. Conclusion: Milk from mothers of very preterm infants has detectable inflammatory markers, some of which change over time. Research is needed to determine if infant outcomes are associated with these markers.

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Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes

Cited by 3 publications

References 74 publications

The Human Milk Metabolome: A Scoping Literature Review

The Human Milk Metabolome: A Scoping Literature Review

Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants

Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants

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