Effect of Pre-Operative Oral Melatonin on Pre-Operative Anxiety and Post-Operative Pain Score in Patients Undergoing Laproscopic Surgeries

Abstract

Introduction: Preoperative anxiety may cause hemodynamic problems in the intraoperative period, increased analgesic need, and lower postoperative satisfaction of the patients. Melatonin has anxiolytic, sedative and potential analgesic effects when used as premedication before surgery. After institutional ethical committee clearance and patient Materials and methods: s informed written consent, 100 ASA 1 and 2 patients aged between 18 to 65 years posted for laparoscopic surgeries under GA were randomized into M and P groups with 50 in each. All patients received either 6mg oral melatonin dissolved in 3ml distilled water in melatonin group or 3ml distilled water in placebo group one hour before surgery. APAIS anxiety scale was measured before and one hour after premedication. Post operatively RSS scale for sedation and NRS scale for pain were measured at 30 min, 60 min, 90min, 120min in post anaesthetic care unit. The time of rst rescue analgesia was noted. APAIS anxiety Results: scores determined prior to administration of medications showed non-signicant differences between the groups (11.9 SD 1.3 in melatonin group, 11.8 SD 1.6 in placebo/control group). APAIS anxiety scores determined at one hour after receiving the study medication were decreased more signicantly in melatonin group than in control group with p value of 0.0005 (3.5 SD 1.1 in melatonin group, 7.5 SD 1.2 in placebo/control group). Postoperatively RSS scores showed better sedation in Melatonin group than in Placebo group. Pain scores were less in melatonin group than in placebo group. The time for rst request of rescue analgesia was delayed in melatonin group than in placebo. Preoperative oral Conclusion: melatonin 6mg reduces preoperative anxiety, postoperative pain and analgesia requirement.