Effect of Premature Rupture of Membranes on Induction of Labor: A Historical Cohort Study

Abstract

Objective The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM group); the primary outcome measure was the cesarean section rate. Results The cesarean section rate for the PROM group was significantly lower (21.9% vs. 26.3%, p = 0.029). The induction-to-delivery interval was shorter (mean: 972 [854 – 6734] min vs. 1741 [97 – 10 834] min, p < 0.0001) and the rates of vaginal birth within 24 hours (80.9 vs. 52.0%, p = 0.0001) and 48 hours (98.4 vs. 85.3%, p = 0.0001) were higher in the PROM group. The impact of PROM on the cesarean section rate was not significant in multivariate analysis; however, PROM was found to have the greatest effect on the induction-to-delivery interval (p < 0.0001). Conclusion Premature rupture of membranes significantly affects various outcome measures when delivery is induced, particularly the induction-to-delivery interval.

Do we need a 200 μg misoprostol vaginal insert? A retrospective cohort study comparing the misoprostol vaginal insert to oral misoprostol

“…Protracted labor (longer than 48 h) occurred in only 4.8% as the incidence of pre‐delivery oxytocin was significantly lower (29%) compared to OM. These efficiency improvements in the MVI group were consistent in both nulliparous and parous women even though PROM was one of the most frequent indications for labor induction in the OM group which actually should lead to a shorter induction‐to‐delivery interval . Furthermore, the MVI group had a significant higher BMI than the OM group which additionally should lead to a longer time until delivery.…”

Induction of labour with sequential double-balloon catheter and oral misoprostol versus oral misoprostol alone in obese women

“…Strengths of this study are its high number of included cases and the stratification for parity which is often missing in other trials. Cases with prelabour rupture of membranes were excluded since it influences the outcome of labour induction [30].…”

Induction of Labour in Growth Restricted and Small for Gestational Age Foetuses – A Historical Cohort Study

“…Although this study is limited due its retrospective design, it nevertheless has some advantages compared to other studies. The groups in our study had clearly identifiable profiles, and cases of premature rupture of membranes or with a history of caesarean section were excluded as these factors significantly affect the success of labour induction 17 . Moreover, it again became clear that parity has a significant impact on several factors 18 .…”

“…Diese Untersuchung ist durch ihr retrospektives Design zwar limitiert, jedoch sind einige Vorteile zu anderen Arbeiten vorhanden. Die Gruppen in dieser Studie weisen ein klares Profil auf, und Fälle mit einem vorzeitigen Blasensprung oder einem Kaiserschnitt in der Anamnese wurden ausgeschlossen, da diese Faktoren den Erfolg einer Geburtseinleitung wesentlich beeinflussen 17 . Des Weiteren wird nochmals deutlich, dass die Parität einen wesentlichen Einfluss auf verschiedene Faktoren hat 18 .…”