Effect of polyunsaturated fatty acids of the α‐linolenic series on the development of rat testicles

Ayala, S; Brenner, Rodolfo R.; Dumm, César Gomez

doi:10.1007/bf02533328

Cited by 45 publications

(18 citation statements)

References 21 publications

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“…Possible reasons for the discrepancy between our results and those of Ayala et al (1977) are: (a), the rats used in our investigations would have had very low reserves of 18:2W6, since they were born to mothers fed 18:3w3 , and this may have resulted in a more rapid degeneration of the testes; (b), the duration of the spermatogenic cycle in the rat is 7-8 weeks (see Clermont, 1972) (Panos, Klein & Finerty, 1959). If the degeneration is primary any of the metabolites of 18:2w6 could be involved; but since 20:44w6 and 22: 5w6 are the acids found in the highest concentration (Table 3) it is most likely that one or both of these fatty acids could be responsible.…”

Section: Discussioncontrasting

confidence: 49%

“…Nicolaysen (1962) commented that rats fed cod liver oil, which is rich in derivatives of 18: 3w3, were sterile, but experimental details were scanty. Ayala, Brenner & Dumm (1977), however, reported normal testicular development in rats fed from weaning to 7-9 weeks of age on fish oil containing high concentrations of derivatives of 18:3w3. The results of our experiments show that when male rats were reared from weaning for 7-63 weeks on 18: 3w3 as the sole source of essential fatty acid, degeneration of the seminiferous tubules occurred and increased in severity with time.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

et al. 1983

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SUMMARYIn two experiments a total of twelve male rats were reared from weaning for up to 63 weeks on an essential fatty acid (EFA)-deficient diet alone (2 x two animals) or supplemented with the methyl esters of linoleic acid (18: 2w6) (2 x two animals) or linolenic acid (18: 3w3) (2 x two animals). Testicular development was normal in rats given 18:2w6, but in rats fed the EFAdeficient diet alone, and in those supplemented with 18:3w3 the testes were reduced in size. Histologically, a degeneration of the seminiferous tubules was noted, with progressive loss of the germinal cells, and with an absence of spermatozoa in the lumina of the seminiferous tubules and epididymides. Leydig cells appeared unaffected, and were prominent. The six rats in Experiment 1 were capable of mating with females reared on commercial diets, but only the two 18: 20)6 supplemented animals were fertile. There was a marked reduction in the percentage of arachidonic acid (20:4wj6) and docosapentaenoic acid (22: 516) in the total fatty acids of the atrophic testes. There was no compensatory increase in long-chain derivatives of 18: 3w3 in the 18: 3w3 fed rats and it is concluded that linolenic acid cannot replace linoleic acid in the development of the rat testis.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

et al. 1983

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“…This suggests that the testes or the epididymides have a very active FA metabolism that preferentially accumulates long-chain PUFAs, metabolizes PUFAs into long-chain metabolites more efficiently than other tissues, or both. In animal models, fish oil supplementation increases testicular concentrations of DHA (35,37,38). Further, the expression pattern of enzymes involved in PUFA metabolism in the testes suggests a very active FA metabolism.…”

Section: Discussionmentioning

confidence: 96%

Processed Meat Intake Is Unfavorably and Fish Intake Favorably Associated with Semen Quality Indicators among Men Attending a Fertility Clinic

