Effect of powder characteristics on oral tablet disintegration

Yamamoto, Yoshihiko; Fujii, Makiko; Watanabe, Kenji; Tsukamoto, Masashi; Shibata, Yusuke; Kondoh, Masuo; Watanabe, Yoshihisa

doi:10.1016/j.ijpharm.2008.08.031

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…Therefore, ease of administration of dosage forms is of paramount importance, especially amongst certain Alzheimer's disease patients who tend to be even less cooperative (4). In recent years, various novel drug delivery systems have been developed to improve patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease

2011

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Abstract. The aim of this study was to develop a taste-masked oral disintegrating film (ODF) containing donepezil, with fast disintegration time and suitable mechanical strength, for the treatment of Alzheimer's disease. Hydroxypropyl methylcellulose, corn starch, polyethylene glycol, lactose monohydrate and crosspovidone served as the hydrophilic polymeric bases of the ODF. The uniformity, in vitro disintegration time, drug release and the folding endurance of the ODF were examined. The in vitro results showed that 80% of donepezil hydrochloride was released within 5 minutes with mean disintegration time of 44 seconds. The result of the film flexibility test showed that the number of folding time to crack the film was 40 times, an indication of sufficient mechanical property for patient use. A single-dose, fasting, four-period, eight-treatment, double-blind study involving 16 healthy adult volunteers was performed to evaluate the in situ disintegration time and palatability of ODF. Five parameters, namely taste, aftertaste, mouthfeel, ease of handling and acceptance were evaluated. The mean in situ disintegration time of ODF was 49 seconds. ODF containing 7 mg of sucralose were more superior than saccharin and aspartame in terms of taste, aftertaste, mouthfeel and acceptance. Furthermore, the ODF was stable for at least 6 months when stored at 40°C and 75% relative humidity.

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Section: Introductionmentioning

confidence: 99%

Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease

2011

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“…These parameters can be classified in four different categories related to (i) the SD itself, (ii) the formulation components, (iii) the compaction process, and (iv) the physicochemical environment of the SD during the disintegration. SD parameters such as distribution and concentration in the tablet (5), particle granulometry, mixed powders' bulk density, compression mode, and the resulting tablet porosity are all parameters which have shown to influence the disintegration efficacy (6)(7)(8)(9), as well as the solubility, the hydrophilic nature of the formulation components, and the pH of the disintegrating medium (7,10,11). Even if these previous studies show an influence of the formulation on the disintegration processes, there is still lacking explanation on the physicochemical phenomena that explain the influence of the formulation on the disintegration processes.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, we formulated tablets with different mannitol concentrations and evaluated their disintegration time. The choice of this excipient is in relation to its extensive use in formulation for direct compression and orally disintegrating tablets (8,14) as well as its ability to change the relative permittivity of aqueous medium in which it is dissolved (15,16).…”

Section: Introductionmentioning

confidence: 99%

Impact of Physicochemical Environment on the Super Disintegrant Functionality of Cross-Linked Carboxymethyl Sodium Starch: Insight on Formulation Precautions

et al. 2014

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Abstract. The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior and properties of this SD (medium uptake, disintegration times, particle size, and rheology) was investigated in a wetting medium of different physicochemical properties. In particular, the relative permittivity (dielectric constant) of these media was intentionally modified for evaluating its effect on CCSS properties. Results showed different swelling behaviors of CCSS particles according to the relative permittivity of the tested media and allow to propose two underlying mechanisms that explain CCSS functionality. Both the intra-particular swelling and the inter-particular repulsion are affected by the relative permittivity of the media. Finally, disintegration test performed on tablets specially formulated with mannitol (used commonly as an excipient and known to modify relative permittivity) confirmed that the functionality of CCSS and therefore the disintegration of the tablet can be altered according to the mannitol content.

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“…The direct compression method is advantageous due to its simplicity of combining blended ingredients and pressing them into a tablet without having to change the formulation or ingredients and, simultaneously, the forces generated during compression may be used to understand the roll compaction mechanisms (Yusof et al, 2005). The study and application of the powder compression process has continued to develop in line with the needs of the pharmaceutical (Varthalis and Pilpel, 1976;Mohammed et al, 2006;Yamamoto et al, 2009), food (Yusof et al, 2005), and herbal industries (Eggelkraut-Gottanka et al, 2002;Schiller et al, 2003). The characteristics and performance of tropical herbal powder extracts during direct compression are neither well documented nor understood.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Direct Compression Characteristics of Andrographis paniculata, Eurycoma longifolia Jack, and Orthosiphon stamineus Extracts for Tablet Development

Yusof¹,

Hamid²,

Ahmad³

et al. 2011

New Tribological Ways

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Effect of powder characteristics on oral tablet disintegration

Cited by 18 publications

References 8 publications

Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease

Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease

Impact of Physicochemical Environment on the Super Disintegrant Functionality of Cross-Linked Carboxymethyl Sodium Starch: Insight on Formulation Precautions

A Comparison of the Direct Compression Characteristics of Andrographis paniculata, Eurycoma longifolia Jack, and Orthosiphon stamineus Extracts for Tablet Development

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