Effect of pressure cooking on phenolic compounds of quinoa

Ma, Qianwei; Li, Zhixiang; Kumrungsee, Thanutchaporn; Huang, Wenda; Cao, Ruge

doi:10.1016/j.gaost.2023.03.001

Cited by 1 publication

(2 citation statements)

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“…Thus, many researchers have concentrated on using plant-derived bioactive compounds as complementary medicine for the treatment of NAFLD due to their excellent effects and high security, particularly from medicinal and edible plants [ 4 , 5 ]. Polyphenol is an important type of plant-derived bioactive compound and a promising potential candidate for the treatment of metabolic disorders because of its wide spectrum of biological properties [ 6 , 7 , 8 ]. Certain polyphenols have the potential to modify multiple pathways, including those in the liver, gut, and brain, as well as the interconnections between these pathways, thereby improving various pathological indicators in patients with NAFLD [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Polyphenol is an important type of plant-derived bioactive compound and a promising potential candidate for the treatment of metabolic disorders because of its wide spectrum of biological properties [ 6 , 7 , 8 ]. Certain polyphenols have the potential to modify multiple pathways, including those in the liver, gut, and brain, as well as the interconnections between these pathways, thereby improving various pathological indicators in patients with NAFLD [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Thyme (Thymus quinquecostatus Celak) Polyphenol-Rich Extract (TPE) Alleviates HFD-Induced Liver Injury in Mice by Inactivating the TLR4/NF-κB Signaling Pathway through the Gut–Liver Axis

Sheng

Wang

Zhan

et al. 2023

Foods

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Non-alcoholic fatty liver disease (NAFLD) represents a significant and urgent global health concern. Thyme (Thymus quinquecostatus Celak) is a plant commonly used in cuisine and traditional medicine in Asian countries and possesses potential liver-protective properties. This study aimed to assess the hepatoprotective effects of thyme polyphenol-rich extract (TPE) on high-fat diet (HFD)-induced NAFLD and further explore possible mechanisms based on the gut–liver axis. HFD-induced liver injury in C57 mice is markedly ameliorated by TPE supplementation in a dose-dependent manner. TPE also regulates the expression of liver lipid metabolic genes (i.e., Hmgcr, Srebp-1, Fasn, and Cyp7a1), enhancing the production of SCFAs and regulating serum metabolites by modulating gut microbial dysbiosis. Furthermore, TPE enhances the intestinal barrier function and alleviates intestinal inflammation by upregulating tight junction protein expression (i.e., ZO-1 and occluding) and inactivating the intestinal TLR4/NF-κB pathway in HFD-fed mice. Consequently, gut-derived LPS translocation to the circulation was blocked, the liver TLR4/NF-κB signaling pathway was repressed, and subsequent pro-inflammatory cytokine production was restrained. Conclusively, TPE might exert anti-NAFLD effects through the gut–liver axis and has the potential to be used as a dietary supplement for the management of NAFLD.

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