Afeiche

Gaskins

Williams

et al. 2014

The Journal of Nutrition

105

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Emerging literature suggests that menÕs diets may affect spermatogenesis as reflected in semen quality indicators, but literature on the relation between meat intake and semen quality is limited. Our objective was to prospectively examine the relation between meat intake and indicators of semen quality. Men in subfertile couples presenting for evaluation at the Massachusetts General Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility. A total of 155 men completed a validated food-frequency questionnaire and subsequently provided 338 semen samples over an 18-mo period from 2007-2012. We used linear mixed regression models to examine the relation between meat intake and semen quality indicators (total sperm count, sperm concentration, progressive motility, morphology, and semen volume) while adjusting for potential confounders and accounting for within-person variability across repeat semen samples. Among the 155 men (median age: 36.1 y; 83% white, non-Hispanic), processed meat intake was inversely related to sperm morphology. Men in the highest quartile of processed meat intake had, on average, 1.7 percentage units (95% CI: 23.3, 20.04) fewer morphologically normal sperm than men in the lowest quartile of intake (P-trend = 0.02). Fish intake was related to higher sperm count and percentage of morphologically normal sperm. The adjusted mean total sperm count increased from 102 million (95% CI: 80, 131) in the lowest quartile to 168 million (95% CI: 136, 207) sperm in the highest quartile of fish intake (P-trend = 0.005). Similarly, the adjusted mean percentages of morphologically normal sperm for men in increasing quartiles of fish intake were 5.9 (95% CI: 5.0, 6.8), 5.3 (95% CI: 4.4, 6.3), 6.3 (95% CI: 5.2, 7.4), and 7.5 (95% CI: 6.5, 8.5) (P-trend = 0.01). Consuming fish may have a positive impact on sperm counts and morphology, particularly when consumed instead of processed red meats.

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“…In developing rats exposed to CTD, all fatty acids analysed were elevated when compared to control, but only docosapentaenoic acid, arachidonic acid, palmitic acid and palmitoleic acid reached to significant levels. Rat testes contain relatively substantial amounts of PUFAs mainly arachidonic acid (20:4 n6) and docosapentaenoic acid (22:5 n6), which are involved in spermatogenesis and androgenic activity of Leydig cells (Ayala et al 1977;Davis and Coniglio 1966). Our finding related to increased fatty acid is consistent with previous report that herbicide, atrazine, stimulates fatty acid synthesis (El-Sheekh et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

et al. 2012

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Clothianidin (CTD) is one of the latest members of the synthetic organic insecticides, the neonicotinoids. In the present study, it was aimed to investigate if daily oral administration of CTD at low doses for 90 days has any deleterious effects on reproductive functions of developing male rats. Animals were randomly divided into four groups of six rats each, assigned as control rats, or rats treated with 2 (CTD-2), 8 (CTD-8) or 32 (CTD-32) mg CTD/kg body weight by oral gavage. The significant decreases of the absolute weights of right cauda epididymis and seminal vesicles, and body weight were detected in the animals exposed to CTD administration at 32 mg/kgBW/day. Epididymal sperm concentration decreased significantly in CTD-32 group and the abnormal sperm rates increased in CTD-8 and CTD-32 groups when compared to control group. The testosterone level was significantly decreased in CTD-32 group when compared to control group. The administration of all CTD doses resulted in a significant decrease in the level of GSH. The number of TUNEL-positive cells significantly increased in the germinal epithelium of testis of rats exposed to CTD at 32 mg/kgBW/day. In groups CTD-8 and CTD-32, only docosapentaenoic, arachidonic, palmitic and palmitoleic acids were significantly elevated when compared to control. The ratios of 20:4/18:2 and 18:1n-9/18:0 were decreased when rats exposed to CTD. Sperm DNA fragmentation was observed in CTD-32 group, but not CTD-2 and CTD-8. It is concluded that low doses of CTD exposure during critical stages of sexual maturation had moderate detrimental effects on reproductive organ system and more severe effects are likely to be observed at higher dose levels. In addition, the reproductive system may be more sensitive to exposure of CTD even earlier in development (prenatal and early postnatal), and therefore it could be expected that more severe effects could also be observed at the NOAEL dose levels, if dosing had occurred in utero or early postnatal.

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Effect of polyunsaturated fatty acids of the α‐linolenic series on the development of rat testicles

Cited by 45 publications

References 21 publications

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

Processed Meat Intake Is Unfavorably and Fish Intake Favorably Associated with Semen Quality Indicators among Men Attending a Fertility Clinic

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

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