Effect of proinflammatory cytokines (IL-6, TNF-α, IL-1β) on hemodynamic performance during orthotopic liver transplantation

Arranz, J; Soriano, Antonio; García, Irene Carrasco; Concepción, Mar; Navarro, Javier; Arteaga, Alejandro Sánchez; Filella, Xavier; Bravo, Paloma; Barrera, María-José; Escribano, S.; Jiménez, Ana Gabriela; Moneva, E; Fernández, Joaquín; Varona, Alejandro García; Herrero, E; Domı́nguez, David

doi:10.1016/s0041-1345(03)00603-1

Cited by 43 publications

(31 citation statements)

References 16 publications

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“…These adipose tissue macrophages (ATMs) are currently considered to be a major cause of obesity-associated chronic low-grade inflammation via the secretion of a wide variety of inflammatory molecules [1,2], including TNF-α, IL-6 [3] and monocyte chemoattractant protein-1 (MCP-1). These inflammatory molecules may have local effects on white adipose tissue (WAT) physiology as well as potential systemic effects on other organs that culminate in insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

et al. 2012

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Aims/hypothesis Monocyte chemoattractant protein-1 (MCP-1)/chemokine (C-C motif) ligand (CCL) 2 (CCL2) secreted from white adipose tissue (WAT) in obesity has been reported to contribute to tissue macrophage accumulation and insulin resistance by inducing a chronic inflammatory state. MCP-1 has been shown to be elevated in the fatty liver of lipoatrophic A-ZIP-transgenic (A-ZIP-Tg) mice. Treatment of these mice with the CC chemokine receptor (CCR) 2 antagonist has been shown to ameliorate the hyperglycaemia, hyperinsulinaemia and hepatomegaly, in conjunction with reducing liver inflammation. However, since CCR2 antagonists can block not only MCP-1 but also MCP-2 (CCL8) and MCP-3 (CCL7), it remains unclear whether MCP-1 secreted from the liver could contribute to hyperglycaemia, hyperinsulinaemia and hepatomegaly in conjunction with liver inflammation, as well as to the M1 and M2 states of macrophage polarisation. Methods To address these issues, we analysed the effects of targeted disruption of MCP-1 in A-ZIP-Tg mice. Results MCP-1 deficiency alone or per se resulted in a significant amelioration of insulin resistance in A-ZIP-Tg mice, which was associated with a suppression of extracellular signal-regulated protein kinase (ERK)-1/2 and p38 mitogen-activated protein kinase (p38MAPK) phosphorylation in liver. Although MCP-1 deficiency did not reduce the expression of macrophage markers, it increased the expression of the genes encoding M2 macrophage markers such as Arg1 and Chi3l3, as well as significantly reducing the triacylglycerol content of livers from A-ZIP-Tg mice. Conclusions/ interpretation Our data clearly indicated that MCP-1 deficiency improved insulin resistance and hepatic steatosis in A-ZIP-Tg mice and was associated with switching macrophage polarisation and suppressing ERK-1/2 and p38MAPK phosphorylation.

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Section: Introductionmentioning

confidence: 99%

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

et al. 2012

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“…Previous cardiac conditions may influence the outcomes of transplant, so thorough evaluation prior to LT is recommended. Furthermore, the surgical procedure on its own, which involves acute changes in loading conditions and the liberation of cytokines and toxins associated with reperfusion, has a documented influence on heart function [4][5][6]. Lastly, after LT there is an increased risk of cardiac events associated with life-long immunosuppression and its secondary effects.…”

Section: Introductionmentioning

confidence: 99%

The heart in liver transplantation

Ripoll

Yotti

Bermejo

et al. 2011

Journal of Hepatology

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The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associated conditions. Furthermore, liver transplantation is one of the most cardiovascular stressful events that a patient with cirrhosis may undergo. After liver transplantation, the progression of pre-existing or the development of new-onset cardiac disease may occur. This article reviews the relationship between the heart and liver transplantation in the pre-transplant, intra-operative, and post-transplant periods.

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“…Santiago and associates 4 found that TNF-s and IL-10 levels gradually increased as the operation progressed and reached their maximums after reperfusion, which also was true in our study. Boros and associates 22 and Arranz and associates 23 reported that TNF-α and IL-1 did not rise significantly until reperfusion, and that the IL-6 level showed a sharp rise after the initiation of surgery. In our study, TNF-α concentration increased after reperfusion, and the IL-6 level increased as much as 40 times during anhepatic stage compared with values before surgery, which was similar to the above-mentioned authors' results.…”

Section: Discussionmentioning

confidence: 98%

Proinflammatory and Anti-Inflammatory Cytokine Balance in Patients With Cirrhotic Hepatitis During Live-Donor Liver Transplant

Koh

Joo²,

Cho³

et al. 2012

Exp Clin Transplant

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Objectives: The immune system releases cytokines during the stress response, and the balance between proinflammatory and anti-inflammatory cytokines is important. This prospective study was done to determine which cytokines are responsible for maintaining cytokine balance during live-donor liver transplant surgery. Materials and Methods: Recipients undergoing livedonor liver transplant surgery due to cirrhotic hepatitis were allocated to a recipient group (n=44), and healthy donors were placed in the donor group (n=45). In donors, blood sampling for cytokine level analysis was performed after anesthetic induction (before the start of surgery, time point 1). In recipients, blood samples were collected before the start of surgery (time point 1), 60 minutes after the start of the anhepatic period (time point 2), and 60 minutes after reperfusion (time point 3). The proinflammatory cytokines measured were interleukin-1β, interleukin-6, and tumor necrosis factor-α; the anti-inflammatory cytokines were interleukin-10 and interleukin-4. Cytokines were quantified using sandwich enzyme-linked immunoassays. The time course of proinflammatory and anti-inflammatory cytokine concentrations during surgery in the recipient group was evaluated.Results: Interleukin-6, interleukin-10 and tumor necrosis factor-α showed significant changes in concentration during surgery, with interleukin-6 reaching levels 40 times higher than the preoperative value at the anhepatic stage. Interleukin-10 reached a peak at the neohepatic phase, with values 60 times higher than the preoperative value. The preoperative concentrations of interleukin-6 and interleukin-10 in the recipient group were higher than those in the donor group with a median of 4.48 vs 1.98 pg/mL (P < .001) and 2.98 vs 1.22 (P = .026). Conclusions: Interleukin-6 and interleukin-10 play a major role in cytokine balance before and during live-donor liver transplant surgery.

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Effect of proinflammatory cytokines (IL-6, TNF-α, IL-1β) on hemodynamic performance during orthotopic liver transplantation

Cited by 43 publications

References 16 publications

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

The heart in liver transplantation

Proinflammatory and Anti-Inflammatory Cytokine Balance in Patients With Cirrhotic Hepatitis During Live-Donor Liver Transplant

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