Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin

Dayal, Monika; Parmar, Devendra; Dhawan, Alok; Ali, M. M.; Dwivedi, U N; Seth, Prahlad K.

doi:10.1016/s0278-6915(02)00249-1

Cited by 37 publications

(14 citation statements)

References 26 publications

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“…(Song and Narahashi, 1996;Dayal et al, 2003;Kale et al, 1999). Our previous studies indicated that oxidative damage induced by permethrin treatment in adult rats involving DNA damage in lymphocytes, cellular damage in erythrocytes, impaired phagocytosis of monocytes and in the neonatal rats behaviour changes, alterations of striatal monoamine levels, striatal protein oxidation were observed (Cantalamessa, 1993;Gabbianelli et al, 2002;Nasuti et al, 2003Nasuti et al, , 2007.…”

Section: Introductionmentioning

confidence: 97%

Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

et al. 2008

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Section: Introductionmentioning

confidence: 97%

Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

et al. 2008

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“…An age-dependent effect was observed, indicating that neonatal rats are 4-17 times more vulnerable to the acute toxicity of pyrethroids than adult rats (Cantalamessa, 1993;Sheets et al, 1994). Although mammals are three orders of magnitude less sensitive at ion channel sites than insects to pyrethoids, recent studies show that these insecticides can induce oxidative damage not only in the brain but also in other targets such as liver, erythrocytes and lymphocytes (Song and Narahashi 1996;Vais et al, 2000;Dayal et al, 2003;Gabbianelli et al, 2002Gabbianelli et al, , 2004Nasuti et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats

Gabbianelli

Falcioni

Cantalamessa

et al. 2009

J of Applied Toxicology

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Pyrethroids are widely used insecticides of low acute toxicity in mammals but the consequences of long-term exposure are of concern. Their insecticidal action is related to neurotoxicity and, in addition, there are indications of mammalian immuno-toxicity. In this work the effect of 60 days permethrin (150 mg kg(-1) body weight/day) exposure on two types of leukocytes (monocytes and lymphocytes) in adolescent rats was investigated. In particular, the monocyte respiratory burst response was first investigated, followed by studies on the degree and type of lymphocyte DNA damage induced by permethrin at this stage of life. Permethrin treatment reduces the monocyte respiratory burst response to phorbol myristate acetate, thereby decreasing superoxide anion (65%) and hydrogen peroxide (37%) production. Moreover an increase [correction made here after initial online publication] in monocyte plasma membrane fluidity in the hydrophilic-hydrophobic interface of the lipid bilayer was measured. Data obtained from the comet assay show that permethrin induces lymphocyte DNA lesions at both formamido pyrimidine glycosylase (Fpg) and endonuclease III (Endo III) sites in adolescent rats. Our results indicate the key role of permethrin in oxidative stress whose consequences lead to biochemical and functional changes. The reduced phagocyte respiratory burst induced by permethrin treatment and the type of DNA damage measured could represent new relevant aspects of pyrethroid toxicity which should be considered for human health.

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“…As the concentration of pyrethroids increases in the brain, so does the symptoms of neurobehavioral toxicity4. Studies from our laboratory have shown that neurobehavioral toxicity of type II pyrethroids is dependent on its metabolism, catalyzed by xenobiotic metabolizing cytochrome P450s (CYPs) in rat brain and liver56. Deltamethrin, another type II pyrethroid, was reported to induce the expression of CYP1A and 2B isoenzymes, involved in its toxicity in rat brain and liver78.…”

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confidence: 99%

Imprinting of cerebral cytochrome P450s in offsprings prenatally exposed to cypermethrin augments toxicity on rechallenge

Singh

Agrahari

Singh

et al. 2016

Sci Rep

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Epigenetic studies were carried in the rat offsprings, born to dams treated with cypermethrin (orally; 5.0 mg/kg) from gestation day (GD) 5 to 21 and rechallenged with cypermethrin (orally; 10 mg/kg for 6 days), at adulthood (12 weeks) to understand the mechanism underlying the overexpression of cerebral cytochrome P450s (CYPs) in exposed offsprings. The data revealed alterations in histone H3 acetylation and DNA methylation in promoter regions of CYP1A- and 2B- isoenzymes in the brain isolated from rechallenged animals. Further, bisulphite sequencing revealed critical CpG methylation changes in BARBIE BOX (Barbiturate response element) and BTE (Basal transcription element) in promoter of CYP2B1 in the brain isolated from rechallenged animals. Western blotting and DNA laddering/fragmentation studies revealed a greater magnitude of increase in the signalling pathways associated with apoptosis in the rechallenged animals. The data have indicated that overexpression of cerebral CYPs could be due to the imprinting of CYPs. Further, increased apoptosis observed in the rechallenged offsprings has suggested that these epigenetic changes in CYPs may predispose the prenatally exposed offsprings to the neurotoxic effects of other centrally acting drugs and chemicals when subsequently rechallenged later at life.

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Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin

Cited by 37 publications

References 26 publications

Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats

Imprinting of cerebral cytochrome P450s in offsprings prenatally exposed to cypermethrin augments toxicity on rechallenge

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