Effect of Pravastatin on Progression of Coronary Atherosclerosis in Patients After Coronary Artery Bypass Surgery Pravastatin Coronary Artery Bypass Graft Study

Intensive LOwering of BlOod pressure and low-density lipoprotein ChOlesterol with statin theraPy (LOBOCOP) may improve neointimal formation after coronary stenting in patients with coronary artery disease

“…We also reported earlier that lowering the level of LDL-C ( < 80 mg/dl) by statin prevents the progression of coronary restenosis after stent implantation in patients with acute myocardial infarction [5]. Although statin therapy was associated with reduced restenosis after successful coronary stent implantation [6] and coronary artery bypass surgery [7], it is still unclear whether statins help to prevent coronary restenosis. In addition, stent implantation also provides a useful model for assessing the potential interrelation among serum evidence of inflammation, statin therapy, and the progression of atherosclerotic disease, which is primarily determined by neointima formation.…”

Do Valsartan and Losartan Have the Same Effects in the Treatment of Coronary Artery Disease?

“…When patients were not treated with a statin, the differential effect was remarkable. Because statin therapy is associated with preventing coronary restenosis, 20,21 statin treatment may negate the difference between valsartan and losartan.…”

Treatment - Drug Therapy

“…As for evidence of secondary prevention in a Japanese population evaluating the regression of coronary atherosclerosis by coronary angiography, LDL-C-lowering therapy was reported to prevent the progression of coronary atherosclerosis similarly to overseas studies 48,49) . Among intervention studies using IVUS, the one by Takagi et al was reported first in the world 50) , showing prevention of the progression of coronary atherosclerosis.…”