Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature

Moral, Raquel; Wang, Thomas J.; Russo, Irma H.; Lamartiniere, Coral A.; Pereira, Julia; Russo, José

doi:10.1677/joe-07-0056

Cited by 145 publications

(106 citation statements)

References 76 publications

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“…Furthermore, rats exposed to BPA in utero developed precancerous and cancerous lesions (32). Also, perinatal exposure increased rodents' sensitivity to chemical carcinogens (33)(34)(35)(36). Although a small human study found no association between To whom correspondence should be addressed.…”

mentioning

confidence: 99%

Bisphenol A alters the development of the rhesus monkey mammary gland

Tharp

Maffini

Hunt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

152

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The xenoestrogen bisphenol A (BPA) used in the manufacturing of various plastics and resins for food packaging and consumer products has been shown to produce numerous endocrine and developmental effects in rodents. Exposure to low doses of BPA during fetal mammary gland development resulted in significant alterations in the gland's morphology that varied from subtle ones observed during the exposure period to precancerous and cancerous lesions manifested in adulthood. This study assessed the effects of BPA on fetal mammary gland development in nonhuman primates. Pregnant rhesus monkeys were fed 400 μg of BPA per kg of body weight daily from gestational day 100 to term, which resulted in 0.68 ± 0.312 ng of unconjugated BPA per mL of maternal serum, a level comparable to that found in humans. At birth, the mammary glands of female offspring were removed for morphological analysis. Morphological parameters similar to those shown to be affected in rodents exposed prenatally to BPA were measured in whole-mounted glands; estrogen receptor (ER) α and β expression were assessed in paraffin sections. Student's t tests for equality of means were used to assess differences between exposed and unexposed groups. The density of mammary buds was significantly increased in BPA-exposed monkeys, and the overall development of their mammary gland was more advanced compared with unexposed monkeys. No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents.endocrine disruptor | perinatal exposure | morphogenesis | internal dose | mammogenesis

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mentioning

confidence: 99%

Bisphenol A alters the development of the rhesus monkey mammary gland

Tharp

Maffini

Hunt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

152

View full text Add to dashboard Cite

show abstract

“…In rats high-dose BPA exposure induced changes in genes related to differentiation suggesting alterations in the normal development of the gland. The increase of undifferentiated structures and the changes in the gene expression profile at different ages suggested that prenatal exposure to BPA can affect the susceptibility of the mammary gland to transformation [131]. Gestational exposure to the estrogen-mimic BPA also altered the developing mammary glands of rhesus monkey female in a comparable manner to that observed in rodents [132].…”

Section: Bisphenol Amentioning

confidence: 81%

“…Moreover, BBP induced geneomic changes in rat mammary gland after neonatal/prepubertal exposure (post-natal days 2-20) [155]. The increase of undifferentiated structures and the changes in the gene expression profile at different ages suggested that prenatal exposure to BPA can affect the susceptibility of the mammary gland to transformation [131].…”

Section: Phthalatesmentioning

confidence: 96%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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“…This contamination is due to persistent pollution. The exposure through breastfeeding can affect the health of children in the early stages of growth [13, 14, 60]. …”

Section: Xenoestrogensmentioning

confidence: 99%

Combating Malaria with Plant Molecules: A Brief Update

Negi¹,

Gupta²,

Hamid

2013

CMC

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Observations on the role of ovarian hormones in breast cancer growth, as well as interest in contraception, stimulated research into the biology of estrogens. The identification of the classical receptors ERα and ERβ and the transmembrane receptor GPER and the resolution of the structure of the ligand bound to its receptor established the principal molecular mechanisms of estrogen action. The presence of estrogen-like compounds in many plants used in traditional medicine or ingested as food ingredients, phytoestrogens, as well as the estrogenic activities of many industrial pollutants and pesticides, xenoestrogens, have prompted investigations into their role in human health. Phyto- and xenoestrogens bind to the estrogen receptors with a lower affinity than the endogenous estrogens and can compete or substitute the hormone. Xenoestrogens, which accumulate in the body throughout life, are believed to increase breast cancer risk, especially in cases of prenatal and prepuberal exposure whereas the role of phytoestrogens is still a matter of debate. At present, the application of phytoestrogens appears to be limited to the treatment of post-menopausal symptoms in women where the production of endogenous estrogens has ceased. In this review we discuss chemistry, structure and classification, estrogen signaling and the consequences of the interactions of estrogens, phytoestrogens and xenoestrogens with their receptors, the complex interactions of endogenous and exogenous ligands, the evaluation of the health risks related to xenoestrogens, and the perspectives toward the synthesis of potent third generation selective estrogen receptor modulators (SERMs).

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Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature

Cited by 145 publications

References 76 publications

Bisphenol A alters the development of the rhesus monkey mammary gland

Bisphenol A alters the development of the rhesus monkey mammary gland

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Combating Malaria with Plant Molecules: A Brief Update

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