Effect of Prograf (FK506) on spermatogenesis in rats

Structural alterations in the seminiferous tubules of rats treated with immunosuppressor tacrolimus

“…However, data regarding the effect of FK-506 on the seminiferous tubules have not been found in the literature. In contrast to the findings of the previous study [ 19 ], significant alterations were observed in the seminiferous epithelium of the rats treated with 1 mg/kg/day of tacrolimus during 30 and 60 days. These differences could be due to the long periods of treatment evaluated in this study, in contrast to the short period [ 19 ].…”

“…Similar to previous findings [ 19 , 32 ], the results revealed a significant reduction in the body weight of rats from treated groups. Regarding the effect of tacrolimus on the spermatogenesis, the treatment of rats with 1 or 3 mg/kg/day of tacrolimus (FK-506) for 2 weeks leads to sperm counts and motility decrease.…”

Structural alterations in the seminiferous tubules of rats treated with immunosuppressor tacrolimus

“…However, data regarding the effect of FK-506 on the seminiferous tubules have not been found in the literature. In contrast to the findings of the previous study [ 19 ], significant alterations were observed in the seminiferous epithelium of the rats treated with 1 mg/kg/day of tacrolimus during 30 and 60 days. These differences could be due to the long periods of treatment evaluated in this study, in contrast to the short period [ 19 ].…”

“…Similar to previous findings [ 19 , 32 ], the results revealed a significant reduction in the body weight of rats from treated groups. Regarding the effect of tacrolimus on the spermatogenesis, the treatment of rats with 1 or 3 mg/kg/day of tacrolimus (FK-506) for 2 weeks leads to sperm counts and motility decrease.…”

TUNEL analysis of sperm DNA fragmentation in kidney transplant patients

“…In these patients, the DNA damage amount of the spermatozoa can be interpreted as a considerable factor for unsuccessful reproductive treatment or infertility even if the sperm DNA fragmentation of the kidney transplant patients was not significantly higher compared to the controls (P = 0.09) [17]. For our patient population, the DNA fragmentation percentage was 17.8% ± 14.1 in the transplantation group and 16.5% ± 6.5 in the control group (P = 0.1), which was lower than the threshold value for infertility (20.05% by TUNEL assay) reported elsewhere [18,19].…”

Immunosuppressant Prograf® (Tacrolimus) Induces Histopathological Disorders in the Peritubular Tissue of Rat Testes

“…In untreated female rats that mated with tacrolimus-treated male rats for 2 weeks, the number of live fetuses and the embryonic implantation index were reduced due to a decrease in the number and motility of the spermatozoa [Hisatomi et al, 1996]. Thus, the authors have concluded that these alterations were related to a possible effect of tacrolimus on the epididymis.…”

Structural alterations in the seminiferous tubules of rats treated with immunosuppressor tacrolimus

“…However, data regarding the effect of FK-506 on the seminiferous tubules have not been found in the literature. In contrast to the findings of the previous study [ 19 ], significant alterations were observed in the seminiferous epithelium of the rats treated with 1 mg/kg/day of tacrolimus during 30 and 60 days. These differences could be due to the long periods of treatment evaluated in this study, in contrast to the short period [ 19 ].…”

“…Similar to previous findings [ 19 , 32 ], the results revealed a significant reduction in the body weight of rats from treated groups. Regarding the effect of tacrolimus on the spermatogenesis, the treatment of rats with 1 or 3 mg/kg/day of tacrolimus (FK-506) for 2 weeks leads to sperm counts and motility decrease.…”

TUNEL analysis of sperm DNA fragmentation in kidney transplant patients

“…In these patients, the DNA damage amount of the spermatozoa can be interpreted as a considerable factor for unsuccessful reproductive treatment or infertility even if the sperm DNA fragmentation of the kidney transplant patients was not significantly higher compared to the controls (P = 0.09) [17]. For our patient population, the DNA fragmentation percentage was 17.8% ± 14.1 in the transplantation group and 16.5% ± 6.5 in the control group (P = 0.1), which was lower than the threshold value for infertility (20.05% by TUNEL assay) reported elsewhere [18,19].…”

Immunosuppressant Prograf® (Tacrolimus) Induces Histopathological Disorders in the Peritubular Tissue of Rat Testes

“…In untreated female rats that mated with tacrolimus-treated male rats for 2 weeks, the number of live fetuses and the embryonic implantation index were reduced due to a decrease in the number and motility of the spermatozoa [Hisatomi et al, 1996]. Thus, the authors have concluded that these alterations were related to a possible effect of tacrolimus on the epididymis.…”

Structural alterations in the seminiferous tubules of rats treated with immunosuppressor tacrolimus

“…However, data regarding the effect of FK-506 on the seminiferous tubules have not been found in the literature. In contrast to the findings of the previous study [ 19 ], significant alterations were observed in the seminiferous epithelium of the rats treated with 1 mg/kg/day of tacrolimus during 30 and 60 days. These differences could be due to the long periods of treatment evaluated in this study, in contrast to the short period [ 19 ].…”

“…Similar to previous findings [ 19 , 32 ], the results revealed a significant reduction in the body weight of rats from treated groups. Regarding the effect of tacrolimus on the spermatogenesis, the treatment of rats with 1 or 3 mg/kg/day of tacrolimus (FK-506) for 2 weeks leads to sperm counts and motility decrease.…”

TUNEL analysis of sperm DNA fragmentation in kidney transplant patients

“…In these patients, the DNA damage amount of the spermatozoa can be interpreted as a considerable factor for unsuccessful reproductive treatment or infertility even if the sperm DNA fragmentation of the kidney transplant patients was not significantly higher compared to the controls (P = 0.09) [17]. For our patient population, the DNA fragmentation percentage was 17.8% ± 14.1 in the transplantation group and 16.5% ± 6.5 in the control group (P = 0.1), which was lower than the threshold value for infertility (20.05% by TUNEL assay) reported elsewhere [18,19].…”

Immunosuppressant Prograf® (Tacrolimus) Induces Histopathological Disorders in the Peritubular Tissue of Rat Testes

“…In untreated female rats that mated with tacrolimus-treated male rats for 2 weeks, the number of live fetuses and the embryonic implantation index were reduced due to a decrease in the number and motility of the spermatozoa [Hisatomi et al, 1996]. Thus, the authors have concluded that these alterations were related to a possible effect of tacrolimus on the epididymis.…”