Effect of Probe Ultrasonication, Microwave and Sunlight on Biosynthesis, Bioactivity and Structural Morphology of Punica granatum Peel’s Polyphenols-Based Silver Nanoconjugates

Foujdar, Rimpi; Chopra, Harish Kumar; Bera, Manab Bandhu; Chauhan, Anil Kumar; Mahajan, Palak

doi:10.1007/s12649-020-01175-2

Cited by 11 publications

(10 citation statements)

References 70 publications

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“… 164 Nanoparticles have been previously proven to improve the bioavailability of the material. 165 , 166 However, even though these nanosized particles have better bioavailability, the mechanism and function of produced ferritin mimetic nanoparticles are unclear. 15 Besides their positive effects, oral nanoparticles causing adverse effects are still a concern, especially for their application in the food industry.…”

Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 99%

“…Nanotechnology is emerging as a viable technique for effective iron food fortification and drug delivery for the treatment of anemia, and food technologists and researchers are increasingly active in using it . Nanoparticles have been previously proven to improve the bioavailability of the material. , However, even though these nanosized particles have better bioavailability, the mechanism and function of produced ferritin mimetic nanoparticles are unclear . Besides their positive effects, oral nanoparticles causing adverse effects are still a concern, especially for their application in the food industry .…”

Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 99%

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Iron Absorption: Factors, Limitations, and Improvement Methods

et al. 2022

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Iron is an essential element for human life since it participates in many functions in the human body, including oxygen transport, immunity, cell division and differentiation, and energy metabolism. Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods. The average daily dietary iron intake is 10 to 15 mg in humans since only 1 to 2 mg is absorbed through the intestinal system. Nutrient–nutrient interactions may play a role in dietary intestinal iron absorption. Dietary inhibitors such as calcium, phytates, polyphenols and enhancers such as ascorbic acid and proteins mainly influence iron bioavailability. Numerous studies have been carried out for years to enhance iron bioavailability and combat iron deficiency. In addition to traditional methods, innovative techniques are being developed day by day to enhance iron bioavailability. This review will provide information about iron bioavailability, factors affecting absorption, iron deficiency, and recent studies on improving iron bioavailability.

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Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 99%

Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 99%

Iron Absorption: Factors, Limitations, and Improvement Methods

et al. 2022

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“…Among many nanotechnology applications, one is to increase nutrient bioavailability and delivery of minerals, nutrients, molecules, and drugs to their target. Researchers found that when some of the materials are prepared in nanometer size, their bioavailability increases (Shafie et al 2016 ; Foujdar et al 2020 ). For these details, food technologists and researchers are now involved in employing nanotechnology, which is emergent as a promising strategy for the efficient iron food fortification and delivery of drugs for the treatment of anemia.…”

Section: Nanotechnology For Iron Deficiency Anemiamentioning

confidence: 99%

Iron nanoparticles as a promising compound for food fortification in iron deficiency anemia: a review

Kumari

Chauhan

2021

J Food Sci Technol

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Iron deficiency anemia (IDA) is a global health concern that is affecting all age groups significantly. Among many of the existing methods, the fortification of foods with iron salts is the best and most cost-effective strategy for targeting large-scale populations to provide nutritional security. The fortification of foods with iron salts is a challenging task because most iron complexes (ferrous sulfate, ferrous chloride) used in fortification are highly water-soluble, which impart unacceptable organoleptic changes in food vehicles and also causes gastrointestinal problems. However, insoluble iron salts (ferric pyrophosphate) do not cause unacceptable taste or color in food vehicles but low bioavailable. Nanosized iron salts can overcome these concerns. The particle size of iron salts has been reported to play an important role in the absorption of iron. Reduction in the particle size of iron compounds increases its surface area, which in turn improves its solubility in the gastric juice leading to higher absorption. Nanosized iron compound produces minimal organoleptic changes in food vehicles compared to water-soluble iron complexes. Thus nanosized iron salts find potential applications in food fortification to reduce IDA. This paper focuses on providing a complete review of the various iron salts used in IDA, including their bioavailability, the challenges to food fortification, the effects of nanosized iron salts on IDA, and their applications in food fortification. Graphic abstract Fortification of foods with water-soluble Fe salts imparts unacceptable organoleptic changes in food vehicle and adverse impact on health. However, insoluble iron salts do not cause unacceptable taste or color in food vehicles but low bioavailable. Using Nano-sized iron compound produces minimal organoleptic changes in food vehicles compared to changes produced by water-soluble iron complexes, improves Fe absorption in the gastrointestinal tract and does not cause any health issues.

