Effect of prenatal tramadol on postnatal cerebellar development: Role of oxidative stress

Aboulhoda, Basma Emad; Hassan, Sherif S.

doi:10.1016/j.jchemneu.2018.10.002

Cited by 18 publications

(12 citation statements)

References 58 publications

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“…A study carried out by Sabir et al (2018) showed fentanyl induced apoptosis of the Granule cells of the internal layer in 13 healthy newborn pigs. Aboulhoda and Hassan (2018) detected a relationship between tramadol administration during pregnancy, oxidative stress, and structural abnormalities on the post-natal cerebellar cortex in a group of rats. Finally, another study demonstrated the possible effects of opioids administered during the developmental period on the NMDA receptor (NMDAR) expression and function, exploiting animal models.…”

Section: Cerebellar Neuropathologymentioning

confidence: 90%

Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events

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Amore

Vetri

et al. 2021

Front. Syst. Neurosci.

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The cerebellum plays a critical regulatory role in motor coordination, cognition, behavior, language, memory, and learning, hence overseeing a multiplicity of functions. Cerebellar development begins during early embryonic development, lasting until the first postnatal years. Particularly, the greatest increase of its volume occurs during the third trimester of pregnancy, which represents a critical period for cerebellar maturation. Preterm birth and all the related prenatal and perinatal contingencies may determine both dysmaturative and lesional events, potentially involving the developing cerebellum, and contributing to the constellation of the neuropsychiatric outcomes with several implications in setting-up clinical follow-up and early intervention.

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Section: Cerebellar Neuropathologymentioning

confidence: 90%

Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events

Spoto

Amore

Vetri

et al. 2021

Front. Syst. Neurosci.

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“…Moreover, the main mechanism of drug toxicity and destruction of epididymal mucosa is oxidative damage that enhances generation of free radicals and induces tissue necrosis [24]. Effects of ROS include multiple cell injuries as membranous lipid peroxidation, oxidative modification of proteins, membrane damage, DNA lesions and altered gene expression that induce cell degeneration, cytoplasmic vacuolation, changes of caspase-3 expression and apoptosis of epithelial cells [25].…”

Section: Discussionmentioning

confidence: 99%

Effects of Thymoquinone on Tramadol Induced Toxicity in Epididymis of Adult Male Rabbits (Histological & Immunohistochemical Study)

Mousa¹

2019

IJCDA

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Millions of patients who administer or abuse tramadol to relieve chronic pain may suffer from infertility. Thymoquinone (TQ) is a major active component of nigella sativa oil, which has antioxidant and anti-inflammatory effects. The present work aimed to clarify effects of tramadol and TQ on epididymis of adult male rabbits. Forty adult male rabbits aged 3 months were used for one month & divided equally into 4 groups: Group 1 as a control group; group 2 was treated with tramadol 30 mg/kg orally/day, group 3 was treated with TQ 20 mg/kg orally/day and group 4 as a protected group that was treated with TQ 20 mg/kg & tramadol 30 mg/kg orally/day. The epididymis was processed for histological and immunohistochemical (IHC) study for detection of epididymal structure and caspase-3 as an indicator of epididymal apoptotic changes. Statistical analysis of apoptotic index, area% of collagen and caspase-3 immunoexpression was carried out. Group 2 showed epithelial thinning of epididymal wall, degeneration and vacuolation of epithelial cells with disturbance of stromal collagen fibers. Also, a significant increase of apoptotic index, area % of collagen and caspase-3 cytoplasmic immunoexpression in epididymal epithelium was noticed in group 2. While, Group 3 and 4 showed improvement of the histological and IHC changes described in group 2. It is concluded that tramadol intake exerted toxic effects on epididymal structure while, TQ minimized these effects. Therefore, intake of TQ with tramadol is advised to protect the epididymis from the hazardous effects of tramadol abuse.

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“…The pregnancy of rats was confirmed by the presence of a vaginal plug. After that, the pregnant female rats were randomly allocated into three main groups; control, tramadol treated and tramadol + thyme treated (Aboulhoda andHassan, 2018, Sarhan andTaalab, 2018). Each main group was further subdivided into 3 subgroups as follows: 1-Control Group: The pregnant female rats from day one of pregnancy till the end of weaning have not received any medications for 8 weeks.…”

Section: Iii-the Experimental Designmentioning

confidence: 99%

“…Tramadol causes oxidative stress in the progeny cerebellum. This was demonstrated by an increase in lipid peroxidation and a reduction in the antioxidant enzymes' activity (Aboulhoda and Hassan, 2018). Tramadol inhibits the antioxidant enzymes in the mitochondria of cerebellar neurons, resulting in the production of reactive oxygen species that cause cell injury (Mohammadnejad andSoltaninejad, 2022 , Mohamed et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Co-Administration of Thyme and Tramadol on The Postnatal Development of Purkinje Neurons of The Albino Rat

Mohamed

Mohamed²,

Ghait³

2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Background: Tramadol is a painkiller that works by acting on the central nervous system. Even though tramadol is regarded to have minimal misuse and dependence potential, it is increasingly being used in pregnant women in many countries throughout the world, notably in the Middle East, Africa, and West Asia, to relieve pain from rheumatoid arthritis, cancer, and other diseases. Aim of the work: To assess the harmful effects of tramadol on the postnatal development of the cerebellar Purkinje cells of rats and to evaluate the possible ameliorative effect of thyme if being administered with tramadol simultaneously. Material & Methods: Three sets of Forty-eight mature female albino rats were randomly organized into three equal groups; Group 1 (control), group 2 (tramadol treated) and group 3 ( tramadol+thyme treated). The rats' offspring of the fore mentioned three groups were further subdivided according to their ages into 3 subgroups (newborn, 10 th, and 20 th postnatal day). Group I have not received any treatment. Tramadol HCL (40 mg/Kg/day) dissolved in tab water was given orally to group B. Tramadol (40 mg/Kg/day) and thyme extract (500 mg/kg/day) were given orally to group C. From the first day of pregnancy until weaning, female rats were administered tramadol and thyme. For each of the three groups, the Purkinje cell layer of the cerebellar cortex of the rats' offspring (newborn, 10 th, and 20 th postnatal day) was then examined for histological, ultrastructural, immunohistochemical changes and morphometric analysis. Results: Histological, ultrastructural and immunohistochemistry studies showed that in GII there were neuronal frittering and apoptotic changes in the Purkinje neurons. In GIII, an improvement in histological, ultrastructural and immunohistochemical changes was observed. The morphometric results revealed that there was a significant statistical difference at 10 th and 20 th postnatal age whereas no recorded significant statistical difference at newborn age among the experimental groups. Conclusion: Tramadol use during pregnancy and breastfeeding had a neurotoxic impact on the development of Purkinje cells of the cerebellar cortex of rats. Thyme extract can ameliorate the tramadol's harmful effects; hence it may be useful in the therapy of tramadol neuronal damage if tramadol is required.

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Effect of prenatal tramadol on postnatal cerebellar development: Role of oxidative stress

Cited by 18 publications

References 58 publications

Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events

Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events

Effects of Thymoquinone on Tramadol Induced Toxicity in Epididymis of Adult Male Rabbits (Histological & Immunohistochemical Study)

Effects of the Co-Administration of Thyme and Tramadol on The Postnatal Development of Purkinje Neurons of The Albino Rat

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