Effect of Probiotic Lactobacillus salivarius on Peri-Implantitis Pathogenic Bacteria: An In Vitro Study

Mulla, Munaz; Hegde, Shashikanth; Koshy, Ajit V.; Mulla, Mushir

doi:10.7759/cureus.20808

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…In our study, the strong bacteriostatic activity of L. salivarius supernatant and L. agilis supernatant were verified. In agreement, L. salivarius and L. agilis 32 were previously proved to present an excellent antibacterial effect on pathogenic bacterium of humans or chickens ( 25 , 30 ). These implied that the stimulation from gut flora to ISCs was alleviated after feeding L. salivarius or L. agilis .…”

Section: Discussionsupporting

confidence: 62%

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

Zhou

Cao

et al. 2022

mSystems

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Section: Discussionsupporting

confidence: 62%

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

Zhou

Cao

et al. 2022

mSystems

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Section: Discussionmentioning

confidence: 99%

“…On the probiotic side, Lactobacillus reuteri is one of the most studied probiotics for potential peri-implantitis treatment [ 22 ]. The probiotic has antagonistic effects on peri-implantitis pathogens [ 22 ], yet, recent metadata analyses demonstrated that the bacterium provides limited benefits to patients with peri-implant mucositis or peri-implantitis [ 55 , 56 ]. For instance, Peña et al [ 57 ] tested the use of L. reuteri after mechanical debridement and the use of a0.12% chlorhexidine mouthwash in 50 patients with peri-implant mucositis.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review on peri-implantitis found similar microbial pathogens in peri-implantitis and periodontitis lesions, including Tannarella forsythia , Porphyromonas gingivalis , several Fusobacterium species, including Fusobacterium nucleatum , Prevotella intermedia , Prevotella nigrescens and Aggregatibacter actinomycetemcomitans [ 19 ]. Others report that the microbial composition of peri-implantitis is more complex and that there is a distinct microbiological profile from periodontitis, which includes higher Treponema denticola , Staphylococci , Peptostreptococci , Streptococci , enterics, and several yeasts species [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting

et al. 2022

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Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar to periodontal disease, oral dysbiosis is thought to be a driver of peri-implantitis. However, managing peri-implantitis with traditional treatment methods, such as nonsurgical debridement or surgery, is not always successful. Thus, novel strategies have been proposed to address these shortcomings. One strategy is the use of probiotics as antimicrobial agents since they are considered safe for humans and the environment. Specifically, the probiotic Lactococcus lactis produces nisin, which has been used worldwide for food preservation. The objective of this study was to determine whether nisin and the wild-type (WT) nisin-producing L. lactis probiotic can disrupt oral pathogenic biofilms and promote a healthier oral microbiome within these oral biofilms on titanium discs. Using confocal imaging and 16S rRNA sequencing, this study revealed that nisin and WT L. lactis probiotic disrupt oral pathogenic biofilms in a peri-implantitis setting in vitro. More specifically, nisin decreased the viability of the pathogen-spiked biofilms dose-dependently from 62.53 ± 3.69% to 54.26 ± 3.35% and 44.88 ± 2.98%, respectively. Similarly, 105 CFU/mL of WT L. lactis significantly decreased biofilm viability to 52.45 ± 3.41%. Further, both treatments shift the composition, relative abundance, and diversity levels of these biofilms towards healthy control levels. A total of 1 µg/mL of nisin and 103 CFU/mL of WT L. lactis were able to revert the pathogen-mediated changes in the Proteobacteria (from 80.5 ± 2.9% to 75.6 ± 2.0%, 78.0 ± 2.8%, and 75.1 ± 5.3%, respectively) and Firmicutes (from 11.6 ± 1.6% to 15.4 ± 1.3%, 13.8 ± 1.8%, and 13.7 ± 2.6%, respectively) phyla back towards control levels. Thus, nisin and its nisin-producing L. lactis probiotic may be useful in treating peri-implantitis by promoting healthier oral biofilms, which may be useful for improving patient oral health.

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“…Streptococci also inhibit the first two by producing organic acids, especially lactate [ 105 ]. Aggregatibacter actinomycetemcomitans was resistant at all probiotic concentrations used in the study [ 115 ]. Fortunately, it can be inhibited by Lactobacillus bulgaricus [ 116 ].…”

Section: Oral Microbiota Modulation In Valvular Heart Disease–current...mentioning

confidence: 99%

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

Neculae

Gosav

Valasciuc

et al. 2023

Life

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Oral microbiota formation begins from birth, and everything from genetic components to the environment, alongside the host’s behavior (such as diet, smoking, oral hygiene, and even physical activity), contributes to oral microbiota structure. Even though recent studies have focused on the gut microbiota’s role in systemic diseases, the oral microbiome represents the second largest community of microorganisms, making it a new promising therapeutic target. Periodontitis and dental caries are considered the two main consequences of oral bacterial imbalance. Studies have shown that oral dysbiosis effects are not limited locally. Due to technological advancement, research identified oral bacterial species in heart valves. This evidence links oral dysbiosis with the development of valvular heart disease (VHD). This review focuses on describing the mechanism behind prolonged local inflammation and dysbiosis, that can induce bacteriemia by direct or immune-mediated mechanisms and finally VHD. Additionally, we highlight emerging therapies based on controlling oral dysbiosis, periodontal disease, and inflammation with immunological and systemic effects, that exert beneficial effects in VHD management.

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Effect of Probiotic Lactobacillus salivarius on Peri-Implantitis Pathogenic Bacteria: An In Vitro Study

Cited by 8 publications

References 21 publications

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

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