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“…(20) Plant extracts contain various phytoconstituents which possess various functional groups, (21) which act as reducing agents without the addition of synthetic chemicals to produce stable nanoparticles or nanoconjugates (22). The conjugation of plant polyphenols with metal nanoparticles exhibits the advantageous properties of both materials (23). Additionally to working as a reducing and capping agent during the formation of metallic nanoparticles, polyphenols also increase the biological activity of nanoparticles, whereas conjugated silver nanoparticles (AgNCs) increase polyphenol stability in extreme situations (such as heat, light, etc.…”

Section: Introductionmentioning

confidence: 99%

Invitro efficacy of green synthesized silver nanoconjugates of Valeriana wallichii methanolic root extract against MDR strain of Acinetobacter baumannii

Kumar

Agarwal

Anguluri

et al. 2023

Preprint

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Background Antimicrobial resistance is peaking up all over the world and requires immediate attention. In quest of finding a sustainable solution to the present threat of future epidemics which is going to be caused by Acinetobacter baumannii (A. baumannii) as per the WHO report (2020), this study has been used to pave a path for finding an herbal solution to it. The novelty of this study is that Valeriana wallichii (V. wallichii) has been analyzed for its methanolic extract/nano-conjugate against A baumannii. Results HPLC of the extract has shown the presence of polyphenols- Quercitin, Rutin, and Tannic acid in high concentration. This fraction on nano-conjugation with silver has shown its equivalence to tetracycline antibiotics in restricting the growth of A. baumannii. Further, insilico studies taking crucial death receptors (Amp C, Fab1, RstA, LpxA, Aspartokinase, and shikimate dehydrogenase) of A. baumannii have shown binding energy ranging from − 11.6 to -13.3 kcal/mol for Tannic acid and close to this for Rutin and Linalool. It signifies that the fraction is potent enough to be a potential drug candidate for restricting this bacterium. The results were amazing when V. wallichii silver nanoconjugate (Vw-AgNCs), size range 1-200nm validated by DLS, AFM, and SEM-EDX on green synthesis has many times substantially enhanced restriction of A. baumannii as compared to only extract of V. wallichii. Keeping in view, its application to mankind, the cytotoxicity of the extract was evaluated on the human Fibroblast cell line (L929), showing an LC50 value of 368ug/ml. Many types of research have shown the time-dependent cytotoxicity of antibiotics as low as 5-50ug/ml providing us with a huge therapeutic window for the Vw-AgNCs. Conclusion Vw-AgNCs exhibited strong antimicrobial activity than the only extract and chemically synthesized nanoparticles so they can be a potential antimicrobial agent against A. baumannii in the future.

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Effect of Probe Ultrasonication, Microwave and Sunlight on Biosynthesis, Bioactivity and Structural Morphology of Punica granatum Peel’s Polyphenols-Based Silver Nanoconjugates

Cited by 11 publications

References 70 publications

Iron Absorption: Factors, Limitations, and Improvement Methods

Iron Absorption: Factors, Limitations, and Improvement Methods

Iron nanoparticles as a promising compound for food fortification in iron deficiency anemia: a review

Invitro efficacy of green synthesized silver nanoconjugates of Valeriana wallichii methanolic root extract against MDR strain of Acinetobacter baumannii

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