Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring

Rayburn, William F.; Gonzalez, Christina L.; Christensen, H.Dix; Stewart, Jeffrey D.

doi:10.1067/mob.2001.108339

Cited by 40 publications

(22 citation statements)

References 9 publications

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“…Rayburn et al [39] showed that prenatal exposure to a therapeutic dose of SJW caused no deficit in long-term behavioral tasks in the offspring of mice. Rayburn et al [40] also indicated that maternal administration of SJW before and during pregnancy did not affect the growth or physical maturation of the progeny of exposed rats.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Perón

Mariucci

Almeida

et al. 2013

BMC Complement Altern Med

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BackgroundSt. John’s wort (Hypericum perforatum L.) is an herbaceous plant that is native to Europe, West Asia and North Africa and that is recognized and used worldwide for the treatment of mild and moderate depression. It also has been shown to be therapeutic for the treatment of burns, bruises and swelling and can be used for its wound healing, antiviral, antimicrobial, antioxidant, analgesic, hepato-protective and anxiolytic properties. The aim of this study was to evaluate the potential cytotoxic, mutagenic and antimutagenic action of H. Perforatum.MethodsMeristematic cells were used as the test system for Allium cepa L., and bone marrow cells from Rattus norvegicus, ex vivo, were used to calculate the mitotic index and the percentage of chromosomal aberration. Statistical analysis was performed using the chi-square test.ResultsThis medicinal plant had no cytotoxic potential in the vegetal test system evaluated. In the animal test system, none of the acute treatments, including intraperitoneal gavage and subchronic gavage, were cytotoxic or mutagenic. Moreover, this plant presented antimutagenic activity against the clastogenic action of cyclophosphamide, as confirmed in pre-treatment (76% reduction in damage), simultaneous treatment (95%) and post-treatment (97%).ConclusionsThus, the results of this study suggest that the administration of H. perforatum, especially by gavage similar to oral consumption used by humans, is safe and with beneficial antimutagenic potential.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Perón

Mariucci

Almeida

et al. 2013

BMC Complement Altern Med

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“…More complex is the issue of potential damages to the foetus, since teratogenic effects of most of herbs are not fully ascertained. None of the published studies identified an increased risk for the unborn child, but these studies were small and could not rule out negative effects on pregnancy outcome 19, 31–33…”

Section: Discussionmentioning

confidence: 99%

Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome

Cuzzolin¹,

Francini-Pesenti²,

Verlato³

et al. 2010

Pharmacoepidemiology and Drug

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“…A small number of animal studies have shown that HP does not affect cognitive development, long‐term growth, or physical maturation and causes no long‐term behavioural deficits. However, other animal studies have reported lower birth weights in offspring when HP was consumed during pregnancy and that HP may increase uterine tone (Rayburn et al ., , , ; Dugoua et al ., ). Furthermore, Gregoretti et al .…”

Section: Safety Of Hypericum Perforatummentioning

confidence: 99%

Hypericum perforatum : Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

et al. 2013

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Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. The medicinal form comprises the leaves and flowering tops of which the primary ingredients of interest are naphthodianthrones, xanthones, flavonoids, phloroglucinols (e.g. hyperforin), and hypericin. Although several constituents elicit pharmacological effects that are consistent with HP's antidepressant activity, no single mechanism of action underlying these effects has thus far been found. Various clinical trials have shown that HP has a comparable antidepressant efficacy as some currently used antidepressant drugs in the treatment of mild/moderate depression. Interestingly, low-hyperforin-content preparations are effective in the treatment of depression. Moreover, HP is also used to treat certain forms of anxiety. However, HP can induce various cytochrome P450s isozymes and/or P-glycoprotein, of which many drugs are substrates and which are the main origin of HP-drug interactions. Here, we analyse the existing evidence describing the clinical consequence of HP-drug interactions. Although some of the reported interactions are based on findings from in vitro studies, the clinical importance of which remain to be demonstrated, others are based on case reports where causality can, in some cases, be determined to reveal clinically significant interactions that suggest caution, consideration, and disclosure of potential interactions prior to informed use of HP.

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Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring

Cited by 40 publications

References 9 publications

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome

Hypericum perforatum : Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

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