Effect of procainamide on dispersion of ventricular refractoriness

Shechter, Jay A.; Caine, Ruth; Friehling, Ted D.; Kowey, Peter R.; Engel, Toby R.

doi:10.1016/0002-9149(83)90122-4

Cited by 13 publications

(2 citation statements)

References 10 publications

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“…Numerous clinical studies, using mostly ECGs composed of nonsimultaneously recorded leads, have recently suggested that increased QT dispersion is associated with higher susceptibility to ventricular arrhythmias. [9][10][11][12][13][14][15][16][17][18][19] However, the predictive value of this parameter varies from study to study and so does the spectrum of "normal" and "abnormal" values. QT dispersion was found poorly reproducible between subsequent recordings and between observers.…”

Section: Qt Interval Dispersionmentioning

confidence: 99%

“…and its dispersion has been demonstrated in several clinical studies, especially in the postmyocardial infarction population. [9][10][11][12][13][14][15][16][17][18][19][20] However, other studies showed contradictory results and the spectrum of reported values for QT dispersion varies substantially. Moreover, concerns have been raised about the reproducibility of the measurement of QT interval dispersion.…”

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confidence: 99%

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Impact of Electrocardiogram Recording Format on QT Interval Measurement and QT Dispersion Assessment

Faber

Kautzner

Zehender

et al. 2001

Pacing Clinical Electrophis

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The aim of this study was to determine the effect of recording conditions on the operator dependent measures of QT dispersion in patients with known and/or suspected repolarization abnormalities. Among several methods for risk stratification, QT dispersion has been suggested as a simple estimate of repolarization abnormalities. In a cohort of high and low risk patients, different components of the repolarization process were assessed in the 12-lead ECG using three different paper speeds and amplifier gains. To assess measurement error and reproducibility, a straight line was repeatedly measured. The operator error was 0.675 +/- 0.02 mm and the repeatability of the measurement error was 31 +/- 6%. The QT interval was most frequently measurable in V2-V5. Depending on the lead selected for analysis, the incidence of visible U waves was greatest in the precordial leads with high amplifier gain and low paper speed, strongly affecting QT interval measurement. The timing of the onset of the QRS complex (QRS onset dispersion) or offset of the T wave was strongly dependent on the paper speed. Paper speed, but not amplifier gain, had a significant shortening effect on the measurement of the maximum QT interval. As QT interval measurement in each ECG lead incorporates QRS onset and T wave offset (depending on the number of visible U waves), the dispersion of each of these parameters significantly affected QT dispersion. Thus, QT dispersion appears to reflect merely the presence of more complex repolarization patterns in patients at risk of arrhythmias.

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