Effect of Probiotic Lactobacillus reuteri on Salivary Cariogenic Bacterial Counts among Groups of Preschool Children in Jeddah, Saudi Arabia: A Randomized Clinical Trial

Alamoudi, Najlaa M.; Almabadi, Eman S; Ashiry, Eman A El; Derwi, Douaa A. El

doi:10.17796/1053-4625-42.5.2

Cited by 21 publications

(14 citation statements)

References 24 publications

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“…Lactobacillus rhamnosus GG (ATCC 53103) [20][21][22][23], hct 70 [24], LB21 [25], LC 705 [22] reuteri ATCC 55,730 (SD2112) [26][27][28], ATCC PTA 5289 [29][30][31][32], DSM 17,938 [29][30][31][32] casei Shirota [33] paracasei F19 [34], GMNL-33 [35], SD1 [36][37][38] achidophilus ATCC 4356 [39], La-5 [40] salivarius TI 2711 [41], WB21 [41] brevis CD2 [42] bifidum [43] bulgaricus [43] sporogens [43] thermophilus [43] Bifidobacterium animalis lactis BB-12 (ATCC 27536) [40,[44][45][46], DN-173010 [47,48] bifidum ATCC 29,521 [39] longum [49] Streptococci mutans A2JM [50] rattus JH145 TM [51,52] oralis KJ3 TM [52] uberis KJ2 TM [52] dentisani CECT7746…”

Section: Genus Species Strainmentioning

confidence: 99%

“…It is worth mentioning that although a significant reduction in caries incidence was reported, no caries-associated microbiological alterations were observed. Other strains of L. reuteri (DSM 17,938 and ATCC PTA 5289), when administered through lozenges twice a day, prevail against MS and Lactobacilli and benefit the salivary buffer capacity [32].…”

Section: Clinical Considerations On Probiotics' Effectivenessmentioning

confidence: 99%

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Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

et al. 2021

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Probiotic therapy forms a new strategy for dental caries prevention. Probiotic microorganisms possess the ability to displace cariogenic microorganisms and colonize the oral cavity. They can produce various antimicrobial substances such as bacteriocins, bacteriocin-like peptides, lactic acid, and hydrogen peroxide. Dairy products may be ideal for probiotic administration in dental patients. Many other means have been proposed, primarily for those allergic to dairy components, such as capsules, liquid form, tablets, drops, lozenges, sweetened cakes, and ice creams. The last two forms can be used in a coaching approach for children and elderly patients who find it difficult to avoid sugary beverages in their daily routine and benefit from the suggestion of easy, cheap, and common forms of delicacies. In caries prevention, the concept of the effector strain is already considered an integral part of the contemporary caries cure or prevention strategy in adults. Adults, though, seem not to be favored as much as children at early ages by using probiotics primarily due to their oral microbiome’s stability. In this non-systematic review we describe the modes of action of probiotics, their use in the cariology field, their clinical potential, and propose options to prevent caries through a patient coaching approach for the daily dental practice.

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Section: Genus Species Strainmentioning

confidence: 99%

Section: Clinical Considerations On Probiotics' Effectivenessmentioning

confidence: 99%

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

et al. 2021

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“…Tablet consumption of L. reuteri DSM 17938 and ATCC PTA 5289 for 28 days also caused a significant reduction in salivary S. mutans and Lactobacillus spp. counts in children [84]. In contrast, L. paracasei F19 given as a dietary supplement for 9 months had no significant effect at the microbiological and clinical levels at 3, 6 and 9 years of age [74].…”

Section: Probiotics In Cariologymentioning

confidence: 82%

Probiotics in Oral Health and Disease: A Systematic Review

Saïz¹,

Taveira²,

Alves³

2021

Applied Sciences

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Purpose: Probiotics may exclude or antagonize oral pathogens and be useful to prevent oral dysbiosis and treat oral diseases. The objective of this review was to assess the benefits of probiotics in oral health and disease, and in dental practice; Methods: Primary articles published between January 2012 and 30 December 2020 with full text available were searched in PubMed, ClinicalTrials.gov, ScienceDirect, Google Scholar, B-on, and SciELO; Results: The electronic search identified 361 references of which 91 (25.2%) met all the inclusion criteria. In total, data from 5374 participants with gingivitis, periodontitis, peri-implantitis, caries, orthodontic conditions, halitosis, or oral conditions associated with chemo-radiotherapy were included. Despite major inconsistencies between clinical trials, probiotics have been found to contribute to reduce S. mutans counts (L. paracasei SD1), reduce probing depth in chronic periodontitis (B. animalis subsp. lactis DN-173010 with L. reuteri), reduce levels of volatile sulfur compounds and halitosis (L. salivarius WB21), treat oral mucositis and improve the quality of life of patients undergoing cancer chemo-radiotherapy (L. brevis CD2). Combinations of probiotic bacteria tend to lead to higher clinical efficacy than any individual probiotic agent; Conclusion: Oral probiotics influence favorably the oral microbiota and provide benefits to the oral ecosystem in periodontal diseases, cariology, halitosis, orthodontics and management of oral mucositis resulting from cancer treatment. However, the use of probiotics in dental practice or in self-management preventive strategies requires additional well controlled clinical trials to determine the most effective probiotic combinations, the most appropriate probiotic vehicle, and the frequency of administration.

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“…377 A second randomized trial investigated the use of probiotic lozenges containing L. reuteri, one of the most investigated probiotic anticaries agents. 378 Heathy 3-to 6-year-old (N=178) children were randomly divided into 2 groups. The control group received placebo lozenges twice daily for 28 days, while the experimental group received L. reuteri probiotic lozenges.…”

Section: Dental Caries and Cariologymentioning

confidence: 99%

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna

Donovan

McKee³

et al. 2019

The Journal of Prosthetic Dentistry

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Effect of Probiotic Lactobacillus reuteri on Salivary Cariogenic Bacterial Counts among Groups of Preschool Children in Jeddah, Saudi Arabia: A Randomized Clinical Trial

Abstract: Consumption of probiotic lozenges containing L. reuteri reduces caries-associated bacterial counts significantly. Probiotics consumption may have a beneficial caries-preventive effect.

Cited by 21 publications

References 24 publications

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

Probiotics, Prebiotics, Synbiotics and Dental Caries. New Perspectives, Suggestions, and Patient Coaching Approach for a Cavity-Free Mouth

Probiotics in Oral Health and Disease: A Systematic Review

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

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