Effect of progesterone on colonic motility and fecal output in mice with diarrhea

Li, C. P.; Ling, Chien; Biancani, Piero; Behar, José

doi:10.1111/j.1365-2982.2011.01875.x

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…This inhibitory effect of PROG was supported by other studies on GIT [35][36][37]. In consistency with our findings, this rapid inhibitory effect has only been seen with high concentrations of PROG that do not occur in vivo [39].…”

Section: Discussionsupporting

confidence: 93%

Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats

Rezk¹

2017

AJIM

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Sex differences were reported in Irritable Bowel Syndrome. We aimed to demonstrate the effect of gonadal hormones on colonic contractile activity. In this study, we performed in vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Albino rats. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed. We found that increasing doses of EST resulted in a stepwise inhibition of SCCA in both sexes and inhibited the ACh effect in females. Similarly, high dose PROG inhibited SCCA in females. TEST inhibited SCCA in males but not Ach induced contractions. TEST reduced the inhibitory effect of NE in female rats. In conclusion, exposure of colonic smooth muscle strips to gonadal hormones led to sex-dependent changes in SCCA and modified the response of smooth muscle strips to both pro-contractile and anti-contractile neurotransmitters.

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Section: Discussionsupporting

confidence: 93%

Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats

Rezk¹

2017

AJIM

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“…An inhibitory effect of PROG has been reported for colonic, gastric and gall bladder smooth muscle . PROG rapidly decreases the tension of intestinal smooth muscle strips in vitro and high concentrations can completely inhibit the SCCA .…”

Section: Discussionsupporting

confidence: 92%

In vitro spontaneous contractile activity of colonic smooth muscle in naive Lewis rats: Acute effect of gonadal hormones

Baumgartner

Hubacher

Krayer

et al. 2017

J of Digest Diseases

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Objective Functional gastrointestinal disorders affect females more often. Changes in colonic motility may be etiological co‐factors for the clinical symptoms. The aim of the present study was to analyze the influence of gonadal hormones on colonic contractile activity. Methods In vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Lewis rats were performed in an organ chamber experiment. After the administration of a gonadal hormone estradiol [EST], progesterone [PROG] and testosterone [TEST]) or ethanol solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed. Results Compared to the smooth muscle strips of male rats, significantly higher spontaneous colonic contractile activity (SCCA) was observed in female animals. Increasing doses of ACh showed the progressive stimulation of SCCA whereas rising doses of NE resulted in a stepwise inhibition of SCCA, respectively. EST superfusion displayed an inhibitory effect on SCCA in both sexes and inhibited the ACh effect in female rats. Similarly, acute superfusion with high‐dose PROG inhibited SCCA in females. Acute TEST superfusion inhibited SCCA in males and led to significant higher colonic contractile activity in males following subsequent stimulation with ACh. In female rats, the inhibitory effect of NE was reduced by prior exposure to TEST. Conclusion In our in vitro study the acute exposure of colonic smooth muscle tissue to gonadal hormones led to sex‐dependent changes in SCCA and translated in a modified response of smooth muscle strips to both pro‐contractile and anti‐contractile neurotransmitters.

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“…The colonic transit time is longer during the luteal phase (high progesterone) when compared to the follicular phase (low progesterone) (Wald et al, 1981;Jung et al, 2003). Progesterone also impairs smooth muscle contraction (Xiao et al, 2009;Li et al, 2012) and downregulates the barrier function of tight Acta Neuropsychiatrica junctions which may contribute to cytoskeletal remodeling (Someya et al, 2013) in uterine endometrium. Progesterone promotes endometrial remodeling via modifications of actin fibres architecture, which leads to cell membrane reshaping and movement (Pfaendtner et al, 2010;Shortrede et al, 2018;Svitkina, 2018).…”

Section: Discussionmentioning

confidence: 99%

The menstrual cycle may not be limited to the endometrium but also may impact gut permeability

Roomruangwong

Carvalho

Geffard³

et al. 2019

Acta Neuropsychiatr.

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Objective:To examine associations between IgA responses to Gram-negative gut commensal bacteria and peri-menstrual symptoms and sex hormone levels during the menstrual cycle in women with and without premenstrual symptoms.Methods:Forty women aged 18–45 years completed the Daily Record of Severity of Problems (DRSP) during all 28 consecutive days of the menstrual cycle. We assayed, in plasma, IgA responses to six Gram-negative bacteria, that is, Hafnei alvei, Pseudomonas aeruginosa, Morganella morganii, Klebsiella pneumoniae, Pseudomonas putida and Citobacter koseri, progesterone and oestradiol at days 7, 14, 21 and 28 of the menstrual cycle.Results:Significant changes in Δ (actual − 1 week earlier) IgA to lipopolysaccharides (LPS) of the six Gram-negative bacteria during the menstrual cycle were observed with peak IgA levels at T4 (day 28) and lows at T1 or T2 (day 7 or 14). The ΔIgA changes in H. alvei, M. Morganii, P. putida during the menstrual cycle were significantly and positively associated with changes in the total DRSP score, and severity of physio-somatic, anxiety and breast-craving, but not depressive, symptoms. The changes in IgA responses to LPS were largely predicted by changes in progesterone and steady-state levels of progesterone averaged over the luteal phase.Discussion:Menstrual cycle-associated changes in IgA directed against LPS and by inference bacterial translocation may be driven by the effects of progesterone on transcellular, paracellular and vascular pathways (leaky gut) thereby contributing to the severity of physio-somatic and anxiety symptoms as well as fatigue, breast swelling and food cravings.

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Effect of progesterone on colonic motility and fecal output in mice with diarrhea

Abstract: Progesterone decreased the contractility of circular muscle strips, and reduced the fecal output in two diarrheal models, the SERT-KO and fluoxetine-treated mice.

Cited by 14 publications

References 29 publications

Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats

Effect of Gonadal Hormones on Colonic Contractile Activity in Albino Rats

In vitro spontaneous contractile activity of colonic smooth muscle in naive Lewis rats: Acute effect of gonadal hormones

The menstrual cycle may not be limited to the endometrium but also may impact gut permeability

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