Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine

Wang, Hong Sheng; Ohkohchi, Nobuhiro; Enomoto, Yoshiharu; Usuda, Masahiro; Miyagi, Shigehito; Masuoka, Hiroo; Sekiguchi, Satoshi; Kawagishi, Naoki; Fujimori, Keisei; Sato, Akira; Satoh, Susumu

doi:10.1007/s00268-005-0294-4

Cited by 32 publications

(33 citation statements)

References 36 publications

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“…The reason may be that the total intrahepatic portal vasculature is decreased after major hepatectomy and intrahepatic portal vascular resistance increases as a result [33]. Portal hypertension after major hepatectomy has been reported previously as well [34][35][36]. A mild increase was observed after 12 h (P \ 0.05) of reperfusion, and this level persisted until the end of the current experiment.…”

Section: Discussionsupporting

confidence: 59%

“…The results support the previous evidence that pancreatitis after major hepatectomy is probably multifactorial. The portal congestion is involved in two ways: portal triad occlusion and postoperative portal hypertension, possibly caused by reduced intrahepatic portal vasculature [35] and the compromise of microcirculation [45]. However, pancreatitis occurs even if this effect is minimized by the construction of the portacaval shunt, probably as the result of release of ROS and inflammatory mediators from the liver and remote tissue damage from lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic injury after major hepatectomy: a study in a porcine model

et al. 2011

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Pancreatic injury after major hepatectomy: a study in a porcine model

et al. 2011

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“…After living donor liver transplantation a challenging task in recipients is to prevent a hyperacute rejection and small-for-size syndrome which is a dysfunction or failure of liver graft with portal hyperperfusion [40,41]. In living donors from which liver grafts were taken the morbidity and mortality rates were reported to be 29.1% and 0.23%, respectively [42].…”

Section: Discussionmentioning

confidence: 98%

Role of platelets on liver regeneration after 90% hepatectomy in mice

Myronovych

Murata

Chiba

et al. 2008

Journal of Hepatology

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102

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“…hepatectomy model (HM) was created following the animal model of liver regeneration described by Wang et al, 14 with some modifications of the anesthesia protocol. Briefly, three 8-week-old Landrace White pigs, weighing 25-35 kg, were employed.…”

Section: Animalsmentioning

confidence: 99%

Differentially expressed genes in a porcine adult hepatic stem-like cell line and their expression in developing and regenerating liver

Kano

Ishiyama

Iijima

et al. 2008

Laboratory Investigation

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To identify differentially expressed genes in adult hepatic stem cells, we performed suppression-subtractive hybridization (SSH) between adult porcine hepatic stem-like cells (HSLCs) and hepatocytes, and the expression of selected genes was assessed in porcine fetal livers and regenerating liver in an 80% hepatectomy model. SSH and subsequent differential screening selected 39 clones that were expressed differentially in HSLCs, including six known genes, 10 unknown genes, one unidentified gene and some chimeric fragments. Four of these genes showed significantly higher expression in HSLCs than in mature hepatocytes: anti-leukoproteinase, matrix Gla protein, amyloid-b precursor protein (APP) and dickkopf-3 (DKK-3). Among them, the mRNA expression of APP and DKK-3 was significantly higher in fifth GW fetal liver than in seventh and thirteenth GW fetal and adult livers, unlike the expression patterns of a-fetoprotein (AFP) or albumin. These mRNAs were detected in the parenchyma of fifth GW fetal liver, whereas in normal adult liver possible expression was limited to the periportal area. On the other hand, immunohistochemistry, Masson's trichrome staining and silver impregnation demonstrated APP and DKK-3 proteins in fifth GW fetal liver in which intralobular bile ducts and hepatic plates had not completely developed. DKK-3 and AFP mRNAs were upregulated on the seventh day (7D) after 80% hepatectomy. In the liver tissue, DKK-3 and AFP proteins were detected in mesenchymal cells in the periportal area and parenchyma, respectively. These data for DKK-3 expression in adult livers suggest the possible presence of adult HSLCs in the periportal area. The pattern of histological staining suggested that 7D liver was in the process of regeneration, showing a character similar to the fifth GW fetal liver. It is speculated that DKK-3 is upregulated in immature and developing livers, and has possible involvement in hepatic differentiation and liver regeneration.

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Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine

Abstract: These results indicate that, after extended hepatectomy, overload of portal flow is one of the most significant risk factors of hepatic failure by sinusoidal microcirculatory injury.

Cited by 32 publications

References 36 publications

Pancreatic injury after major hepatectomy: a study in a porcine model

Pancreatic injury after major hepatectomy: a study in a porcine model

Role of platelets on liver regeneration after 90% hepatectomy in mice

Differentially expressed genes in a porcine adult hepatic stem-like cell line and their expression in developing and regenerating liver

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