Effect of probiotic mix (<i>Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus</i>) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trial

Kim, Ji Yeun; Kwon, Jung Hyun; Ahn, So Hyun; Lee, Sang Il; Han, Young Ho; Choi, Young-Hyun; Lee, Soo Young; Ahn, Kyunghan; Ji, Geun Eog

doi:10.1111/j.1399-3038.2009.00958.x

Cited by 238 publications

(184 citation statements)

References 27 publications

(29 reference statements)

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“…No difference in food allergen sensitization (measured by serum specific IgE (sIgE)) was observed between active and placebo group at 1 and 2 years of age. This lack of effect on FA prevention was also observed by Kim et al [79] in a RDBPC trial using a combination of three probiotics (Bifidobacterium bifidum, B. lactis and Lactobacillus acidophilus) starting at 4-8 weeks before delivery and continuing for 6 months. The same results were also reported with a probiotic mixture of three strains (Lactobacillus rhamnosus GG, L. acidophilus and Bifidobacterium animalis) given to a nonselected maternal population [80].…”

supporting

confidence: 68%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

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supporting

confidence: 68%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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“…early, late and prolonged formula feeding; exclusively breastfed, mixed breastfed or exclusively formula-fed; and high or normal risk for allergic disease) which makes it difficult to perform meta-analyses in such populations. Trials of prebiotic and probiotic interventions also suffered from large heterogeneity in the interventions and it should be noted that several probiotic trials have been published since the last systematic review on this subject, [62][63][64][65][66][67][68][69][70] warranting an updated review.…”

Section: Quality Of the Evidencementioning

confidence: 99%

“…The strength of some conclusions was limited by small numbers of trials or participants included in the relevant reviews and the analysis of probiotic effects was limited by the recent publication of many relevant trials [62][63][64][65][66][67][68][69][70] that have not yet been incorporated into a Cochrane systematic review. A more recent meta-analysis incorporating many of these trials 71 found that probiotic supplementation significantly reduces risk of developing eczema in infancy (RR 0.79, 95% CI 0.67 to 0.92), a finding supported by subsequent reviews.…”

Section: Limitationsmentioning

confidence: 99%

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Kim

Batchelor

Bath‐Hextall

et al. 2016

Programme Grants Appl Res

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Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10177. The contractual start date was in September 2008. The final report began editorial review in April 2014 and was accepted for publication in April 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, ...

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“…Despite uncertainties regarding their efficacy, infant formulae are increasingly supplemented with probiotics, prebiotics or synbiotics (1) . Some trials show favourable results for probiotics with regard to atopic dermatitis and it was reported that prenatal and postnatal probiotic supplementation is an effective approach in preventing the development of eczema during 1 year of life in infants at high risk of allergy (30,45) . A pioneering placebo-controlled study in high-risk families with perinatal supplementation of the mothers' and infants' diet with Lactobacillus GG demonstrated a reduced prevalence of early atopic dermatitis in children (46) .…”

Section: The Role Of Probiotics and Prebioticsmentioning

confidence: 99%

Infant nutrition and allergy

Mišak

2011

Proc. Nutr. Soc.

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Over the past several decades, the incidence of atopic diseases such as asthma, atopic dermatitis and food allergies has increased dramatically. Although atopic diseases have a clear genetic basis, environmental factors, including early infant nutrition, may have an important influence on their development. Therefore, attempts have been made to reduce the risk of the development of allergy using dietary modifications, mainly focused on longer breast-feeding and delayed introduction or elimination of foods identified as potentially most allergenic. Recently, there is also an increasing interest in the active prevention of atopy using specific dietary components. Many studies have shown that breast-feeding may have the protective effect against future atopic dermatitis and early childhood wheezing. Concerning complementary feeding, there is evidence that the introduction of complementary foods before 4 months of age may increase the risk for atopic dermatitis. However, there is no current convincing evidence that delaying introduction of solids after 6 months of age has a significant protective effect on the development of atopic disease regardless of whether infants are fed cow's milk protein formula or human subject's milk, and this includes delaying the introduction of foods that are considered to be highly allergic, such as fish, eggs and foods containing peanut protein. In conclusion, as early nutrition may have profound implications for long-term health and atopy later in life, it presents an opportunity to prevent or delay the onset of atopic diseases.

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Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trial

Cited by 238 publications

References 27 publications

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Infant nutrition and allergy

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