Effect of Preoperative Neornycin-Erythromycin Intestinal Preparation on the Incidence of Infectious Complications Following Colon Surgery

Clinical Studies of 4 Methods of Bowel Preparation in Colorectal Surgery

“…Our number of procedures, 53. is small when compared with some retrospective sc ries like that of Degennaro et al [9], but com pares well with other prospective studies, for example those of Nichols et al [18] and Feathers et al [11] who studied 20 and 52 patients, respectively. Although 25 out of the 53 procedures were closure of colostomy, these closures were not always minor, as some of them (especially the colostomies constructed in the newborn period) required bowel resection to effect a safe closure.…”

Sacrocolpopexy for Post Hysterectomy Vault Prolapse

“…Bowel preparations with antibiotics have been utilized including a Nichols bowel preparation [Nichols, 1973] with oral neomycin and erythromycin, but these are not encouraged, recommended or, necessary. Intravenous antibiotics are administered in preoperative holding one hour prior to the incision continued for a minimum of twenty-four hours postoperatively.…”

Standards of Antibiotic Prophylaxis in Abdominal Surgery

“…The most common pathogens are Escherichia coli and Bacteroides fragilis. When antibiotic prophylaxis is not employed, reported wound infection rates after colonic surgery vary from over 20% to 77% [4,10,33,[41][42][43][44][45], A positive effect can be obtained by orthograde rinsing [12], In the United States, the nonabsorbable enteral preparation of oral neomycin and an erythromycin base is the favorite means of antibi otic prophylaxis and has been shown to be one of the most effective or even the best antibiotic regimen in colorectal surgery compared to systemic administration [46][47][48][49][50][51][52], Other studies have shown higher infection rates with oral antibiotics [53][54][55], although the intraluminal concentra tions of organisms were significantly lower than those found in the parenteral group. This suggests that it is tis sue concentration rather than intracolonic concentration that is critical in preventing infection.…”