Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and zinc status of Indonesian pre-school children

Surono, Ingrid S.; Martono, Pratiwi D.; Kameo, Satomi; Suradji, Eka W.; Koyama, Hiroshi

doi:10.1016/j.jtemb.2014.07.009

Cited by 50 publications

(55 citation statements)

References 19 publications

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“…Two potential probiotics originating from dadih have gone through a clinical study in humans [69,70]. Surono et al [69] evaluated the effect of E. faecium IS-27526 in milk on humoral immune response and on bodyweight of young children aged between 15 and 54 months.…”

Section: Human Studiesmentioning

confidence: 99%

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A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

Nuraida

2015

Food Science and Human Wellness

162

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Traditional Indonesian fermented foods can be used as potential sources of probiotics as they commonly contain lactic acid bacteria (LAB), including species of Lactobacillus, Pediococcus, Enterococcus, Weisella and Leuconostoc. The occurrence of LAB in Indonesian fermented foods is not only limited to lactic fermented foods but is also present in foods with molds as the main starter culture. This review aims to describe the significance of Indonesian fermented foods as potential sources of probiotics and the potential of LAB from fermented foods to promote beneficial health effects. A number of in vitro studies have been carried out to assess the probiotic potential of LAB from fermented foods. Many LAB strains have met the basic requirements for them to be considered as probiotics and possess some functional properties contributing to positive health impacts. Hypocholesterolemic effects, stimulation of the immune system, and prevention of diarrhea by some probiotic strains have been shown in animal studies. However, human studies on the efficacy of probiotic strains are still limited. Two strains isolated from dadih, a fermented buffalo milk, are examples of promising probiotic strains that have gone through human studies. The potential probiotic properties of LAB in Indonesian fermented foods still need to be fully investigated to assess their impact on human health. The studies should also consider factors that may influence the functional properties of probiotics, both in foods and in humans.

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Section: Human Studiesmentioning

confidence: 99%

“…Another human study [70] evaluated the effect of probiotic L. plantarum IS-10506 (originally isolated from dadih) and zinc supplementation on humoral immune response and zinc status of Indonesian infants aged 12-24 months in a 90-day randomized, double-blind, placebo-controlled trial. A combination of microencapsulated Lb.…”

Section: Human Studiesmentioning

confidence: 99%

A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

Nuraida

2015

Food Science and Human Wellness

162

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“…We found 23 studies [36,43,48,59,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88], with 35 comparisons, 14 of them comparing zinc alone to placebo, 17 of them comparing zinc in combination with iron to iron only and four of them comparing zinc and other micronutrients to other micronutrients. Sub-group analyses showed that if iron was part of the intervention, the effect of zinc on serum/plasma zinc concentrations was considerably lower (1.02 µmol/L, 95% CI 0.28, 1.76), compared to interventions delivering zinc alone (3.04 µmol/L, 95% CI 1.16, 4.92) and to interventions delivering zinc and other micronutrients, excluding iron (2.77 µmol/L, 95% CI 0.13, 5.42; Figure 2).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Low Dose Iron and Zinc Intake on Child Micronutrient Status and Development during the First 1000 Days of Life: A Systematic Review and Meta-Analysis

Petry¹,

Olofin²,

Boy

et al. 2016

Nutrients

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Adequate supply of micronutrients during the first 1000 days is essential for normal development and healthy life. We aimed to investigate if interventions administering dietary doses up to the recommended nutrient intake (RNI) of iron and zinc within the window from conception to age 2 years have the potential to influence nutritional status and development of children. To address this objective, a systematic review and meta-analysis of randomized and quasi-randomized fortification, biofortification, and supplementation trials in women (pregnant and lactating) and children (6–23 months) delivering iron or zinc in doses up to the recommended nutrient intake (RNI) levels was conducted. Supplying iron or zinc during pregnancy had no effects on birth outcomes. There were limited or no data on the effects of iron/zinc during pregnancy and lactation on child iron/zinc status, growth, morbidity, and psychomotor and mental development. Delivering up to 15 mg iron/day during infancy increased mean hemoglobin by 4 g/L (p < 0.001) and mean serum ferritin concentration by 17.6 µg/L (p < 0.001) and reduced the risk for anemia by 41% (p < 0.001), iron deficiency by 78% (ID; p < 0.001) and iron deficiency anemia by 80% (IDA; p < 0.001), but had no effect on growth or psychomotor development. Providing up to 10 mg of additional zinc during infancy increased plasma zinc concentration by 2.03 µmol/L (p < 0.001) and reduced the risk of zinc deficiency by 47% (p < 0.001). Further, we observed positive effects on child weight for age z-score (WAZ) (p < 0.05), weight for height z-score (WHZ) (p < 0.05), but not on height for age z-score (HAZ) or the risk for stunting, wasting, and underweight. There are no studies covering the full 1000 days window and the effects of iron and zinc delivered during pregnancy and lactation on child outcomes are ambiguous, but low dose daily iron and zinc use during 6–23 months of age has a positive effect on child iron and zinc status.

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“…The L. plantarum IS‐10506 has been shown to enhance humoural immune response, faecal sIgA and improve zinc status of children younger than 2 years of age (Surono et al . ), and as a potential treatment in Atopic Dermatitis in children (Prakoeswa et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…) and in human studies have demonstrated enhancement of humoural immune response, and nutrient absorption in several studies (Surono et al . , ).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation increases survival of the probioticLactobacillus plantarumIS-10506, but notEnterococcus faeciumIS-27526 in a dynamic, computer-controlledin vitromodel of the upper gastrointestinal tract

Surono

Verhoeven²,

Verbruggen³

et al. 2018

J Appl Microbiol

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Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and zinc status of Indonesian pre-school children

Cited by 50 publications

References 19 publications

A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

The Effect of Low Dose Iron and Zinc Intake on Child Micronutrient Status and Development during the First 1000 Days of Life: A Systematic Review and Meta-Analysis

Microencapsulation increases survival of the probioticLactobacillus plantarumIS-10506, but notEnterococcus faeciumIS-27526 in a dynamic, computer-controlledin vitromodel of the upper gastrointestinal tract

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