Effect of Post-Surgical Rai Therapy on Parathyroid Function in Patients with Differentiated Thyroid Cancer

Zhang, Aimi; Li, Panli; Liu, Qiufang; Peng, Shiyao; Huang, Gang; Song, Shaoli

doi:10.4158/ep-2019-0398

Cited by 5 publications

(2 citation statements)

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“…reported that PTH decreased in the short term but generally did not lead to hypocalcemia ( 6 ). However, some studies concluded that RAI did not affect the DTC patients’ parathyroid gland function ( 7 , 8 ). This may partially because their shortest research time point was one month post-RAI.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that parathyroid hormone and serum calcium levels may decrease at six months post-RAI ( 6 ). However, some studies suggested that RAI did not affect parathyroid function ( 7 , 8 ). Thus, the purpose of this study was to investigate PTH, serum calcium, phosphorus, and 25-OH-VD changes after RAI in patients with differentiated thyroid carcinoma (DTC) at different time points.…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid Changes After RAI in Patients With Differentiated Thyroid Carcinoma

et al. 2021

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ObjectiveThe purpose of this study was to investigate parathyroid hormone (PTH), serum calcium, phosphorus, and 25-hydroxyvitamin D (25-OH-VD) changes before and after radioactive iodine (RAI) in differentiated thyroid carcinoma (DTC) patients at different time points.MethodsA total of 259 DTC patients who received RAI were prospectively enrolled. We evaluated PTH, serum calcium, phosphorus, and 25-OH-VD levels at baseline pre-RAI, five days, six weeks, and six months post-RAI, respectively. We analyzed the risk factors of hypocalcemia at five days post-RAI.ResultsThe mean PTH, serum calcium and phosphorus values decreased five days post-RAI compared with pre-RAI (PTH 4.18 ± 1.23 pmol/L vs. 3.95 ± 1.41 pmol/L; calcium 2.27 ± 0.09 mmol/L vs. 2.20 ± 0.11 mmol/L; phosphorus 1.25 ± 0.17 vs. 0.98 ± 0.20 mmol/L, P < 0.05), and the differences were statistically significant. The mean 25-OH-VD levels did not significantly decrease at five days post-RAI. 21.2% (55/259) of patients had hypocalcemia at five days post-RAI, and all of them were given oral calcium supplements. At six weeks post-RAI, all of the above parameters were higher than those at five days post-RAI. Multivariate regression analysis showed that baseline pre-RAI serum calcium < 2.27 mmol/L, PTH < 4.18 pmol/L and negative 99mTcO4- thyroid imaging were risk factors for hypocalcemia at five days post-RAI.ConclusionFor DTC patients with normal PTH and serum calcium levels at pre-RAI, their PTH, serum calcium, and phosphorus levels decreased at five days post-RAI. About one-fifth of patients could have hypocalcemia at five days post-RAI. Lower baseline pre-RAI serum calcium and PTH levels and negative 99mTcO4- thyroid imaging were risk factors for hypocalcemia five days post-RAI.

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Section: Discussionmentioning

confidence: 99%