Effect of processed aloe vera gel on immunogenicity in inactivated quadrivalent influenza vaccine and upper respiratory tract infection in healthy adults: A randomized double-blind placebo-controlled trial

Hwang, Jeong‐Hwan; Oh, Mi‐Ra; Hwang, Jang Yeon; Choi, Eun‐Kyung; Song, Eun-Jung; Españo, Erica; Webby, Richard J.; Webster, Robert G.; Kim, Jeong-Ki; Chae, Soo‐Wan

doi:10.1016/j.phymed.2021.153668

Cited by 2 publications

(1 citation statement)

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“…Although a number of animal studies indicate the viral vaccine adjuvant potential of AVG, we only know of one exploratory trial in humans so far. Oral intake of PAG (8 weeks) that overlapped with quadrivalent influenza vaccination (week 4) did not significantly increase vaccine seroprotectivity among healthy adults [ 84 ]. However, the geometric mean fold increase in antibody titers among patients at 4 weeks post-vaccination relative to baseline was significantly higher in the PAG group than in the placebo group.…”

Section: Aloe Compounds For the Regulation Of Immune Respons...mentioning

confidence: 99%

Utilization of Aloe Compounds in Combatting Viral Diseases

Españo

Kim

2022

Pharmaceuticals

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Plants contain underutilized resources of compounds that can be employed to combat viral diseases. Aloe vera (L.) Burm. f. (syn. Aloe barbadensis Mill.) has a long history of use in traditional medicine, and A. vera extracts have been reported to possess a huge breadth of pharmacological activities. Here, we discuss the potential of A. vera compounds as antivirals and immunomodulators for the treatment of viral diseases. In particular, we highlight the use of aloe emodin and acemannan as lead compounds that should be considered for further development in the management and prevention of viral diseases. Given the immunomodulatory capacity of A. vera compounds, especially those found in Aloe gel, we also put forward the idea that these compounds should be considered as adjuvants for viral vaccines. Lastly, we present some of the current limitations to the clinical applications of compounds from Aloe, especially from A. vera.

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Section: Aloe Compounds For the Regulation Of Immune Respons...mentioning

confidence: 99%