Effect of porcine placental extract on the mild menopausal symptoms of climacteric women

Kitanohara, Masataka; Yamamoto, Takeshi; Masunaga, Shin‐ichiro; Ohishi, Masami; Komatsu, Yasuhiko; Nagase, Mahiko

doi:10.1080/13697137.2017.1279140

Cited by 14 publications

(12 citation statements)

References 23 publications

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“…Placental extracts prepared from human or animal placenta have been used as ingredients in medicines, health foods, and cosmetics. Orally administered placental extracts have been reported to be effective for menopausal disorders [ 15 , 16 ] and their symptoms (e.g., knee pain, shoulder stiffness, and wrinkles below the eyes) [ 17 – 19 ]. Togashi et al reported that an orally administered human placental extract inhibits alcohol-induced hepatic disorder in a mouse model [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Nagata

Nagashimada

et al. 2018

Oncotarget

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Nonalcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver. NAFLD is associated with hepatic inflammation and oxidative stress, resulting in nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Placental extracts have been used to treat various chronic diseases due to their antioxidative effect. However, the effects of the extracts on the development of NASH have yet to be elucidated. Here, we demonstrated that supplementation with an oral porcine placental extract (PPE) attenuated lipid accumulation and peroxidation, insulin resistance, inflammatory and stress signaling, and fibrogenesis in the liver of NASH model mice fed a high-cholesterol and high-fat diet. The PPE reduced the number of M1-like liver macrophages, but increased the number of anti-inflammatory M2-like macrophages, resulting in a predominance of M2 over M1 macrophage populations in the liver of NASH mice. Accordingly, the PPE suppressed lipopolysaccharide-induced M1 polarization in isolated murine peritoneal macrophages, whereas it facilitated interleukin 4-induced M2 polarization. Furthermore, the PPE reduced the hepatic stellate cell (HSC) activation associated with the attenuated transforming growth factor-β/Smad3 signaling, both in the liver of NASH mice and in RI-T cells, a HSC line. The PPE may be a potential approach to prevent NASH by limiting lipid peroxidation, promoting M2 macrophage polarization, and attenuating HSC activation.

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Section: Introductionmentioning

confidence: 99%

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Nagata

Nagashimada

et al. 2018

Oncotarget

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“…Of these, 330 were excluded; 59 included fewer than 20 women per study arm and 54 were not an RCT; 126 did not clearly state a sample size calculation; 52 did not measure vasomotor symptoms as the primary outcome; 39 were secondary analysis. Following these exclusions, 214 RCT were included…”

Section: Resultsmentioning

confidence: 99%

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

Iliodromiti

Wang

Lumsden

et al. 2019

BJOG

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Background There is substantial variation in how menopausal vasomotor symptoms are reported and measured among intervention studies. This has prevented meaningful comparisons between treatments and limited data synthesis. Objectives To review systematically the outcome reporting and measures used to assess menopausal vasomotor symptoms from randomised controlled trials of treatments. Search strategy We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from inception to May 2018. Selection criteria Randomised controlled trials with a primary outcome of menopausal vasomotor symptoms in women and a sample size of at least 20 women per study arm. Data collection and analysis Data about study characteristics, primary vasomotor‐related outcomes and methods of measuring them. Main results The search identified 5591 studies, 214 of which were included. Forty‐nine different primary reported outcomes were identified for vasomotor symptoms and 16 different tools had been used to measure these outcomes. The most commonly reported outcomes were frequency (97/214), severity (116/214), and intensity (28/114) of vasomotor symptoms or a composite of these outcomes (68/214). There was little consistency in how the frequency and severity/intensity of vasomotor symptoms were defined. Conclusions There is substantial variation in how menopausal vasomotor symptoms have been reported and measured in treatment trials. Future studies should include standardised outcome measures which reflect the priorities of patients, clinicians, and researchers. This is most effectively achieved through the development of a Core Outcome Set. This systematic review is the first step towards development of a Core Outcome Set for menopausal vasomotor symptoms. Tweetable summary Menopausal hot flushes and night sweats have been reported in 49 different ways in clinical research. A core outcome set is urgently required.

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“…The mechanism of action of placental extracts in the wound healing is associated with the increase of TGF- β in the early phase of regeneration and VEGF in the late phase, as well as with the presence of FGF, amplification of angiogenesis, and the increase of expression of CD31 [ 28 , 60 ]. Application of placental extracts in menopausal disorders allowed reducing the number and severity of hot flushes, irritability, and normalize hormonal profile [ 54 , 61 ]; the amount of estrogen receptors in the experiment was increased, and the effects of vaginal atrophy were reduced, while the activity of osteoblasts was improved [ 53 ]. Experimental studies on the effect of placental extracts on behavior and physical condition in the animal model showed decrease in symptoms of fatigue and increased resistance to physical stress [ 53 , 62 ].…”

Section: Placental Extractsmentioning

confidence: 99%

Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects

Pogozhykh

Prokopіuk

Figueiredo

et al. 2018

Stem Cells International

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Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine.

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Effect of porcine placental extract on the mild menopausal symptoms of climacteric women

Abstract: Oral PPE at 300 mg/day improved the mild menopausal symptoms of climacteric women. Since oral PPE did not improve serum E2 and FSH levels, PPE is thought not to ameliorate hormonal balance itself but to improve subjective feelings of climacteric women.

Cited by 14 publications

References 23 publications

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects

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