Effect of postconditioning on infarction size, adverse left ventricular remodeling, and improvement in left ventricular systolic function in patients with first anterior ST‑segment elevation myocardial infarction

Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials

“…Death and heart failure events were observed in all studies, and non-fatal reinfarction, TVR, stent thrombosis, and angina events were analyzed in six, five, four, and four trials, respectively (Table 3). The detailed information about outcomes of four trials was acquired by sending e-mails to the first author (Lønborg et al, 2010a;2010b;Elżbieciak et al, 2013;Sörensson et al, 2013). Lønborg et al (2010a;2010b) published two articles on the same trial, followed up at 3 and 15 months, respectively …”

“…Patients treated with postconditioning were suggested to have improved on the New York Heart Association classification (Lønborg et al, 2010b). However, recent studies suggested that postconditioning could neither decrease infarct size (Sörensson et al, 2010;Freixa et al, 2012;Elżbieciak et al, 2013) nor increase LVEF in short-or long-term follow-up (Freixa et al, 2012;Elżbieciak et al, 2013). A multicenter, prospective, and randomized trial observed no improvement of myocardial reperfusion or short-term clinical outcomes in the postconditioning arm (Hahn et al, 2013).…”

Surrogate and clinical outcomes following ischemic postconditioning during primary percutaneous coronary intervention of ST‐Segment elevation myocardial infarction: A meta‐analysis of 15 randomized trials

“…A total of 15 randomized trials with 1,545 patients met our selection criteria . Of these, 785 underwent adjunctive IPoC and 760 underwent conventional primary PCI alone.…”

“…IPoC was effected by prolonged repeated inflations of a coronary balloon at low pressures following initial reperfusion. Although the protocol varied between the trials, IPoC involved four applications of 4–6 atmospheres pressure for 60 seconds separated by 60 s in 9 of the 15 studies . Direct stenting was utilized in all patients only in 3 studies , while the majority of studies did not use direct stenting at all.…”

“…Information on final infarct size was available for 9 studies, using delayed enhancement DE‐CMR in 6 studies and 99 mTc sesatimibi in the remainder (Table ). Weighted mean duration of follow‐up for infarct size assessment was 2 months (range hospital discharge to 6 months).…”