Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial

Srivastava, Uma; Kumar, Aditya; Saxena, SK; Mishra, Abhijeet Rajan; Saraswat, Namita; Mishra, Sukhdev

doi:10.1097/eja.0b013e328334de85

Cited by 39 publications

(58 citation statements)

References 17 publications

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“…2) Gabapentin is efficacious against various pain syndromes such as neuropathic pain, chronic pain, and postoperative pain. 4,[6][7][8][9]12,13) Gabapentin monotherapy is recommended to provide pain relief and to increase the overall quality of life in patients with chronic radicular pain, 14) but the evidence for efficacy against acute pain is limited. 1,2,12) This prospective study analyzed the effects of gabapentin on reduction of the severity of radicular pain, and improvement of the quality of life in patients with LDH and/or LSS over a relatively short period.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Gabapentin for Radiculopathy Caused by Lumbar Spinal Stenosis and Lumbar Disk Hernia

Kasımcan

Kaptan

2010

Neurol. Med. Chir.(Tokyo)

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The efficacy of gabapentin monotherapy was investigated against both acute or chronic radicular pain caused by lumbar disk hernia (LDH) or lumbar spinal stenosis (LSS). Seventy-eight patients with radicular pain, 10 males and 68 females aged 23 to 76 years (mean 49.4 years), caused by LSS in 45 patients or LDH in 33 patients were treated with oral administration of gabapentin and were followed up for 3 months. The evaluation included neurological examination, Odom's criteria, visual analog pain scale (VAS), and walking distance. Gabapentin treatment resulted in decreased VAS scores in both groups. Odom's criteria scores had improved to excellent or good in 36 patients with LSS and 28 patients with LDH. Furthermore, walking distance was significantly longer at the 3rd month of the treatment protocol. Eight patients discontinued gabapentin therapy because of the side effects. Gabapentin could be an option in the conservative management of acute or chronic radicular pain.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Gabapentin for Radiculopathy Caused by Lumbar Spinal Stenosis and Lumbar Disk Hernia

Kasımcan

Kaptan

2010

Neurol. Med. Chir.(Tokyo)

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“…Eight trials were classified as overall low risk of bias, [39, 43, 46, 56, 59, 72, 73, 85] 18 trials were overall unclear risk of bias [21, 23, 24, 26, 28, 29, 31, 36, 38, 42, 52, 54, 55, 61, 65, 66, 68, 69, 80] and 48 trials were classified as high risk of bias, [20, 22, 25, 27, 30, 32–35, 37, 40, 41, 44, 45, 47–51, 53, 57, 58, 60, 62–64, 67, 70, 71, 74–79, 81–84, 86–94] (Fig. 2: Bias assessment).…”

Section: Resultsmentioning

confidence: 99%

Gabapentin in procedure-specific postoperative pain management – preplanned subgroup analyses from a systematic review with meta-analyses and trial sequential analyses

et al. 2017

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BackgroundIt has been argued that postoperative pain treatment should be “procedure-specific”, since different analgesics may have specific effects dependent on the surgical procedure. The aim of the present subgroup analysis was to compare the beneficial and harmful effects of perioperative gabapentin treatment in different surgical procedures.MethodsRelevant databases were searched for randomized clinical trials (RCTs) comparing gabapentin versus placebo. Two authors independently screened titles and abstracts, extracted data and assessed risk of bias. The primary outcomes were differences in 24-h morphine consumption, and serious adverse events (SAE) between surgical procedures. These subgroup analyses were predefined in a PRISMA compliant systematic review registered at PROSPERO (ID: CRD42013006538). It was predefined that conclusions should primarily be based on trials classified as overall low risk of bias.ResultsSeventy-four RCTs with 5645 patients were included, assessing benefit and harm in cholecystectomy, hysterectomy, mastectomy, and arthroplasty surgery, spinal surgery, and thoracic surgery.Only eight of 74 trials were classified as overall low risk of bias limiting our ability to conclude on the estimates in most meta-analyses. The differences between surgical procedures in these trials were not statistically significant when tested for subgroup differences. Fifteen trials with 1377 patients reported a total of 59 SAEs, most of which were observed in the thoracic surgery group.ConclusionBoth beneficial and harmful effects in these subgroup analyses were influenced by bias and insufficient data, limiting conclusions. With these limitations, we could not adequately test for differences in beneficial or harmful outcomes between six surgical subgroups undergoing perioperative gabapentin treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12871-017-0373-8) contains supplementary material, which is available to authorized users.

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“…30,31 A single dose of pregabalin 150 mg demonstrates similar efficacy to gabapentin in reducing postoperative pain and opioid consumption. 27 A 50% reduction in 24-hour morphine consumption and decreased nausea and vomiting was observed after a 1-time dose of pregabalin 300 mg in patients undergoing total hip arthroplasty. 22 Buvanendran and colleagues 25 demonstrated pregabalin (300 mg 1-time dose followed by 150 mg twice a day) administered in the perioperative period not only decreases the development of chronic pain, but improves surgical outcome as demonstrated with greater range on motion after total knee arthroplasty.…”

Section: Anticonvulsantsmentioning

confidence: 97%

“…Half that dose, gabapentin 600 mg, given 2 hours preoperatively was effective in reducing pain scores and tramadol consumption by 33% after mini-laparotomy open cholecystectomy in the same time frame; however, pain scores and tramadol consumption returned to similar levels on postoperative day 2. 27 Continuing administration of gabapentin, in addition to a single preoperative dose, appears to have benefit; when given 4 days postoperatively, opioid consumption and some opioid-related side effects were reduced after total knee arthroplasty. 28 Of note, gabapentin has been studied in the pediatric population and a single preoperative dose had similar effects to those seen in the adult population, that being lower pain scores and decreased opioid consumption postoperatively.…”

Section: Anticonvulsantsmentioning

confidence: 97%

Multimodal Systemic and Intra-articular Analgesics

Young

Buvanendran

2011

International Anesthesiology Clinics

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Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial

Cited by 39 publications

References 17 publications

Efficacy of Gabapentin for Radiculopathy Caused by Lumbar Spinal Stenosis and Lumbar Disk Hernia

Efficacy of Gabapentin for Radiculopathy Caused by Lumbar Spinal Stenosis and Lumbar Disk Hernia

Gabapentin in procedure-specific postoperative pain management – preplanned subgroup analyses from a systematic review with meta-analyses and trial sequential analyses

Multimodal Systemic and Intra-articular Analgesics

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