Effect of pre-exchange albumin infusion on neonatal hyperbilirubinaemia and long-term developmental outcomes

Xiong, Tao; Chen, Hongju; Mu, Dezhi

doi:10.1002/14651858.cd011001

Cited by 1 publication

(2 citation statements)

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“…Phototherapy is popular for the treatment of neonatal hyperbilirubinemia, and occasionally in combination with IVIG and IVALB infusion for severe cases (6,9,16). IVIG and/or IVALB are effective for neonates with hemolytic hyperbilirubinemia and for preventing neurodevelopmental abnor malities or ker nicter us.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, intravenous immunoglobulin (IVIG) and albumin (IVALB) are administrated to neonates with hemolytic hyperbilirubinemia (4,5). IVALB may be effective for preventing the occurrence of complications associated with hyperbilirubinemia, including neuronal developmental abnormalities and blood transfusions (6)(7)(8)(9). However, there have been a number of previous studies indicating that neonatal hyperbilirubinemia and/or phototherapy may be associated with infant immune disorders including asthma, thrombocytopenia and arthritis (10)(11)(12), or septic shock (13,14).…”

Section: Introductionmentioning

confidence: 99%

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Phototherapy is associated with the decrease in serum globulin levels in neonatal hyperbilirubinemia

et al. 2018

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Previous studies have indicated that phototherapy may be associated with childhood immune disorders in later life. The present study aimed to assess the effects of phototherapy as a risk factor in the decrease in serum globulin (GLB) levels during neonatal hyperbilirubinemia. A total of 430 full-term infants aged between 1 and 28 days, diagnosed with neonatal hyperbilirubinemia, were enrolled in the present study. Neonates with intrauterine infection, genetic abnormalities and congenital diseases were excluded from the cohort. All neonates received single-side phototherapy (halogen lamps for 12 h per day, for 3 days) and/or intravenous albumin (IVALB; 1 g/kg/day, for 2 days) and/or intravenous immunoglobulin (1 g/kg/day, for 2 days). Total serum bilirubin (TSB), albumin (ALB) and GLB levels were examined twice, on the first and fourth days of hospitalization. Neonatal TSB concentrations decreased from 299.6±83.9 to 163.6±57.6 µmol/l following 3 days of intensive treatment (P<0.001). Pearson correlative analysis indicated that TSB was significantly correlated to the GLB level (r=0.249; P<0.01), but not with ALB level. There was a significant decrease in GLB levels following phototherapy+IVALB (P<0.001). The GLB levels decreased to 2-4 g/l (10-20% compared with their baseline levels) and were markedly decreased in infants >16 days old compared with those in patients aged <16 days (P<0.001). The decreases in GLB levels observed were 21.3±4.1 to 18.5±4.2 g/l in the phototherapy group, and 23.0±3.9 to 16.6±4.5 g/l in the phototherapy+IVALB (P<0.001). The decrease in GLB levels was associated with age (95% confidence interval;-0.152,-0.016). The results demonstrated that phototherapy decreased serum GLB levels, particularly in infants aged >16 days, while additional IVALB treatment promoted the decrease, along with increased age.

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Section: Discussionmentioning

confidence: 99%