Effect of presynchronization with prostaglandin F2α before the 5-d timed AI protocol on ovarian responses and pregnancy in dairy heifers

Karakaya‐Bilen, Ebru; Ribeiro, E.S.; Bisinotto, R.S.; Gümen, Ahmet; Santos, J.E.P.

doi:10.1016/j.theriogenology.2019.03.019

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…This phase of the study was performed in Holstein heifers, because it was easier to obtain an adequate sample of animals homogeneous in age, size, weight, and ovarian stage that could be maintained in the same controlled environment within a proper handling facility. Moreover, dairy heifers show a comparable ovarian physiology to beef heifers [20,21]. Likewise, a conception rate around 60% was obtained in beef heifers, comparable to that achieved in other studies with the protocol Co-synch 72 and 56 h [9,10,13,14,16,18,24,[27][28][29][30][31].…”

Section: Discussionsupporting

confidence: 81%

“…We found no difference on follicle size around 12.8 ± 2.29 mm before AI across all protocols, also, without differences to the 13.4 ± 0.3 mm reported for beef heifers under the 7-d and 5d Co-synch 72-h protocols [61] and the 11.0 ± 0.5 mm reported for dairy heifers under the 5d Co-synch 72-h protocol with PGF2α presynchronization at two days prior to IPD insertion [21]. Therefore, delaying removal of the intravaginal progesterone device may not meaningfully reduce the TSR.…”

Section: Discussionmentioning

confidence: 63%

“…However, an FTAI protocol in which cows received prostaglandin three days before the protocol began and then were artificially inseminated at 66 h after IPD removal led to a higher percentage of cows showing a new follicular wave after the initial GnRH as well as higher conception rate than the classical 5d Co-synch 72-h protocol [20]. Such pre-synchronization has been associated with higher CR in dairy heifers [21], higher fertility rate after FTAI in multiparous beef cattle [20], and greater ovarian synchronization in beef heifers [22]. In beef heifers, however, another study did not observe different CRs between the 5d Co-synch 72-h protocol and a prostaglandin 6d-IPD protocol, consisting of prostaglandin (25 mg) on Day −9, GnRH (100 µg) and IPD insertion on Day −6, PG and IPD removal on Day 0, and FTAI at 66 h after IPD removal [23].…”

Section: Introductionmentioning

confidence: 99%

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Effects on Synchronization and Reproductive Efficiency of Delaying the Removal of the Intravaginal Progesterone Device by 24 h in the 5d Co-Synch Protocol in Heifers

Fernández-Novo

Santos-Lopez

Pesantez-Pacheco

et al. 2021

Animals

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In beef herds, increasing animal welfare, improving reproductive performance and easing animal management are key goals in farm economics. We explored whether delaying the removal of the intravaginal progesterone device by 24 h in heifers synchronized with a 5d Co-synch 72-h protocol could improve reproductive efficiency of fixed-time artificial insemination (FTAI). In experiment 1, we examined the total synchronization rate (TSR) in cycling Holstein heifers. Heifers (13.4 ± 0.69 mo.) were randomly assigned to the standard 5d Co-synch 56-h protocol (5dCo56; n = 10), 5d Co-synch 72-h (5dCo72; n = 17), or the modified 5d Co-synch 72-h protocol, in which removal of the progesterone device was delayed by 24 h (6dCo48; n = 19). In experiment 2, 309 cycling beef heifers on 18 commercial farms were subjected to the 5d Co-synch 72-h or 6-d Co-synch 48-h protocol and conception rate (CR) studied. In experiment 1, the three protocols led no differences on TSRs of 80.0% (5dCo56), 88.2% (5dCo72), and 89.5% (6dCo48). In experiment 2, the CR from the beef heifers, observed during two consecutive reproductive seasons did not differ: 59.7% for 5dCo72 and 62.0% for 6dCo48 (p = 0.907). Therefore, delaying removal by 24 h provides satisfactory results without reducing reproductive efficiency of heifers.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Effects on Synchronization and Reproductive Efficiency of Delaying the Removal of the Intravaginal Progesterone Device by 24 h in the 5d Co-Synch Protocol in Heifers

Fernández-Novo

Santos-Lopez

Pesantez-Pacheco

et al. 2021

Animals

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“…We found no difference on follicle size around 12.8 ± 2.29 mm before AI across all protocols, also, without differences to the 13.4 ± 0.3 mm reported for beef heifers under the 7d and 5d Co-synch 72 h protocols [62] and the 11.0 ± 0.5 mm reported for dairy heifers under the 5d Co-synch 72 h protocol with PGF 2α presynchronization at 2 days prior to IPD insertion [40]. Therefore, delaying removal of the intravaginal progesterone device did not reduce the TSR.…”

