Effect of Progestational Agents on Gonadal and Adrenal Cortical Function in Patients with Benign Prostatic Hypertrophy and Carcinoma of the Prostate

YTTRIUM90PITUITARY ABLATION IN ADVANCED CARCINOMA OF THE PROSTATE

“…castration, there is a temporary decrease in the level of 17-ketosteroids in the urine, but these levels rise after variable periods of time (Tamm et al, 1965;Wilkins, 1966). A similar response has been observed after the administration of estrogens (Burt et al, 1957;Geller et al, 1967).…”

“…castration, there is a temporary decrease in the level of 17-ketosteroids in the urine, but these levels rise after variable periods of time (Tamm et al, 1965;Wilkins, 1966). A similar response has been observed after the administration of estrogens (Burt et al, 1957;Geller et al, 1967).The concept that other glands ,may play a role in the function of the prostate gland had led to the use of adrenalectomy (Morales et al, 1955) and hypophyseal ablation (Fergusson and Phillips, 1962;Fergusson, 1968) in the treatment of relapsing carcinoma of the prostate.The purpose of this paper is to report the experience with a group of 23 patients treated by Yttrium'" hypophysectomy for late carcinoma of the prostate.…”

Pills for the Benign Prostate

“…Based upon the somewhat shaky premise that benign prostatic hypertrophy is a result of changes in the hormonal milieu, androgens (Day 1939, Kahle & Maltry 1940, cestrogens (Roberts 1966, Cook 1963) and progestogens (Geller et al 1967, Wolf & Madsen 1968) have been tried, but the results were confusing due to the methods by which the drugs were assessed.…”

The Ultrastructure of the Accessory Sex Organs of the Male Rat

“…Although it has been reported that progestational agents regularly decreased plasma content of testosterone to a significant extent (Geller et al 1967), the relationship of the altered testosterone levels to clinical and histological changes remains to be shown, and a possible direct effect on the prostate has not been adequately studied (Geller et al 1969). By using previous results obtained in our laboratory (e. g., Dahl Se Kjaerheim 1974) as a baseline, it has been possible to demonstrate definite alterations of the ultrastructure of the accessory sex organs of the male rat after administration of chlormadinon acetate.…”