Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis

Cao, Qing; Yu, Chengbo; Yang, Shigui; H, Cao; Chen, Ping; Deng, Min; Li, Lanjuan

doi:10.1016/j.hbpd.2018.01.005

Cited by 52 publications

(44 citation statements)

References 17 publications

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“…Although various drugs have been given for patients with MHE [39][40][41][42][43] to decrease ammonia levels or improve mental status, drugs that are effective against MHE are unclear. We showed that the concentration of BCAA correlated with the presence of MHE, suggesting that administration of BCAA may be a reasonable treatment for MHE, because of its potential e cacy ameliorating skeletal muscle mass loss.…”

Section: Discussionmentioning

confidence: 99%

Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

Tateyama

Naoe

Tanaka³

et al. 2020

Preprint

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Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy.Methods: To clarify the relationship between minimal hepatic encephalopathy and sarcopenia and/or muscle mass loss in patients with liver cirrhosis. Ninety-nine patients with liver cirrhosis were enrolled. Minimal hepatic encephalopathy was diagnosed by a neuropsychiatric test. Skeletal mass index was calculated by dividing muscle area at the third lumbar vertebra by the square of height in meters.Results: MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. Skeletal muscle index was smaller in patients with minimal hepatic encephalopathy (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Skeletal muscle index represented a predictive factor related to minimal hepatic encephalopathy (<50 cm2/m2; odds ratio 0.300, P = 0.002).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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Section: Discussionmentioning

confidence: 99%

Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

Tateyama

Naoe

Tanaka³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Although various drugs have been given for patients with MHE [40][41][42][43][44] to decrease ammonia levels or improve mental status, drugs that are effective against MHE are unclear. We showed that the concentration of BCAA correlated with the presence of MHE, suggesting that administration of BCAA may be a reasonable treatment for MHE, because of its potential e cacy ameliorating skeletal muscle mass loss.…”

Section: Discussionmentioning

confidence: 99%

Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study

Tateyama

Naoe

Tanaka³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy (MHE).Methods: To clarify the relationship between MHE and sarcopenia and/or muscle mass loss in patients with liver cirrhosis.Methods: Ninety-nine patients with liver cirrhosis were enrolled. MHE was diagnosed by a neuropsychiatric test. Skeletal mass index (SMI) and Psoas muscle index (PMI) were calculated by dividing skeletal muscle area and psoas muscle area at the third lumbar vertebra by the square of height in meters, respectively, to evaluate muscle volume.Results: This study enrolled 99 patients (61 males, 38 females). MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. SMI was smaller in patients with MHE (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Similarly, PMI was smaller in patients with MHE (4.24 cm2/m2) than in those without (5.53 cm2/m2, P = 0.003). Skeletal muscle volume, which is represented by SMI or PMI was a predictive factor related to MHE (SMI ≥ 50 cm2/m2; odds ratio 0.300, P = 0.002, PMI ≥ 4.3 cm2/m2; odds ratio 0.192, P = 0.001).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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“…A meta-analysis found that probiotics can decrease serum ammonia and endotoxin levels, improve minimal HE, and prevent overt HE development in cirrhosis. 35 Patients with acute alcoholic hepatitis (AAH) have been reported to have an over-representation of Enterococcus faecalis within their gut microbiota, with this species secreting a toxin called cytolysin which drives hepatocyte death and liver injury. 36 Using humanised mice in the same study, bacteriophages, which are viruses that destroy bacteria with high specificity, were targeted against E faecalis; this resulted in decreased cytolysin in the liver and abolished ethanol-induced liver disease.…”

Section: Manipulating the Gut Microbiota And Gut-liver Axis In Cirrhosismentioning

confidence: 99%

Modulating the gut–liver axis and the pivotal role of the faecal microbiome in cirrhosis

2020

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Cirrhosis is associated with intestinal dysbiosis, with specific alterations in the gut microbiota linked to particular aetiologies and manifestations of the disease. We review the role of the gut microbiome and the importance of the intestinal barrier in cirrhosis, provide an overview of the terminology and techniques relevant to this emerging area, and discuss the latest developments in therapies targeting the gut-liver axis.

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Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis

Cited by 52 publications

References 17 publications

Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study

Modulating the gut–liver axis and the pivotal role of the faecal microbiome in cirrhosis

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