Effect of potassium and norepinephrine on the tone of the isolated artery: Changes by ouabain pretreatment

Gebert, G; Piechowiak, H

doi:10.1007/bf01921588

Cited by 25 publications

(14 citation statements)

References 12 publications

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“…The ACh-stimulated artery strips also showed this tendency, although the mean control tensions in the different K + concentrations were not significantly different. This relationship between [K + ] and control tension in this study is consistent with the biphasic response of many isolated arterial preparations to a step increase in [K + ] from a low level within the 2.0-10.0 mM range (Biamino and Wessel, 1973;Gebert and Piechowiak, 1974;Gellai and Detar, 1974;Konold et al, 1968 (Figs. 3 and 6).…”

Section: Discussionsupporting

confidence: 70%

Interactions of vasoactive effects of adenosine and potassium ion on isolated feline coronary artery smooth muscle.

Foley

Amsterdam²,

Mason

1979

Circulation Research

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207Middleton S, Oberti C, Prager R, Middleton HH: Stimulating effect of acetylcholine on the papillary myocardium. Acta Physiol Lat ] on isolated coronary artery smooth muscle. Helical strips of cat coronary arteries, suspended in physiologic salt solution (37 °C, 95% Oi, and 5% COi) were used. In some experiments, isometric tension was induced by acetylcholine (ACh), while in others, spontaneously contracting strips were studied. In the first series of experiments, equilibration of artery strips in solutions of increasing ] induced an additional relaxation of 29.7 ± 4.6%, which was significantly greater than the relaxation in the absence of adenosine (P < 0.005). Simultaneous addition of potassium and adenosine produced significantly greater relaxation than either substance individually. The latter two findings support the concept that vasoactive agents may interact to relax arterial smooth muscle. These results may have implications with regard to local regulation of coronary blood flow.

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Section: Discussionsupporting

confidence: 70%

Interactions of vasoactive effects of adenosine and potassium ion on isolated feline coronary artery smooth muscle.

Foley

Amsterdam²,

Mason

1979

Circulation Research

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“…64 Whether the inhibitor of sodium transport found in persons with essential hypertension affects sodium transport in arteriolar smooth muscle is not known. Ouabain increases the reactivity of isolated arteries to agonists such as norepinephrine, 65 " 67 and oral digoxin for4 days in normotensive subjects increased the blood pressure response to both infused norepinephrine and infused angiotensin II. 68 Whether this is a direct effect on arteriolar smooth muscle cells or is mediated by the sympathetic nervous system is not known.…”

Section: Abnormalities Of Sodium Metabolism In Humanmentioning

confidence: 98%

Sodium is more important than calcium in essential hypertension.

Macgregor¹

1985

Hypertension

168

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There is much circumstantial and some direct evidence in humans to suggest that a high consumption of salt predisposes communities and individuals to the development of essential hypertension. Recent work has suggested possible mechanisms whereby a high salt intake could cause a rise in blood pressure in genetically susceptible persons. Restriction of salt intake in the diet lowers blood pressure in many subjects with high blood pressure and this fall in blood pressure is mediated in part by a diminished renin response to sodium restriction as hypertension develops. The effect of sodium restriction, like diuretics, is additive to most blood pressure lowering drugs, particularly those that inhibit the renin system such as beta-blockers and angiotensin converting enzyme inhibitors. Claims that a slight reduction in calcium intake may be important in the development of high blood pressure are disputed. Furthermore, no satisfactory hypothesis has been put forward to explain how a small reduction in dietary calcium intake could cause high blood pressure. Large increases in calcium intake have been reported to lower blood pressure in both normotensive and hypertensive humans. The three published studies, however, are not in agreement.

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“…The net effect of potassium on the smooth muscle cell has, in fact, been interpreted quantitatively as the sum of opposing actions of the ion (27,30,39). In support of this concept is the fact that the vascular smooth muscle relaxation induced by potassium can be eliminated or converted to a constriction by the administration of ouabain (10,12,25). Furthermore, at least part of the apparent differences among various tissues and preparations seems to be due to the experimental conditions used, since in some preparations consistent smooth muscle relaxations can be induced by potassium in in vitro preparations only when the tissues are incubated in 2 mM K + (27,31).…”

Section: Dulingmentioning

confidence: 99%

“…Many investigators have shown that potassium at the increased concentrations observed in venous blood during exercise and hypoxia can relax smooth muscle both in vivo (5)(6)(7)(8)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and in vitro (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Therefore, this ion.…”

mentioning

confidence: 99%

Effects of potassium ion on the microcirculation of the hamster.

Duling¹

1975

Circulation Research

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The vasoactive properties of potassium were assessed in the microcirculation of the hamster cremaster muscle and the muscular and epithelial portions of the hamster cheek pouch. Tissues were transilluminated and suffused with a physiological salt solution whose potassium concentration varied from 0 to 20 mM. Vessel diameters were measured and normalized as a percent of the control diameter (± SE) observed during exposure to 4.7 mM K + . Altering the potassium concentration in the suffusion solution caused a transient vascular response. The peak changes in the vascular diameter of the arterioles supplying striated muscle varied directly with the suffusion solution potassium concentration from a minimum of 78 ± 3% in 0 mM K + to 155 ± 15% in 15 mM K". Vascular diameter increases were sustained for the full 5-minute test period only in 15 mM K+. In the epithelial portions of the cheek pouch, only the constrictor component of the potassium response was observed. The data indicate that potassium is sufficiently potent to participate in initiating functional hyperemia in striated muscle and might cause as much as a 6.3-fold increase in flow. Functional hyperemias exceeding approximately 3 minutes cannot be due to potassium ion, since the dilation induced by this agent is transient.• Cells contain a large store of labile potassium that can be released by various stimuli such as muscle contraction and hypoxia (1-9). Many investigators have shown that potassium at the increased concentrations observed in venous blood during exercise and hypoxia can relax smooth muscle both in vivo (5)(6)(7)(8)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and in vitro (21-31). Therefore, this ion. may be important in the local control of blood flow. However, further quantification of the reactivity of resistance vessels to the ion must be carried out before accurate estimates of the importance of potassium in blood flow regulation can be made. These data can be obtained by studying microvessel responses to alterations in suffusion solution potassium concentrations, but such experiments have only been performed on pial vessels (11,16,17). Furthermore, no data are currently available showing the temporal response pattern of microvessels during variations in potassium concentration. These data are of particular interest in view of the transient potassium ion release during functional hyperemia in striated muscle (7,8) and the transient vascular smooth muscle response to potassium both in vitro (26-32) and in vivo (10). A preliminary report of this work was presented at the Fall Meeting of the American Physiological Society, August, 1974. This work was done during Dr. Duling's tenure as an Established Investigator of the American Heart Association.Received September 20, 1974. Accepted for publication June 4, 1975. I have therefore studied the responses of the arterioles of the hamster cremaster muscle and cheek pouch to changes in the potassium concentration of a superfusion solution. The aims of the experiment were to: (1) estab...

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Effect of potassium and norepinephrine on the tone of the isolated artery: Changes by ouabain pretreatment

Cited by 25 publications

References 12 publications

Interactions of vasoactive effects of adenosine and potassium ion on isolated feline coronary artery smooth muscle.

Interactions of vasoactive effects of adenosine and potassium ion on isolated feline coronary artery smooth muscle.

Sodium is more important than calcium in essential hypertension.

Effects of potassium ion on the microcirculation of the hamster.

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