Effect of Profound Hypothermia on Immune Activation in a Swine Model of Lethal Hemorrhage

Alam, Hasan B.; Chen, H; Honma, Kaneatsu; Koustova, Elena; Rhee, Peter; Blecken, S. R.; Chen, Z

doi:10.1097/00024382-200403001-00275

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Profound Hypothermia For Lethal Shock1

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2005

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“…With funding from the National Institutes of Health, we are now performing a series of experiments to answer these questions in anticipation of clinical trials. We have already determined that optimal outcome is achieved when profound hypothermia is induced rapidly (2°C/minute) [63,64] and reversed at a rate of 0.5°C/minute. At present this concept is not suitable for application in a combat environment because of obvious logistical and legal constraints, but it is ready for testing in selected patients at large trauma centers.…”

Section: Profound Hypothermia For Lethal Shockmentioning

confidence: 99%

Combat Casualty Care Research: From Bench to the Battlefield

2005

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Hemorrhagic shock is the leading cause of death in civilian and combat trauma. Effective hemorrhage control and better resuscitation strategies have the potential of saving lives. The Trauma Readiness and Research Institute for Surgery (TRRI-Surg) was established to address the core mission of the Uniformed Services University, "Learning to Care for Those in Harm's Way," by conducting research to improve the outcome of combat casualties. This article highlights the salient achievements of this research effort in the areas of hemorrhage control, resuscitation, design and testing of devices, and some novel concepts such as the use of profound hypothermia. The impact of these basic science research findings on changes in military medical care and outcome of injured soldiers is also described.

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Section: Profound Hypothermia For Lethal Shockmentioning

confidence: 99%