Effect of Prednisone on Renal Function in Man

Acker, B.A.C. van; Prummel, M. F.; Weber, Julien; Wiersinga, W. M.; Arisz, L.

doi:10.1159/000187484

Cited by 26 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aloxiprin, in a dose equivalent to about 4 g salicylate, caused an average decrease of 25% in creatinine clearance and a 38% increase in plasma creatinine. GFR measured by 51 Cr-EDTA clearance remained unchanged. The authors suggested that salicylates could either disturb creatinine binding to serum proteins or competitively inhibit tubular secretion of creatinine.…”

Section: Salicylatesmentioning

confidence: 90%

“…This was explained as being a result of a reduction of urinary creatinine excretion and accumulation of plasma creatinine until a new steady state had been reached [14]. However, no concomitant changes in GFR were detected when measured by inulin [11,12], 125 I-iothalamate [13] or 51 Cr-EDTA clearances [14]. No effects of cimetidine on the assay procedure for creatinine were observed [9,12].…”

Section: Cimetidinementioning

confidence: 99%

“…Paradoxically, plasma creatinine concentration does not fall, but increases by 10% [51]. The cause of the rise in plasma creatinine is supposed to be the catabolic state with protein degeneration and loss of muscle tissue induced by the steroid treatment [51± 54].…”

Section: Other Drugs (Phenacemide Corticosteroids Vitamin D Derivatmentioning

confidence: 99%

See 2 more Smart Citations

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Andreev

Koopman

Arisz

1999

Journal of Internal Medicine

Self Cite

159

View full text Add to dashboard Cite

Abstract. Andreev E, Koopman M, Arisz L (Medical University-Sofia, Sofia, Bulgaria and University of Amsterdam, Amsterdam, The Netherlands). A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible? (Review.) J Intern Med 1999; 246: 247±252. This is a review of the available information about drugs which cause an increase in plasma creatinine concentration without decreasing glomerular filtration rate (GFR). The GFR is the main, but not the single, determinant of the plasma creatinine levels. Several drugs, such as cimetidine, trimethoprim, corticosteroids, pyrimethamine, phenacemide, salicylates and active vitamin D metabolites, have been reported to increase plasma creatinine without influencing its glomerular filtration. Cimetidine, trimethoprim, pyrimethamine and salicylates can inhibit secretion of creatinine by the proximal tubule. Corticosteroids and vitamin D metabolites probably modify the production rate and the release of creatinine. The exact mechanism of phenacemide±creatinine interaction is not fully explained. These drug-induced alterations in plasma creatinine concentration have clinical significance when GFR is estimated by using plasma creatinine.

show abstract

Section: Salicylatesmentioning

confidence: 90%

Section: Cimetidinementioning

confidence: 99%

See 1 more Smart Citation

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Andreev

Koopman

Arisz

1999

Journal of Internal Medicine

Self Cite

159

View full text Add to dashboard Cite

show abstract

“…Corticosteroides have been reported to increase GFR nonspecifically [6] but nevertheless the creatinine concentration increased by 10% [7]. This increase in creatinine is attributed to the catabolic state with protein degeneration and loss of muscle tissue induced by the steroid treatment [2].…”

Section: Exogenous Substancesmentioning

confidence: 99%

Positive and negative false estimates of serum creatinine

Nigam¹,

Ch²,

'³

2017

Interventional-Cardiology.

View full text Add to dashboard Cite

Accurate and precise measurement of serum creatinine is very important for assessment of kidney function. However, false estimates of serum creatinine have been found due to interference by both exogenous and endogenous substances which have been attributed to factors such as decreased or inhibited tubular secretion of creatinine, interference with serum creatinine assays and increased production of creatinine. Several drugs cause positive and negative interference through these mechanisms resulting in false positive and negative estimates of serum creatinine which may affect glomerular filtration rate (GFR) calculation also. Endogenous substances also affect the creatinine assay systems resulting in false estimate of serum creatinine concentration. Therefore, the awareness about the drug-induced or endogenous substance-induced false estimates of serum creatinine and preanalytical errors in blood sampling is important. Some remedial measures to avoid these interferences are: (i) avoiding blood draws from indwelling catheter, (ii) giving preference to fasting blood specimen and (iii) selecting the suitable analytical method for creatinine estimation (based on the information about the drugs being given to the concerned patient).

show abstract

“…Glucocorticoid therapy has been reported to be associated with increased GFR, and paradoxically, increased creatinine and cystatin C concentrations [22,23,37]. While glucocorticoid therapy is not known to affect gentamicin clearance [38], an increase in GFR associated with such …”

Section: Figurementioning

confidence: 99%

The performance of contemporary cystatin C‐based GFR equations in predicting gentamicin clearance

Chin

Chew-Harris

Florkowski

et al. 2015

Brit J Clinical Pharma

View full text Add to dashboard Cite

AIMSWe aimed to compare the performances of contemporary cystatin C (Cys)-based GFR equations, and the creatinine only Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for predicting gentamicin clearance. METHODSThe bias and imprecision of the CKD-EPI, CKD-EPI_Cys and creatinine-cystatin C CKD-EPI (CKD-EPI_CrCys) equations for predicting gentamicin clearances, were assessed in 260 patients treated with gentamicin during 2012-2013. The creatinine-cystatin C Berlin Initiative Study equation (BIS_CrCys) was examined in the ≥70 year subgroup. The reference gentamicin clearance was calculated using post-dose plasma concentrations. RESULTSThe CKD-EPI_CrCys equation had the highest percentage of estimates within 30% of the reference gentamicin clearance (70%, P = 0.003) and lowest root mean square error (95% CI) of 29 (25, 23) ml min −1 of the three equations for the entire cohort. There was no significant improvement in the performances of the equations with the exclusion of 41 patients with abnormal thyroid function tests or steroid co-prescription at the time of the index gentamicin dose. Of the remaining 219 patients, adjustment for individual BSA improved the performances of all GFR equations (P ≤ 0.003) in those with body mass indices (BMI) <18.5 or ≥30 kg m CONCLUSIONSThe CKD-EPI_CrCys equation provided the best estimate of gentamicin clearance. If used for guiding gentamicin dosing, the results from GFR equations should be adjusted for individual BSA at the extremes of body size.

show abstract

Effect of Prednisone on Renal Function in Man

Cited by 26 publications

References 13 publications

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?

Positive and negative false estimates of serum creatinine

The performance of contemporary cystatin C‐based GFR equations in predicting gentamicin clearance

Contact Info

Product

Resources

About