Effect of pre-treatment with St John's Wort on nephrotoxicity of cisplatin in rats

Shibayama, Yoshihiko; Kawachi, Asuka; Onimaru, Shunji; Tokunaga, Jin; Ikeda, Ryuji; Nishida, Kazuhiro; Kuchiiwa, Satoshi; Nakagawa, Shiro; Takamura, Norito; Motoya, Toshiro; Takeda, Yasuo; Yamada, Katsushi

doi:10.1016/j.lfs.2007.04.025

Cited by 15 publications

(8 citation statements)

References 27 publications

(28 reference statements)

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“…However; our results on biochemical analysis, revealed the role of free radicals in the induction of the observed genotoxicity appears to be mediated through the reactive oxygen species. Our results are supported by recent studies, which have drawn a clear relation between the genesis of free radicals and the induction of genotoxicity [54, 55] Nevertheless, these data contradicts the literature reports on different extracts of SJW and a large number of constituents (terpenes, sesquiterpenes, tannins and flavonoids (quercetin and biflavones) of SJW, that are found to be antioxidants and known to protect against genotoxicity and/or carcinogenicity [56–62]. The discordance in these results might be due to the redox state of the cells and the pre-loading of SJWS much before the exposure of the tissues to oxidant injury.…”

Section: Discussionsupporting

confidence: 75%

Cytological and Biochemical Effects of St. John’s Wort Supplement (A Complex Mixture of St. John’s Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino Mice

Aleisa

2008

IJERPH

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Commercially available St. John’s wort supplement (SJWS) composed of an herbal mixture of St. John’s Wort (SJW), Rosemary (RM) and Spirulina (SP) is used as a dietary supplement for the treatment of psychiatric disorders. Although the minor ingredients, (RM and SP) are proven antioxidants, their quantity is quite insignificant as compared to the SJW, which is the major ingredient. Most of the toxic effects of SJWS are attributed to the main constituents of SJW which differ due to the influence of light (hypericin) and variations in temperature above freezing point (hyperforin). However, there are no reports on toxicity of SJWS maintained at room temperature in pharmacies and supermarkets. In view of the folkloric importance, immense (prescribed or unprescribed) use and a paucity of literature on SJWS, it was found worthwhile to (1) determine the genotoxic effects of SJWS in somatic and germ cells of mice and (2) investigate the role of biochemical changes, as a possible mechanism. The protocol included the oral treatment of mice with different doses (380, 760 and 1520 mg/kg/day) of SJWS for 7 days. The following experiments were conducted: (i) cytological studies on micronucleus test, (ii) cytogenetic analysis for meiotic chromosomes, (iii) cytological analysis of spermatozoa abnormalities, (iv) quantification of proteins and nucleic acids in hepatic and testicular cells and (v) estimation of malondialdehyde (MDA) and nonprotein sulfhydryl (NP-SH) in hepatic and testicular cells. The treatment increased the frequency of micronuclei in polychromatic erythrocytes (PCE) in the femora. It caused aberrations in chromosomes of testes and induced spermatozoa abnormalities. These changes might be attributed to the epigenetic mechanisms as revealed by an increase in concentrations of MDA and depletion of nucleic acids and NP-SH levels in both hepatic and testicular cells observed in the present study. Since, the samples of SJWS used were not drawn from extremities of light and temperature; the observed effect might not be related to the main constituents of SJW. However, these changes might be ascribed to the combined effect of terpenes, tannins, quercetin and flavonoids present in SJW.

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Section: Discussionsupporting

confidence: 75%

Cytological and Biochemical Effects of St. John’s Wort Supplement (A Complex Mixture of St. John’s Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino Mice

Aleisa

2008

IJERPH

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“…The ability of MTs to bind with gold and platinum [70] and the role of these proteins in the maintenance of homeostasis of zinc and copper have been taken into account [71]. In vitro studies have shown that apometalloproteins play the role of donors of zinc and copper ions.…”

Section: Mts As Factors Responsible For Protection Against Free-radicmentioning

confidence: 99%

Peculiarities of the Molecular Structure and Functions of Metallothioneins in the Central Nervous System

Ушакова

Kruchinenko

2009

Neurophysiology

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This review presents modern concepts on the structure and principles of classification of low-molecularweight proteins capable of binding with metal ions, metallothioneins (MTs). The mechanism underlying the binding of metals with these biopolymers is characterized; the main functions of MTs in the CNS, their role in defense reactions of neurons and other cells, as well as of those of the organism in general are reviewed.

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“…Cette plante est capable de réduire la gravité des signes d'arrêt de la nicotine chez la souris [8], elle induit une diminution de la créatinine sérique et bloque dans la majorité des cas les dommages tubulaires causés par le cisplatine responsable d'une néphrotoxicité [52].…”

Section: Pharmacologieunclassified

Notes ethnobotanique et phytopharmacologique de Hypericum perforatum L.

Rammal¹,

Bouayed²,

Desor³

et al. 2009

Phytothérapie

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Effect of pre-treatment with St John's Wort on nephrotoxicity of cisplatin in rats

Cited by 15 publications

References 27 publications

Cytological and Biochemical Effects of St. John’s Wort Supplement (A Complex Mixture of St. John’s Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino Mice

Cytological and Biochemical Effects of St. John’s Wort Supplement (A Complex Mixture of St. John’s Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino Mice

Peculiarities of the Molecular Structure and Functions of Metallothioneins in the Central Nervous System

Notes ethnobotanique et phytopharmacologique de Hypericum perforatum L.

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