Effect of pretreatment with statins on the severity of acute ischemic cerebrovascular events

Serum Lipids and Statin Treatment During Acute Stroke

“…He found a good outcome (defined as mRS score >2) in 52% in the statin protected group, compared with 38% among controls (p=0.02). At the same time, Greisenegger et al [2004] confirmed the findings with a cross-sectional study of 1,691 patients. They found also, that among the diabetes mellitus patients, the percentage of bad outcome (defined as mRS score of 5-6) was 16% of the untreated patient group, whereas no bad outcome was found among the statin treated group.…”

Association of Serum Bilirubin with Ischemic Stroke Outcomes

“…To evaluate the role of possible confounding factors, other potential determinants of incident stroke severity were also analyzed based on prior reports in the literature: age, sex, history of atrial fibrillation, history of hypertension, hyperlipidemia, diabetes, smoking status, admission glucose, premorbid antithrombotic use, premorbid statin use, and premorbid functional status. [12][13][14][15][16][17] Potential baseline covariate predictors of functional status at hospital discharge included all the aforementioned potential determinants of stroke severity and admission NIHSS score. 12 The pool of potential covariates (listed above) were then selected using backward elimination at P =.2.…”

Statins and Stroke

“…An earlier, retrospective pilot case-referent study investigated the influence of statin pretreatment on stroke outcome but the results-albeit in favor of a benefit-were not significant (Jonsson and Asplund, 2001). Greisenegger et al (2004) describe in a cross-sectional study within a prospective cohort of ischemic stroke patients that statin use is negatively associated with stroke severity: of 1,691 patients, 152 were taking statins. Patients with a modified Rankin score of 5 or 6 (which corresponds to severe disability or death) at 1 week after stroke were significantly less frequent in the statin group (Greisenegger et al, 2004).…”

“…Greisenegger et al (2004) describe in a cross-sectional study within a prospective cohort of ischemic stroke patients that statin use is negatively associated with stroke severity: of 1,691 patients, 152 were taking statins. Patients with a modified Rankin score of 5 or 6 (which corresponds to severe disability or death) at 1 week after stroke were significantly less frequent in the statin group (Greisenegger et al, 2004). Of note, particularly patients with diabetes benefitted from statin use.…”