Effect of primary treatment on survival in anaplastic thyroid carcinoma

Bešič, Nikola; Auersperg, M.; Us‐Krašovec, Marija; Golouh, Rastko; Frković‐Grazio, Snjez̆ana; Vodnik, Alenka Cerar

doi:10.1053/ejso.2000.1098

Cited by 109 publications

(87 citation statements)

References 13 publications

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“…Regarding undifferentiated carcinoma, previous studies have indicated that its prognosis is usually dire, although favorable outcomes can occasionally be expected in cases with curative surgery together with chemotherapy and/or radiotherapy [28, 29]. Our results indicate the difficulty of predicting the prognosis of such cases by investigating RCAS1 expression.…”

Section: Discussionmentioning

confidence: 67%

Overexpression of Human Tumor-Associated Antigen, RCAS1, Is Significantly Linked to Dedifferentiation of Thyroid Carcinoma

et al. 2002

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Objective: Counterattack by RCAS1 on carcinoma to cytotoxic T cells and natural killer (NK) cells has been suggested as a contribution to carcinoma progression, because RCAS1 can inhibit their proliferation and induce apoptosis. In this study, we examined RCAS1 expression in various thyroid neoplasms in order to clarify its clinical significance. Methods: We studied RCAS1 expression by means of immunohistochemistry using a mouse monoclonal antibody against RCAS1 for normal thyroid epithelium, follicular adenoma, follicular carcinoma, papillary carcinoma and undifferentiated (anaplastic) carcinoma. Results: Normal epithelium and follicular adenoma did not express or only faintly expressed RCAS1. In thyroid carcinomas. RCAS1 overexpression was more frequently observed in anaplastic (undifferentiated) carcinomas than papillary (p < 0.0001) and follicular carcinomas (p = 0.0018). In follicular carcinoma, the widely invasive type more frequently overexpressed RCAS1 than the minimally invasive type (p = 0.0488). Furthermore, the incidences of RCAS1 overexpression increased with carcinoma dedifferentiation (p < 0.0001). Conclusion: These results suggest that RCAS1 may contribute to the progression of thyroid carcinoma with high biological aggressiveness.

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Section: Discussionmentioning

confidence: 67%

Overexpression of Human Tumor-Associated Antigen, RCAS1, Is Significantly Linked to Dedifferentiation of Thyroid Carcinoma

et al. 2002

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“…The evidence that supports such an approach, however, is based on single-institution studies of select groups of patients. 5,7,9,10,13,16,[22][23][24][25][26] Our current study of the population-based SEER data demonstrates that patients Ͻ 60 years old who have intrathyroidal ATC have a better prognosis compared with older patients who have distant metastasis. Surgical resection with external beam radiation in patients with regional and distant ATC was associated with lower cause-specific cancer mortality.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic thyroid carcinoma

Kebebew

Greenspan

Clark

et al. 2005

Cancer

531

183

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BACKGROUNDAnaplastic thyroid carcinoma (ATC) is rare but is one of the most aggressive human malignancies. Several prognostic factors have been observed in patients with ATC, and some experts advocate aggressive multimodal therapy in selected patients. However, it is unclear whether such an approach significantly improves survival. The authors analyzed prognostic factors and treatment outcomes in patients with ATC reported in the National Cancer Institute's Surveillance, Epidemiology, and End Results data base.METHODSThe cohort consisted of 516 patients with ATC reported to 12 population‐based cancer registries between 1973 and 2000. Demographic, pathologic, and treatment data were used for univariate and multivariate survival analyses.RESULTSThe mean patient age at diagnosis was 71.3 years, and there were 171 men and 345 women. Eight percent of patients had intrathyroidal tumors, 38% had extrathyroidal tumors and/or lymph node invasion, and 43% of patients had distant metastasis. The average tumor size was 6.4 cm (range, 1–15 cm). Sixty‐four percent of patients underwent surgical resection of their primary tumor, and 63% received external beam radiotherapy. The overall cause‐specific mortality rate was 68.4% at 6 months and 80.7% at 12 months. Univariate analysis showed that age < 60 years, female gender, intrathyroidal tumor, external beam radiotherapy, surgical resection, and combined surgical resection of tumor and radiotherapy were associated with a lower cause‐specific mortality. On multivariate analysis, only age < 60 years, an intrathyroidal tumor, and the combined use of surgical and external beam radiation therapy were identified as independent predictors of lower cause‐specific mortality.CONCLUSIONSAlthough most patients with ATC had an extremely poor prognosis, patients < 60 years old with intrathyroidal tumors survived longer. Surgical resection with external beam radiotherapy for ATC was associated with lower cause‐specific mortality. Cancer 2005. © 2005 American Cancer Society.

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“…78,82 A recent study suggested that primary chemoradiation followed by surgery had a positive impact on short-term survival. 101 Despite the variable sequence of treatment, multimodality regimens currently offer the best hope for patients with ATC. Fig 4 represents our management of patients with ATC.…”

Section: Surgerymentioning

confidence: 99%

Poorly Differentiated and Anaplastic Thyroid Cancer

2006

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Background: Poorly differentiated thyroid carcinoma (PDTC) and anaplastic (undifferentiated) thyroid carcinoma (ATC) comprise a small subset of thyroid tumors that are associated with a poor prognosis and account for Shaha, MD, FACS, Head and Neck Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021. E-mail: shahaa@mskcc.org No significant relationship exists between the authors and the companies/organizations whose products or services may be referenced in this article. Abbreviations used in this paper: PDTC = poorly differentiated thyroid carcinoma, WDTC = well-differentiated thyroid carcinoma, ATC = anaplastic thyroid carcinoma, ITC = insular thyroid carcinoma, FNAB = fine-needle aspiration biopsy, TG = thyroglobulin, RAI = radioactive iodine, EBRT = external-beam radiation therapy.

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Effect of primary treatment on survival in anaplastic thyroid carcinoma

Cited by 109 publications

References 13 publications

Overexpression of Human Tumor-Associated Antigen, RCAS1, Is Significantly Linked to Dedifferentiation of Thyroid Carcinoma

Overexpression of Human Tumor-Associated Antigen, RCAS1, Is Significantly Linked to Dedifferentiation of Thyroid Carcinoma

Anaplastic thyroid carcinoma

Poorly Differentiated and Anaplastic Thyroid Cancer

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