Effect of pomegranate seed oil supplementation on the GLUT‐4 gene expression and glycemic control in obese people with type 2 diabetes: A randomized controlled clinical trial

Abstract

Abnormality in glucose transporter type 4 (GLUT-4) function and insulin secretion are the main causes of type 2 diabetes mellitus (T2DM). Due to adverse effects of antidiabetic drugs, nowadays, nutraceuticals have been of much interest to investigators. The aim of the present study was to determine the effect of pomegranate seed oil (PSO) on the GLUT-4 gene expression and glycemic control in obese people with T2DM. This randomized clinical trial was conducted on 52 obese type 2 diabetic patients for 8 weeks in Tabriz, Iran, in 2018. Patients were divided into the intervention group (n = 26; who consumed daily three capsules containing 1 g PSO) and the placebo group (n = 26; the same amounts paraffin). GLUT-4 gene expression and glycemic indices were evaluated by standard methods. GLUT-4 gene expression was increased significantly in the PSO group. Within-group changes in fasting blood sugar (FBS) and quantitative insulin sensitivity check index were significant in the PSO group. After adjusting the age, gender, and baseline values, FBS was significantly decreased. Insulin concentration, HbA1C, HOMA-IR, and HOMA-β did not manifest significant changes. PSO increased the GLUT-4 gene expression in diabetic patients without any side effects. However, future clinical studies are needed to confirm the obtained results.

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

“…An eight week supplementation with pomegranate peel extracts attenuated the systolic and diastolic blood pressure in patients with type 2 diabetes and also presented hypolipemic, hypoglycemic, and antioxidative potential [92]. Finally, clinical studies with pomegranate seed oil in type 2 diabetic patients have resulted in reductions in the levels of fasting blood sugar, interleukin-6 and TNF-α (tumor necrosis factor-α); however, no significant changes have been observed in insulin and lipid profiles [93,94].…”

Molecular mechanisms of anticancer effect of rutin

“…Thus, different herbs may possess the capability of inhibiting cancers and may be regarded as chemo‐preventive agents (Mohseni et al, 2016; Tanaka, Kohno, & Mori, 2001). Currently, researcher have become more interested in combating toxicity with the use of these herbs (Ahmed et al, 2019; Bakhshaiesh et al, 2015; Khajebishak et al, 2019; Nikbakht, Sharifi, Emami, & Khodaie, 2014; Sharifi et al, 2020).…”

The potential effects of pomegranate peel extract and bee venom in improving the diabetes induced damaging of spiral artery

“…The tunica media and adventitia of the spiral artery of bee venom-treated placenta possessed densely grouping infl ammatory cells. Although bee venom-treatment was found to improve diabetes via managing blood sugar, triglyceride and total cholesterol level [30], it possessed sign of cytotoxicity manifested by a detected sign of infl ammation.…”