Effect of prenatal steroid treatment on the developing immune system

Diepenbruck, Ines; Much, Chressen; Krumbholz, Aniko; Kolster, Manuela; Thieme, René; Thieme, Detlef; Diepenbruck, Silke; Solano, María Emilia; Arck, Petra C.

doi:10.1007/s00109-013-1069-2

Cited by 29 publications

(29 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported that prenatal TCDD could promote the thymocyte apoptosis and finally resulted in thymus atrophy in offspring48. In addition, prenatal betamethasone exposure could induce the apoptosis of DP, and reduce the proliferation of immature thymocytes49. In our study, the results of both TEM and flow cytometry showed that the total apoptosis rate of fetal thymocyte in nicotine group was increased.…”

Section: Discussionsupporting

confidence: 51%

Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice

Chen

Yan

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Nicotine, a definite risk factor during pregnancy, is an immunomodulator. This study was designed to investigate the effects of prenatal nicotine exposure (PNE) on the balance of Th1/Th2 in offspring, and further explore the developmental origin mechanisms from the perspective of fetal thymocytes apoptosis. Pregnant Balb/c mice were administered 1.5 mg/kg nicotine subcutaneously twice per day from gestational day (GD) 9 to GD18. Results showed that PNE could cause a Th2 shift in male offspring, manifested as increased ratio of IgG1/IgG2a, IL-4 production in serum, and IL-4/IFN-γ expression ratio in spleen. Increased apoptosis of total thymocytes and CD4SP and reduced cell proportion of CD4SP were found in PNE male offspring on postnatal day (PND) 14 and PND 49. In the fetuses, decreased body weight and organ index of fetal thymus, histological changes in fetal thymus, reduced CD4SP proportion and increased fetal thymocyte apoptosis were observed in nicotine group. The increased mRNA expression of genes involved in Fas-mediated apoptotic pathway and protein expression of Fas were also detected. In conclusion, PNE could cause a Th2 shift in male offspring mediated by reduced CD4+ T cells output, which may result from the increasing apoptosis of total thymocytes and CD4SP.

show abstract

Section: Discussionsupporting

confidence: 51%

Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice

Chen

Yan

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…route, and lymphocyte suppression was also comparable for the BetaP plus BetaA. A concern for clinical use is that corticosteroids have large effects on the developing immune system of the fetus that could alter immune function in the child and adult …”

Section: Discussionmentioning

confidence: 87%

“…A concern for clinical use is that corticosteroids have large effects on the developing immune system of the fetus that could alter immune function in the child and adult. [33][34][35] The study has limitations as we studied only fasted healthy Indian-Asian women. Extrapolation to other populations of different racial backgrounds, a wide range of BMI, nonfasted, and pregnant women must be done with caution.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India

Jobe

Milad²,

Peppard

et al. 2019

Clinical Translational Sci

View full text Add to dashboard Cite

High‐dose betamethasone and dexamethasone are standard of care treatments for women at risk of preterm delivery to improve neonatal respiratory and mortality outcomes. The dose in current use has never been evaluated to minimize exposures while assuring efficacy. We report the pharmacokinetics and pharmacodynamics (PDs) of oral and intramuscular treatments with single 6 mg doses of dexamethasone phosphate, betamethasone phosphate, or a 1:1 mixture of betamethasone phosphate and betamethasone acetate in reproductive age South Asian women. Intramuscular or oral betamethasone has a terminal half‐life of 11 hours, about twice as long as the 5.5 hours for oral and intramuscular dexamethasone. The 1:1 mixture of betamethasone phosphate and betamethasone acetate shows an immediate release of betamethasone followed by a slow release where plasma betamethasone can be measured out to 14 days after the single dose administration, likely from a depo formed at the injection site by the acetate. PD responses were: increased glucose, suppressed cortisol, increased neutrophils, and suppressed basophils, CD3CD4 and CD3CD8 lymphocytes. PD responses were comparable for betamethasone and dexamethasone, but with longer times to return to baseline for betamethasone. The 1:1 mixture of betamethasone phosphate and betamethasone acetate caused much longer adrenal suppression because of the slow release. These results will guide the development of better treatment strategies to minimize fetal and maternal drug exposures for women at risk of preterm delivery.

show abstract

“…High levels of the later were shown to cause apoptosis of thymocytes resulting in the gland's involution . The thymus was shown to reduce in size after exposure to synthetic steroids (Betamethasone) in fetal mouse and ovine models and in human thymocytes …”

Section: Changes In Thymus Sizementioning

confidence: 99%

The use of imaging technology in the assessment of the fetal inflammatory response syndrome—imaging of the fetal thymus

et al. 2015

View full text Add to dashboard Cite

The fetal inflammatory response syndrome (FIRS) describes a state of extensive fetal multi organ involvement during chorioamnionitis, and is associated with grave implications on perinatal outcome. The syndrome has been linked to the preterm parturition syndrome and is associated with inflammation/infection processes in most of the fetal organs. The fetal thymus, a major organ in the developing immune system involutes during severe neonatal disease and has been shown to be smaller in fetuses with FIRS. Various methods for imaging of the fetal thymus and measurement are described. Currently the only method to diagnose FIRS prenatally is through amniocentesis. We suggest that women who are admitted with preterm labor with intact membranes and those with PPROM should have a detailed sonographic examination of the fetal thymus as a surrogate marker of fetal involvement in intrauterine infection/inflammation processes.

show abstract

Effect of prenatal steroid treatment on the developing immune system

Cited by 29 publications

References 36 publications

Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice

Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice

Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India

The use of imaging technology in the assessment of the fetal inflammatory response syndrome—imaging of the fetal thymus

Contact Info

Product

Resources

About