Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions

Asare-Addo, Kofi; Alshafiee, Maen; Walton, Karl; Ward, Adam; Totea, Ana-Maria; Taheri, Sadaf; Mawla, Nihad; Adebisi, Adeola O.; Elawad, Sheima; Diza, Chantel; Timmins, Peter; Conway, Barbara R.

doi:10.1016/j.ejpb.2019.03.002

Cited by 14 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UV imaging has also been useful in other applications, such as biorelevant characterisation of salts, solid dispersions, transdermal patches, and hydrogels (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Alongside, the potential of the technique in relation to quality control assessment has been suggested (20,34,37).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging

Brown

Fazili

Ward

et al. 2021

Journal of Drug Delivery Science and Technology

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to characterize compact surfaces (surface roughness) and study its potential importance to the intrinsic dissolution rate (IDR) as determined by dissolution imaging. To this end, the effect of varying compaction pressures and the use of two stainlesssteel surfaces with different textures/roughness on the intrinsic dissolution were investigated. Ketoprofen (KET), paracetamol (PAR) and ibuprofen (IBU) were compacted and a focus variation microscope used to determine the surface topology of the compacts. IDR determination was conducted using a surface dissolution imaging apparatus with the flowthrough set up in phosphate buffer at pH 7.2 and 37 °C. The results indicated a general decrease in the surface area of the drug compacts with an increase in compaction force, p values < 0.05 for IBU and PAR but not KET. This change in surface area was measured using the Sdr parameter, which can be defined as the developed interfacial area. The smoother stainless-steel plate insert produced significantly smoother compacts for KET (Sdr decreased from 0.30 % to 0.07 %). However, PAR and IBU compacts showed an increase in their Sdr values from 3.94 % to 17.90 % and from 0.60 % to 0.83 %, respectively, suggesting the changes in surface properties to be drug specific relating to poor compaction properties and elasticity. The dissolution studies suggested that low compaction forces were not suitable for PAR. Overall changes in the surface topology did not have a significant effect on the obtained IDR values.

show abstract

Section: Introductionmentioning

confidence: 99%

“…This combination was used to analyse drug content of drug-excipient compacts prior to IDR determination with an Actipix SDI 300 (39). Focus variation microscopy has also been employed to suggest that rough drug compact surfaces, may increase the variation of IDR measurements (14,34,35).…”

Section: Introductionmentioning

confidence: 99%

An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging

Brown

Fazili

Ward

et al. 2021

Journal of Drug Delivery Science and Technology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Asare-Addo et al 2019 also investigated a spray drying, freeze-drying and homogenizing-freeze drying technique on indomethacin soluplus amorphous solid dispersions. The authors also found the different manufacturing techniques to impact on the surface properties of compacts for intrinsic dissolution rate (IDR) measurements [46]. The impact of the freeze-drying processes on the dissolution rate of solid dispersions containing D-glucosamine HCl (GLU and PXM ((4-hydroxy-2-methyl-N-(2piridyl) 2H-1,2-benzothiazine-3-carboxamide-1, 1-dioxide) and its impact of the charging properties were assessed in this study.…”

Section: Introductionmentioning

confidence: 99%

Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements

Adebisi

Kaialy

Hussain

et al. 2021

Journal of Drug Delivery Science and Technology

Self Cite

View full text Add to dashboard Cite

“…Biopharmaceutics classification system (BCS) Class II drugs are characterized by low solubility and high membrane permeability, so that the dissolution of drugs from dosage formulation is the ultimate rate-limiting step [1], resulting in high permeability but low bioavailability. Many strategies have been applied to improve the dissolution rate and bioavailability of active pharmaceutical ingredients (APIs) including formulation changes, industry strategies, method optimum, etc.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

Xi¹,

Zhang²,

Fei³

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients-hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)-combined with mesoporous silica nanoparticles (MSNs) as carriers were investigated. The IMC-SDs were prepared using the solvent evaporation method and characterized by solubility analysis, infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), and differential scanning calorimetry (DSC). It was confirmed that IMC successfully changed into an amorphous state after loading into the designed carriers. The in vitro release and stability experiments were conducted to examine the in vitro dissolution rates of IMC-SDs combined with HPMC and Kollicoat IR as PIs which both improved approximately three-fold to that of the pure drug. Finally, in vivo studies and in vitro parallel artificial membrane penetration (PAMPA) experiments ensured the greater ability of enhancing the dissolution rates of pure IMC in the gastrointestinal tract by oral delivery. In brief, this study highlights the prominent role of HPMC and Kollicoat IR as PIs in MSN SD systems in improving the bioavailability and gastrointestinal oral absorption efficiency of indomethacin.

show abstract

Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions

Abstract: Submission: European Journal of Pharmaceutics and Biopharmaceuticsthe dissolution of indomethacin. This work thus highlights the importance of having both complimentary IDR and whole dosage imaging techniques in giving a better understanding of solid dispersion systems.

Cited by 14 publications

References 46 publications

An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging

An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging

Freeze-dried crystalline dispersions: Solid-state, triboelectrification and simultaneous dissolution improvements

Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

Contact Info

Product

Resources

About