Effect of Pre-Treatment With Lysine Acetyl Salicylate on Suxamethonium-Induced Myalgia

Abstract

The hypothesis that prostaglandin inhibitors might reduce the incidence and severity of suxamethonium-induced myalgia was investigated using lysine acetyl salicylate (LAS) 13 mg kg-1 i.v. 3 min before the administration of suxamethonium in 20 patients. A comparison was made with atracurium 0.09 mg kg-1 (and placebo) in a double-blind prospective randomized trial. LAS and atracurium were effective in reducing the incidence and severity of postsuxamethonium myalgia and the increases in serum potassium concentration. There were no appreciable changes in serum calcium, sodium, chloride, phosphate, magnesium, creatinine, creatine phosphokinase concentrations or plasmacholinesterase activity. Atracurium caused a delay in the onset of action and a decrease in the intensity of suxamethonium-induced neuromuscular block. It is concluded that LAS pretreatment might have a place in suitable patients in the prevention of suxamethonium-induced myalgia and increases in serum potassium concentration.

Succinylcholine‐associated postoperative myalgia

“…There is some evidence that prostaglandin inhibitors reduce the incidence and severity of succinylcholine‐induced myalgia [61]. There may be parallels between the calcium influx seen after succinylcholine and that observed in experimentally induced muscle damage.…”

Intubation Conditions and Postoperative Myalgia in Outpatient Dental Surgery: A Comparison of Succinylcholine with Mivacurium

“…NDNMBs can produce a reduction in myalgia occurrence by an average of 30% 5 although up to 70% reduction has been reported 16 . Although non-depolarizing agents are not usually associated with myalgia, a similar incidence of myalgia for succinylcholine, with precurarization, and vecuronium 17 has been shown following laparoscopic surgery.…”

Precurarization

“…Modalities which have been shown to reduce fasciculations may not reduce the incidence of POM, 21 while therapies which reduce pain may not "defasciculate" patients. 22 In an electromyographic study, Collier 23 could not find a relationship between the vigour or duration of visible fasciculations and POM, but discovered that patients whose fasciculation discharge frequency rates were > 50 Hz had a very high rate of POM. The severity of pain was not directly related to the discharge rate but, as he stated, "the occurrence of symptoms was an 'allor-none' response above a certain threshold frequency."…”