Section: Discussioncontrasting

confidence: 49%

Effects of delaying the removal of the intravaginal progesterone device by 24 h in the 5d Co-synch protocol in heifers

Fernández-Novo¹,

Santos-Lopez

Pesantez-Pacheco

et al. 2021

Preprint

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Background In beef herds, increasing animal welfare, improving reproductive performance and easing animal management are key goals in farm economics. This study explored whether delaying the removal of the intravaginal progesterone device by 24 h in heifers synchronized with a 5d Co-synch 72 h protocol could improve reproductive efficiency of fixed-time artificial insemination (FTAI). In Experiment 1, we examined whether such a modified protocol would provide an acceptable, total synchronization rate (TSR) in cycling Holstein heifers. Heifers (13.4 ± 0.69 mo.) were randomly assigned to the standard 5d Co-synch 56 h protocol (5dCo56; n = 10), the standard 5d Co-synch 72 h protocol (5dCo72; n = 17), or the modified 5d Co-synch 72 h protocol, in which removal of the progesterone device was delayed by 24 h (6dCo48; n = 19). Heifers were considered synchronized (TSR) if serum progesterone value > 1.0 ng/mL and the corpus luteus (CL) was detectable by ultrasonography on Day 5, if progesterone < 1.0 ng/mL and at least one follicle had a diameter > 8 mm on Day 7.5, and if progesterone > 1.0 ng/mL and CL was detectable on Day 15. In Experiment 2, 309 cycling beef heifers on 18 commercial farms were subjected to the 5d Co-synch 72 h or 6d Co-synch 48 h protocol and conception rate (CR) studied. Results In experiment 1, the three protocols in dairy heifers led no differences on TSRs of 80.0% (5dCo56), 88.2% (5dCo72) and 89.5% (6dCo48). In experiment 2, the CR from the beef heifers, observed during two consecutive reproductive seasons did not differ: 59.7% for 5dCo72 and 62.0% for 6dCo48 (P = 0.907). Heifer age, body condition score or stress score did not significantly affect conception rate. Conclusions These results suggest that delaying removal of the intravaginal progesterone device by 24 h during the standard 5d Co-synch 72 h protocol provides satisfactory results without reducing reproductive efficiency of heifers.

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“…Several studies have shown the superiority of the double OvSynch program and other GnRH based presynchronization programs compared to the PGF2α presynchronization in terms of pregnancy rate (Souza et al, 2008;Bilgen and Ozenc, 2010;Herlihy et al, 2012;Ayres et al, 2013;Dirandeh et al, 2015;Karakaya-Bilen et al, 2019;Luchterhand et al, 2019;. In one study, pregnancy per AI for primiparous and multiparous lactating dairy cows was respectively 52.5% and 40.3% following Double-Ovsynch and 42.3% and 34.3% after Presynch-Ovsynch (Herlihy et al, 2012).…”

Section: Synchronization and Tai For Dairy Heifersmentioning

confidence: 99%

Synchronization of Estrus and Ovulation in Dairy Cattle

Tibary¹,

Patino²,

Ciccarelli³

2019

SPERMOVA

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Development of bovine estrus synchronization protocols started in the 1970's. The aim of these protocols has changed progressively from synchronizing estrus to synchronizing ovulation with main goal of performing insemination without heat detection (Timed artificial insemination). The present paper discusses the physiology behind development of these synchronization protocols and reviews of the main protocols used nowadays in dairy herd reproductive management. RESUMENEl desarrollo de los protocolos de sincronización del celo en bovinos comenzó en la década de 1970. El objetivo de estos protocolos ha cambiado progresivamente de la sincronización del celo a la sincronización de la ovulación con el objetivo de realizar la inseminación sin detección de celo (inseminación artificial a tiempo fijo). El presente artículo discute la fisiología detrás del desarrollo de estos protocolos de sincronización y las revisiones de los principales protocolos utilizados hoy en día en el manejo reproductivo del hato lechero.

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Effect of presynchronization with prostaglandin F2α before the 5-d timed AI protocol on ovarian responses and pregnancy in dairy heifers

Cited by 13 publications

References 24 publications

Effects on Synchronization and Reproductive Efficiency of Delaying the Removal of the Intravaginal Progesterone Device by 24 h in the 5d Co-Synch Protocol in Heifers

Effects on Synchronization and Reproductive Efficiency of Delaying the Removal of the Intravaginal Progesterone Device by 24 h in the 5d Co-Synch Protocol in Heifers

Effects of delaying the removal of the intravaginal progesterone device by 24 h in the 5d Co-synch protocol in heifers

Synchronization of Estrus and Ovulation in Dairy Cattle

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