Effect of pre-emptive pregabalin on pain intensity and postoperative morphine consumption after laparoscopic cholecystectomy

Abstract

Administration of 600 mg pregabalin per os, divided in two preoperative doses, significantly reduces postoperative pain as well as opioid consumption in patients undergoing laparoscopic cholecystectomy, at the cost of increased incidence of dizziness.

Pre-Emptive oral Pregabalin for Pain Relief After Laparoscopic Cholecystectomy

“…Chang et al [12] had also showed that pain scores, time for first rescue analgesia and additional need of ketolorac consumption did not differ significantly in pregabalin vs placebo. This is in contrast to other studies by Agarwal, Balaban, Sarakatsianou and Singh et al [7][8][9][10]. Bekawi et al had reported very different results than all previous studies [13].…”

“…Similarly, Balaban et al [8] showed decrease in pain scores with pregabalin 150 and 300 mg compared to placebo. Sarakatsianou in 2013 [9] demonstrated similar reduction in pain scores with 300 mg pregabalin administered twice before surgery. Singh et al in 2016 [10] also showed efficacy of 150 and 300 mg pregabalin in decreasing pain scores.…”

“…Balaban et al, Chang et al, Esmat et al and Girija et al reported increased postoperative sedation early (at 15 min and 2 h, respectively) in the intervention group (300 mg PG) [8,12,16,17]. Sarakatsianou had reported an increase in incidence of dizziness which was significantly higher in the PG group during the first 8 hours postoperatively and occurred in 70% of patients [9]. Patients receiving pregabalin exhibited a significant extubation time delay.…”

Preemptive Single-Dose Pregabalin in Modulation of Postoperative Pain and Opioid Requirement After Laparoscopic Cholecystectomy- A Randomized Clinical Study

“…Moreover, the number of patients receiving rescue analgesic at various time intervals was found to be significantly less in pregabalin group compared to placebo group. Findings similar to our study are further supported by individual studies by Agarwal A et al (2008), 8 Balaban F et al (2012), 23 Sarakatsianou et al (2013) 24 and Singh TH et al (2014). 18 This is in contrast to a study by Peng et al (2010) 13 where they found that although 50 and 75 mg oral pregabalin were able to decrease pain scores in patients undergoing laparoscopic cholecystectomy, analgesic requirement in the form of fentanyl was not decreased.…”

The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial

“…Previous studies have investigated the effectiveness of either pregabalin or celecoxib alone as a modifier of pain scores and opioid usage in laparoscopic surgery [14,[27][28][29][30][31][32][33][34][35][36][37][38][39]. Studies investigating celecoxib alone in laparoscopic surgery have generally shown positive results in decreasing pain intensity and opioid requirements postoperatively [27][28][29].…”