Effect of precursors on biosynthesis of monensins A and B

Abstract

Precursors of monensins (acetate, propionate, butyrate, isobutyrate) affect the total production and the relative proportion of monensins A and B. Addition of propionate into the fermentation medium causes a prevalence of monensin B whereas butyrate and isobutyrate stimulate the production of monensin A and suppress the production of monensin B.

Influence on dithiolopyrrolone antibiotic production by organic acids in Saccharothrix algeriensis NRRL B-24137

“…These organic acids are used directly as precursors in the biosynthesis of TIP and BUP, and it is reasonable that they are formed selectively in the presence of these organic acids. These results are similar to those found by many authors who reported that the production of monensins A and B by S. cinnamonensis, APHE-1 and APHE-2 by S. griseocarneus, erythromycin by S. erythreus and spiramycin by S. ambofaciens is induced by propionate and butyrate as precursors [12,15,17,18].…”

Liquid culture carbon, nitrogen and inorganic phosphate source regulate nematicidal activity by fluorescent pseudomonads in vitro

“…Whereas acetate did not have an apparent influence on the antagonistic behaviour of the two bacteria, propionate strongly enhanced the nematicidal potential of IE-6S + and CHA0. The presence of both short fatty acid precursors in the medium not only influences the cellular composition of the fatty acids (Kaneda 1963), but they are also used directly in the biosynthesis of secondary metabolites by bacteria (Pospíšil et al 1985). The presence of different concentrations of Pi in MM medium demonstrates distinct requirements for the optimal nematicidal activity of Ps.…”