Effect of probiotics on metabolic profiles in type 2 diabetes mellitus

Li, Caifeng; Li, Xin; Han, Haifeng; Cui, Hailong; Peng, Min; Wang, Guolin; Wang, Zhiqiang

doi:10.1097/md.0000000000004088

Cited by 85 publications

(69 citation statements)

References 44 publications

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“…Numerous meta‐analyses suggest a beneficial effect of probiotics on glycaemic control in people with T2D . However, there is no consensus on the specific metabolic effect associated with supplementation.…”

Section: The Role Of Gut Microbiome In Obesity and Diabetesmentioning

confidence: 99%

Obesity and diabetes—Not only a simple link between two epidemics

Chobot¹,

Górowska-Kowolik²,

Sokołowska

et al. 2018

Diabetes Metabolism Res

195

129

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SummaryDiabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM—type 2 diabetes—but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut microflora, its interaction with the whole organism, and its role in the development of obesity and type 1 diabetes as well as type 2 diabetes are still not fully understood and subject of ongoing investigations. This review presents a summary of recently published results concerning the relation of obesity/overweight and DM as well as their associations with the microbiome.

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Section: The Role Of Gut Microbiome In Obesity and Diabetesmentioning

confidence: 99%

Obesity and diabetes—Not only a simple link between two epidemics

Chobot¹,

Górowska-Kowolik²,

Sokołowska

et al. 2018

Diabetes Metabolism Res

195

129

View full text Add to dashboard Cite

show abstract

“…Other proposed mechanisms are related to improved intestinal permeability, regulation of the immune system, and reduction of Toll-like receptor 4 signalling. In their meta-analysis, Li et al reported significant reduction in fasting blood glucose levels, following probiotics-intervention, in patients with type 2 diabetes [28]. However, no effect was observed in HbA 1c .…”

Section: Discussionmentioning

confidence: 99%

“…According to one meta-analysis of randomized controlled trials in type 2 diabetes, probiotics-intervention increased HDL-cholesterol concentration, but had no significant effect on LDL-cholesterol, total cholesterol or triglyceride concentration [28]. Another meta-analysis of randomized controlled trials among subjects with high, borderline high, or normal cholesterol levels, reported significant reductions in total cholesterol and LDL-cholesterol concentrations, but found no effects in HDL-cholesterol and triglyceride concentrations [20].…”

Section: Discussionmentioning

confidence: 99%

“…The exact mechanisms by which probiotics could affect glycaemia, is not known. However, it has been speculated that beneficial gut bacteria could increase the secretion of glucagon-like peptide 1 which would subsequently improve carbohydrate metabolism [28]. Other proposed mechanisms are related to improved intestinal permeability, regulation of the immune system, and reduction of Toll-like receptor 4 signalling.…”

Section: Discussionmentioning

confidence: 99%

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The Self-reported Use of Probiotics is Associated with Better Glycaemic Control and Lower Odds of Metabolic Syndrome and its Components in Type 1 Diabetes

Ahola¹,

Harjutsalo²,

Forsblom³

et al. 2017

J Prob Health

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In type 1 diabetes, various metabolic disturbances are frequently observed. Importantly, these may negatively affect individuals' long-term health outcomes. The use of probiotics has, in other populations, been beneficially associated with many of these risk factors. We, therefore, assessed the cross-sectional associations between the use of probiotics-containing food products or supplements and various health markers in a large population of individuals with type 1 diabetes.Included were 1039 individuals (mean age 46 ± 14 years, 45% men) with type 1 diabetes and without end-stage renal disease. Based on the entries in the diet questionnaire and the food record, participants were divided into those using (Probiotics yes ) and not using (Probiotics no ) probiotics-containing products. Various standard health markers, such as weight, waist circumference, blood pressure, blood lipids, and HbA 1c , were measured during the study visit.In all, 403 (39%) individuals reported using probiotics. Adjusted with potential confounders, the rate of overweight/ obesity, body mass index, and waist-to-hip ratio were higher in the Probiotics no group. Moreover, the odds of metabolic syndrome, and its waist, blood pressure, HDL-cholesterol, and triglyceride components were higher amongst those not using probiotics. In the normal-weight individuals, using probiotics was associated with significantly better glycaemic control.Using probiotics-containing food products or supplements may beneficially affect many of the traditional risk factors related to the diabetic complications. Randomized controlled trials are required to verify these observations.

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“…More recently, the use of probiotics to improve metabolic profiles (21,22), and reduce inflammatory factors (23)(24)(25) and oxidative stress biomarkers (26,27) has been investigated. Microbes in the gut contribute to extraction of energy from food and should be considered an environmental factor involved in obesity and related disabilities, such as insulin resistance, diabetes, and cardiovascular disease (28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%