Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats

Andrade, Paulo Henrique Muleta; Portugal, Luciane Canderolo; Rondon, Eric Schmidt; Toffoli-Kadri, Mônica Cristina; Matos, Maria de Fátima Cepa

doi:10.1590/s0102-865020180020000010

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…53 Although many other topical biological therapies and dressings are beneficial in wound healing in general such as collagen, hyaluronan, powdered shells, plant oils, and amniotic membrane, more clinical trials in ischemic wound are needed before any solid conclusion can be drawn. [118][119][120][121][122][123][124] Topical administration of exogenous biologic agents has potential safety and low-risk therapy. PRP therapy and 4 growth factors have shown the greatest potential in clinical trials, including PDGF, EGF, FGF, and VEGF.…”

Section: Discussionmentioning

confidence: 99%

Role of Topical Biological Therapies and Dressings in Healing Ischemic Wounds

Orrapin

Rekasem

2018

The International Journal of Lower Extremity Wounds

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Ischemic wounds are the most severe expression of critical limb ischemia (CLI), and they have been defined clinically as an end stage of peripheral arterial disease. Urgent revascularization is a fundamental part for limb salvage in patients with CLI. However, the risk of revascularization should be weighed against the likelihood of success given a patient's life-threatening comorbidities. Once the condition of arterial insufficiency is revascularized, wound care is an important aspect to promote the wound healing process and infection control. MOIST concept for wound care is a modern systematic treatment for enhanced wound healing process. Currently, advanced biological therapies are emerging in ischemic wound therapies to restore the wound healing process and involve active biological agents to support the wound healing process. We studied and summarized the different types of available topical biological therapies and their mechanisms on the healing process including platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, and vascular endothelial growth factor, platelet-rich plasma, and honey for local wound care of patient with CLI. Our review suggests that topical plateletderived growth factor, epidermal growth factor, platelet-rich plasma, and honey are available as well as considered in the ischemic wound healing process enhancement through the MOIST concept. In conclusion, biologic wound dressing or topical agent therapy may improve the wound healing process, increase limb salvage, is inexpensive, and provides potential safety with nontoxic low-risk therapy in patients with an ischemic wound. Thus, local wound care by biological dressing should be added in adjuvant treatment for ischemic wound patients. However, further randomized studies are needed to support efficacy and long-term outcomes of these biological dressing in patients with ischemic wound.

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Section: Discussionmentioning

confidence: 99%

Role of Topical Biological Therapies and Dressings in Healing Ischemic Wounds

Orrapin

Rekasem

2018

The International Journal of Lower Extremity Wounds

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“…These findings indicate the potential medical applications of these matrix proteins or their extracts, specifically for treating various skin conditions and promoting wound healing. Indeed, a study conducted on live rats with dorsal skin wounds shown that the gradual application of an ointment comprising powdered shells of Megalobulimus lopesi resulted in a reduction of the wound [ 89 ].…”

Section: Adhesive/extracellular Matrix Proteinsmentioning

confidence: 99%

Bridging Nature and Engineering: Protein-Derived Materials for Bio-Inspired Applications

Nawaz,

Gu,

Gibbons

et al. 2024

Biomimetics

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The sophisticated, elegant protein-polymers designed by nature can serve as inspiration to redesign and biomanufacture protein-based materials using synthetic biology. Historically, petro-based polymeric materials have dominated industrial activities, consequently transforming our way of living. While this benefits humans, the fabrication and disposal of these materials causes environmental sustainability challenges. Fortunately, protein-based biopolymers can compete with and potentially surpass the performance of petro-based polymers because they can be biologically produced and degraded in an environmentally friendly fashion. This paper reviews four groups of protein-based polymers, including fibrous proteins (collagen, silk fibroin, fibrillin, and keratin), elastomeric proteins (elastin, resilin, and wheat glutenin), adhesive/matrix proteins (spongin and conchiolin), and cyanophycin. We discuss the connection between protein sequence, structure, function, and biomimetic applications. Protein engineering techniques, such as directed evolution and rational design, can be used to improve the functionality of natural protein-based materials. For example, the inclusion of specific protein domains, particularly those observed in structural proteins, such as silk and collagen, enables the creation of novel biomimetic materials with exceptional mechanical properties and adaptability. This review also discusses recent advancements in the production and application of new protein-based materials through the approach of synthetic biology combined biomimetics, providing insight for future research and development of cutting-edge bio-inspired products. Protein-based polymers that utilize nature’s designs as a base, then modified by advancements at the intersection of biology and engineering, may provide mankind with more sustainable products.

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